<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26476

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMGILYEKRPLKRPRLGPPDVYPQEPKQKEDELSLTNVKHGFTTIPQLADEFGTARSSNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGSKPLVALAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQEYYHMGNHVANTSNNTLKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLAYLCCRKLAHMCNNIESNNNPQSPSIIKNEVNKDANVAVQAPLNPLTIAFNDYLTCAHHRDIIYSLSTIIQVITLECSTALVWNSVGEGKAPSVLNGSPLDYLPCPPAALPCPPASSSNPTMKQLRIAQENIRARSQAAEGRWSCDKWQQSSAGTTTTKVLAALDALDRHSFDRMDASNSLDTLYAKIFTSSLKDSCNERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSTCSNGSPPVLPIFQSLLMKFLDMDAPVLDNTSSQSKTQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVSDHGRTMDYDDSKIDDDLDKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRVRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAVTMKFQNLSYFDQHVVTWQCATQVIEMLNLFSTSPFYYLPVHEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEVQLTTRSSQLVRSYTTNLSLYVVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSTCSLLKTKSHGVEAFSNAYPKIRAALYSTLQPTPSSHVYNSQFMVDVFTSPRRGGKIEAQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSNSSAFYIDVLNQVDVQDLSIHNSLAIFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDIDIEAEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNTRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATATKQPPKKVDIPLSHSSKGGGPASVGVGVGVSSSGPSELSISHILGTSDILGGGDDLGLDLAMSSSSSSAGMTTENVKGFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDNMLIPRQAQKLLHMICYPETPIEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFAPGCNDLSQWLDTVAKAAIDVFQLNNTLSSKPDKRSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTAGRERGRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKHIGSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSPSIRFVRQLLPLPKLAMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAVRLERKPLTYQNAHKLLRYHTHSQIRQASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSVGNVGVGNASTNGKGKAMKTKRNSRRVKGAATPTTPISQQMQQPPSQLQQMAFANQQAPVTQQPGMFTGQPPQPQQQWYGNQQTHTPAQQYGYGQQLPPAPVGGPRYERPGMNNQSKQALSNMLRLRLPSTQFMGSQQQPPNATPVAGPGAFQGMQRQQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQGIYAGIQQGMNQNYAGYGGQQMIQQQQQQQQQQTPQQTQQQQQQQLLQQQQQQQQQGILNQQQNMMFNQQQQMMAPQRGQEYMPQQRMQPGTARPPYLQAPNVTMNTMGPMGGGVQNQPAPPYRQSAGKPGAVGVTGVGTTNVSLQQNQQFQQQQAINQQRIRQQMLAMQQQQAQQQQQQAAQQQQQQQGGAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
Length2190
PositionKinase
OrganismCamponotus floridanus (Florida carpenter ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Formicinae> Camponotus.
Aromaticity0.07
Grand average of hydropathy-0.474
Instability index53.46
Isoelectric point7.63
Molecular weight244056.35
Publications
PubMed=20798317

