<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26479

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMGDQFRKVEQYSPKSSPRGARSPVVSRQDSTGTLKTTISLGKNPSIVHSGPFYLMKEPPGESELTGATNLMGYYGLEHSYTKFSGKKPKEQLSSFLPNLPGIIDKPGHHDNSSLRSVIEKPPIGGKELLPLTSVQLAGFRLHPGPLPEQYRYVNQAPQRKHKNKHKKHKHKPGEVLSGQEVATTDVGGSDTHEKKHKKQKRHDEEKEARKKRKKEKKRKKQKHSPEHTGSLTPSQHSNS
Length239
PositionHead
OrganismCamponotus floridanus (Florida carpenter ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Formicinae> Camponotus.
Aromaticity0.05
Grand average of hydropathy-1.244
Instability index50.26
Isoelectric point10.02
Molecular weight26778.02
Publications
PubMed=20798317

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26479
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.48|      14|      19|     192|     205|       1
---------------------------------------------------------------------------
  161-  174 (26.93/ 9.35)	HKNKHKKHKHKPGE
  192-  205 (27.70/ 9.78)	HEKKHKKQKRHDEE
  214-  226 (23.85/ 7.66)	KEKKRKKQK.HSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.62|      25|      34|      88|     121|       2
---------------------------------------------------------------------------
   96-  121 (42.03/31.37)	LP....NLPGIIDKPGHHDNsSLRSVIEKP
  129-  157 (42.59/15.12)	LPltsvQLAGFRLHPGPLPE.QYRYVNQAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26479 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDQFRKVEQYSPKSSPRGARSPVVSRQDSTGTLKTTISLG
2) SFLPNLPGIIDKPGHHDNSSLRSVIEKPPIGGKELLPLTSVQLAGFRLHPGPLPEQYRYVNQAPQRKHKNKHKKHKHKPGEVLSGQEVATTDVGGSDTHEKKHKKQKRHDEEKEARKKRKKEKKRKKQKHSPEHTGSLTPSQHSNS
2
94
41
239










Molecular Recognition Features






MoRF SequenceStartStop




1) KHKKHKH
2) KKHKKQKRHDEEKEARKKRKKEKKRKKQKHSP
3) MGDQFRKVEQYSPKS
4) MGYYGLEHSY
5) PFYLMK
6) QYRYVNQA
164
194
1
71
51
149
170
225
15
80
56
156