<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26490

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceARLPNFHIPAAVEVLTTGTYGRLPACIRERIVPPDPITAAEKRSTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVTFLVEQEFSVSLTVMSDGPTVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVIQSRLAESTNPLSEVYYILHYFCQSLQLEVLFSQTLRLIQDRLDDHIHVDEYVPGKCLSVSYWRELTNKDPRSELGYKLTIQVDQHDPARPLAVVHIPSLGSKESEIAHRAIRSDQLSMECLLVHTIYIRTRSRLSELKQELQTMLKDVECTLAGSPAILSVPILQPCLRAELLLVTVDTHTGMLQCHIPQYDAPLVPELTAALNGDHSRLPTLISELRFWITQRRCEKTLQHLAATPHERLPVLHHPDHPMSKISRHRMFVQLHRHPNVILIVAFKEKENSPCEIECSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDSGNNDQDGGCITEVVETTMSNKRRSTGIGGRTDAVGTSQNRRAKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLKLVQLPAPSPTIATSSAWHALLKRLLSVSIRVQGKGMAKTWMVEFVFFGSPLSSSHSKEQEKYNLRNMVSIKSYSYSKLVLAYGPNHAAIVTVQWNDKANFKLVFGRSPTNTVTNAHSIMKEQLEAHLNRHKNLAQIIHILNETLQPLTSISKLPTIPQLCVHARPRVPVQTFTIMPQCVTLVKIAYQGMYCLELRLRGGGLVSLRDGAYSHFDKSNVVDEFTPTQGLKAFLSKYVDENAVFRRRSQSEDDNPPSPVTMDSDGGGSNVGGFLGHHRSGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTTNISQASQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPSSQSMASPAASNWPGSPSVPRPSPARPGQSPGHVALHSPQASDHKTGSHMSRVLPPRSWAGAVPTLLTHEALESLCCASPHPSGLPGPDMSPLERFLGCVYMRRQLQRFIQTDDCVTGINSTEPGVVHFKVESLQCRVGLNPQYFQSLHIKVQPLPEYKDQWTLEELQIIEKFFDTRVAAPPYKHNTLSGFGRMLNIRFKVLKDFVQIMKLELVPGLVQQQQLKWSVQLCLRIPPSTGQIVPPGSEGVHVCRSKILFFLQLTRIGMSYPGETSFVLPFVYDVTTNVTQLAERRDLNISPAITAASMQLKRFADYGANQSECSLFPSVRDLLANFTLPSEPPVISQVVASPAGNQVPSTQQIQNAAMQMHSPMAGGQGPPQGPYGIQSMPPMSMMGGPPQ
Length1371
PositionTail
OrganismCamponotus floridanus (Florida carpenter ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Formicinae> Camponotus.
Aromaticity0.06
Grand average of hydropathy-0.248
Instability index63.77
Isoelectric point8.38
Molecular weight151476.82
Publications
PubMed=20798317

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26490
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     388.32|      70|      78|     889|     958|       1
---------------------------------------------------------------------------
  817-  869 (67.64/27.89)	...................NP...PSPVT.M...DSDGGGSNVGgfLGH.HR.SG..........PQSPAQQ...rEGLRfHP.PLT....PPSGSN......PH
  870-  914 (58.06/22.78)	.TPAS...............P.H.........TTN..............iSQ.AS.....qhqsfGSSPATS....FNLA.SP.PSL....PPNTPNML....PH
  915-  993 (124.95/58.48)	PSPGSGLVAN......SPLNPMHVPSPAG.LMPTSSPGPCSNVQ..VGH.SP.AG.sfmqtghidGSPFPSS....QSMA.SPaASN....WPGSPS.V....PR
  994- 1053 (66.32/27.19)	PSPA...............RP.......G.....QSPG...HVA..L.H.SP.QAsdhktgshmsRVLPPRS....WAGA.VP.TLL....THEALESLccasPH
 1297- 1370 (71.36/29.88)	PSV.RDLLANftlpsePPVISQVVASPAGnQVPSTQQIQNAAMQ..M.H.SPmAG..........GQGPPQGpygiQSM...P.PMSmmggPP............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.07|      24|     199|     516|     554|       2
---------------------------------------------------------------------------
  321-  349 (34.21/10.03)	PQYdapLVPELTA..ALNGDhsRLP..TLISEL
  517-  544 (36.86/36.03)	PAY...FIPELAHvvALCDE..RIPfvTLAQEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.96|      16|     199|    1077|    1095|       3
---------------------------------------------------------------------------
 1077- 1092 (28.49/23.39)	QLQRF.IQTDDCVTGIN
 1097- 1113 (23.47/ 9.38)	GVVHFkVESLQCRVGLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.24|      21|     504|      79|      99|       6
---------------------------------------------------------------------------
   79-   99 (37.68/23.54)	LVEQEFSVSLTVMSDGPTVPW
  586-  606 (35.56/21.81)	LLKRLLSVSIRVQGKGMAKTW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26490 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPVTMDSDGGGSNVGGFLGHHRSGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTTNISQASQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPSSQSMASPAASNWPGSPSVPRPSPARPGQSPGHVALHSPQASDHKTGSHMSRVLP
2) NQVPSTQQIQNAAMQMHSPMAGGQGPPQGPYGIQSMPPMSMMGGPPQ
807
1325
1027
1371










Molecular Recognition Features






MoRF SequenceStartStop




NANANA