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26476
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     304.27|      29|      29|    1827|    1855|       1
---------------------------------------------------------------------------
 1827- 1855 (62.08/27.81)	NQQA.P.VTQQP...........GMFTGQP.....P.............Q..........PQQQWYGNQQ
 1875- 1910 (26.46/ 7.21)	..GG.P.RYERP...........GM.NNQS.....K.............QalsnmlrlrlPSTQFMGSQQ
 1912- 1936 (33.56/11.32)	PPNAtP.VA.GP...........GAFQG................................MQRQQFIRQQ
 1940- 1963 (32.12/10.48)	QHGA.PgINPQQ...........GMFAAQQ.....Q.............Q..........QQQQ......
 1990- 2017 (43.87/17.27)	QQQQ.Q.QQQQQ...........TPQQTQ......Q.............Q..........QQQQLLQQQQ
 2020- 2052 (41.39/15.84)	QQQG.I.LNQQQ...........NMMFNQQqqmmaP.............Q..........RGQE.YMPQQ
 2058- 2097 (30.59/ 9.60)	TARP.P.YLQAPnvtmntmgpmgGGVQNQP.....A.............P..........PYRQSAGKPG
 2149- 2186 (34.19/11.68)	QQQ.....QQQQ...........GGAGGQQ.....PtpqlvthlqrhlsQ..........PPQHSYQHQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.03|      45|     176|     884|    1008|       2
---------------------------------------------------------------------------
  944- 1008 (65.67/176.35)	TCSLLKTKSHGVEAfsnaypkIRAALYS.TLQPTPsshvynsqfmvdvFTSPR.RGGKIEAQWARQL
 1140- 1186 (77.36/29.25)	TCHLLLRLFKTVEC.......PQPALYSvSTSPHP.............LPSGNtRGYSIKLSCDRHL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      62.15|      11|      23|    2112|    2122|       3
---------------------------------------------------------------------------
 1971- 1981 (19.78/ 6.16)	GIQQGMNQNYA
 2112- 2122 (22.22/ 7.85)	QQNQQFQQQQA
 2138- 2147 (20.16/ 6.43)	QQAQQ.QQQQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.78|      33|     190|     277|     309|       4
---------------------------------------------------------------------------
  277-  309 (59.95/39.77)	SELLARRLAYLCCRKLAHMCNNIESNN..NPQSPS
  462-  496 (51.83/33.28)	SNSLDTLYAKIFTSSLKDSCNERDTKTeyNPQQDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.61|      30|      30|    1233|    1262|       5
---------------------------------------------------------------------------
 1233- 1262 (52.09/28.74)	GGPASVGVGVGVSSSGPSE.LSISHILGTSD
 1265- 1295 (47.51/25.61)	GGGDDLGLDLAMSSSSSSAgMTTENVKGFSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.02|      24|      27|    1540|    1566|       7
---------------------------------------------------------------------------
 1542- 1566 (37.54/35.50)	GVFDtIQRNT...TATTDWAILLVQ..LVS
 1568- 1596 (30.48/15.54)	GVID.LNNNAelfTTVIDMLATLIHstLVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.91|      59|     532|      38|     109|       9
---------------------------------------------------------------------------
   38-  109 (84.29/83.40)	KHGFTTIPQLadeFGTARSSNVTAAkvGAYFNAILAK....KEELATMPDTGRKRQQINPKDNFwpvtartkNGIE
  579-  641 (99.62/64.18)	KTQFTNLVHL...FSELIRHDVFSH..DAYMCTLISRgdliQGPVASKPGTPSNREPIDEDSLF........PGID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.35|      27|      27|    1401|    1427|      10
---------------------------------------------------------------------------
 1396- 1425 (39.78/23.37)	QWldtVAKAAIDVFQLNNTLSSK.PDK.RSGS
 1426- 1443 (17.99/ 6.14)	IW..lVA...........PLVSKlPSA.VQGR
 1444- 1472 (32.57/17.67)	VL..kVAGQVLESGNWSKTAGRE.RGRsKSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.87|      16|      37|    1297|    1312|      11
---------------------------------------------------------------------------
 1297- 1312 (29.43/17.46)	AHHVLRQICSQEWVLE
 1337- 1352 (28.44/16.60)	AQKLLHMICYPETPIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.07|      18|      37|     783|     803|      16
---------------------------------------------------------------------------
  783-  803 (26.65/29.47)	SRSEFNFEAVTmkfQNLSY.FD
  823-  841 (30.42/21.74)	STSPFYYLPVH...EHVAFlFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.42|      14|     532|    1219|    1232|      19
---------------------------------------------------------------------------
 1219- 1232 (26.40/14.96)	PKKVDIPLSHSSKG
 1754- 1767 (28.02/16.35)	PGKADTPMSIDSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.81|      14|      19|    1014|    1027|      21
---------------------------------------------------------------------------
 1014- 1027 (25.81/17.98)	NRYSFVCNAIVAVC
 1036- 1049 (26.00/18.17)	NDIAITCAELTACC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.78|      10|      19|    1068|    1077|      24
---------------------------------------------------------------------------
 1068- 1077 (17.40/12.14)	NSSAFYIDVL
 1089- 1098 (16.39/10.97)	NSLAIFTSIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26476 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPS
2) GILNQQQNMMFNQQQQMMAPQRGQEYMPQQRMQPGTARPPYLQAPNVTMNTMGPMGGGVQNQPAPPYRQSAGKPGAVGVTGVGTTNVSLQQNQQFQQQQAINQQRIRQQMLAMQQQQAQQQQQQAAQQQQQQQGGAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
3) QIRQASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSVGNVGVGNASTNGKGKAMKTKRNSRRVKGAATPTTPISQQMQQPPSQLQQMAFANQQAPVTQQPGMFTGQPPQPQQQWYGNQQTHTPAQQYGYGQQLPPAPVGGPRYERPGMNNQSKQALSNMLRLRLPSTQFMGSQQQPPNATPVAGPGAFQGMQRQQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQ
4) YAGYGGQQMIQQQQQQQQQQTPQQTQQQQQQQLLQQQQQQQQ
668
2023
1727
1980
708
2190
1961
2021










Molecular Recognition Features






MoRF SequenceStartStop




1) MGILYEKRPLKRPRLGPPDVY
2) NMLRLRL
3) QPTPQLVTHLQRHL
1
1894
2162
21
1900
2175