<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26470

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGEQQALSSLQLVAFRDVLDNVVQQAHAELQQLAERLPAVGDEERKRQLLQHLQTTRQRLQRLHVCAQWAHKAKAVNTCREVLKASQDHGAAFVHAADELFRLNEELRFCRAPLFDVSFALHIMQTGTYRLLPSVIEDELQQPGQRLERPGEVDEARRGQQRRDALRRLDFLLRSKLLASELPAGMRVLRVRGGQAWVAGGGGQYKAQLTLVPAPRDDVTLAKYRPPGEAEEAEGKHQRQWLQQHIEQRMWVAGDVEQLARLGKTGWVVVPQPASASKEQQQGKASSAPAPSSSLALSQQPAATADSKEQLPLVRDELDQQQQQGEAGQQLPPFSISPLAAMHAILCQTAGRLALFSILLSDARQLEGGSWKGCLKLSRAASGSGIRLAYWQQLPVVGYSELLCLREGQPYQLEAGGTQQQQQEAPAVEVSLQEDGRLAAASSPQLQHPQSGEHIQLPLPLDSAASLSADRLLLQAAASSAAVQLAAVQAVLQRAGRLAPAGNHAELLLLGAASPAAGTAGVAAQAPPPTSPLLQLWSGGSLQLSLTVQLRSGRLLLAAGSALLESEQGPSAAAAVAAAQQQLDAAQREALTQPLPPGSSRGMLGAALAAEALGRLSLQLSMRQRMDAAAADASACGLRRATLPARLLQQHLRQVALLVEPPTPNTLTLALPAFLPPPDMQQWARQQQQQPGSGGAGAAGIDGGATRCFLLIDFGEAAAAGGTNGNAERRGAPPRLLLAVCSCTGRGTVTRVLQLSELPQELLLQAQQAAEGAGGALAGNAPASRKRRADDAAADGEGEQPAPAPATRGGGGGRLGLASLSSWCRRQASWAALRAQMLLLPVQYAEELALAPAAQQQPAQAQQLQPPPQQQQVIRLPKAPVLGELESWAAAHLAAQHGGSNARAPPPARRPVATMQLEAGEAEAGAGRWRVDIASAYFGHLEQLLRRQGIALAPPQPDAAHIAAHSGGLTMHYSLQKGKRERTFEQRRRQQQQQRSSAGIDGACRHSVLTGVTDMVRVGMLHLCLTRLAGCMAVNPLAAAAQALAAAAAAGPPPAGAAAAGGANGGLAAPGGGVGLLGSMDFLASGGMDLLAGAKEPGNGGLPNGVAAPGGQGPAGPASGGEAAEGLVWPLPGCGSVRLQAAGLTHVELLVAPPPAPKGQLGAAAQPPPPPVRVTVTWADTLAGAPRAAGGGGGGLMQHIRCGVACEPPLPPPVTAALAQQLEAGRADLFLDALCLAAHSAAAAAAQLTPQAQRAAGLLPGAVKLLGAGGEATSSVEGAAGGAHSSALRLRAQVQHGEHAATLCLSFHAVGYTLLQLQPAQTHAANAAAASWMPAMWQRLSQRVPSFAPLDAGGLAPTAADGGGSSAQQAAAGEAPQKRLVRQAWVHRDGLAAVLAEILHAVGAPAAAAPADGTALA
Length1418
PositionTail
OrganismChlorella variabilis (Green alga)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Trebouxiophyceae> Chlorellales> Chlorellaceae> Chlorella clade> Chlorella.
Aromaticity0.03
Grand average of hydropathy-0.122
Instability index57.65
Isoelectric point8.64
Molecular weight146454.72
Publications
PubMed=20852019

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26470
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     404.35|      55|      55|     830|     884|       1
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  339-  386 (40.00/ 7.04)	PLAAMHAIL......CQ.TAGRL..ALFSILL...SDARQLEGGS.WKGC..LKLSRA.ASgS....G
  387-  437 (39.70/ 6.91)	IRLAYWQQ....LPvVG.YSELL..CL...REGQP...YQLEAGGTQQQQ..QEAPAV.EV.SlqedG
  508-  544 (40.65/ 7.32)	........LL.LLG...........AASPAAGTAGVAAQ..APPP.TSPL..LQLWSG.GS.L....Q
  653-  695 (45.22/ 9.29)	....LRQVAL.LVE.PP.TPNTL..TLALPAFLPPPDMQQWARQQQQQ...........PG.S....G
  830-  884 (99.40/32.66)	SWAALRAQML.LLP.VQ.YAEEL..ALAPAAQQQPAQAQQLQPPPQQQQV..IRLPKA.PV.L....G
  888-  940 (50.62/11.62)	SWAA..AH....LA.AQ.HGGSN..ARAPPPARRPVATMQLEAGEAEAGAgrWRVDIA.SAyF....G
 1217- 1268 (44.42/ 8.95)	..AALAQQ....LE.AG.RADLFldALCLAAHSAAAAAAQLTPQAQRAAG..L.LPGAvKL.L....G
 1307- 1354 (44.33/ 8.91)	SFHAVGYTLLqLQP.AQtHA.....ANAAAASWMPAMWQRL.....SQRV..PSF..A.PLdA....G
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     416.77|      69|     116|    1026|    1098|       2
---------------------------------------------------------------------------
  573-  646 (51.98/17.05)	.AA.AAVAAAqqqldaaqrEALTQPLPP....GSSR....GmlGAAL...AAEAlgrlSLQLSMRQRmdAAAADASACGLRRATLP...........A
  698-  736 (63.57/16.62)	GAA....GID.........GGATR...............CF.....LLIDFGEA...............AAAGGTNGNAERRGAPP...........R
  737-  790 (70.82/19.48)	LLL.A.................VCSCTGRGTVTRVLQLSEL..PQELLLQAQQ.....AAEGAGGAL..A......GNAPASRKRR...........A
 1057- 1116 (97.88/30.17)	GAA.AAGGAN.........GGLAAPGGGVGLLGSMDFLASG..GMDLLAGAKEP...gNG.....GL.......PNGVAAPGGQGP...........A
 1117- 1184 (81.69/23.77)	GPA.SGGEAA.........EGLVWPLPGC...GSVRLQAAGltHVELLV...AP...........PP..APKGQ.LGAAAQPPPPPvrvtvtwadtlA
 1185- 1214 (50.82/11.58)	GAPrAAGG..................GGGGL...MQHIRCG........VACEP...........PL................PPP............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.91|      15|      40|     279|     294|       3
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  279-  293 (25.46/ 6.27)	KEQQQGKASSAPAPS
  321-  335 (26.31/ 6.88)	QQQQQGEAGQQLPPF
  448-  462 (24.14/ 8.96)	QHPQSGEHIQLPLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     324.38|      97|     101|      61|     161|       4
---------------------------------------------------------------------------
    7-   49 (25.82/ 6.92)	............................................................ALSSLQLVAFRdVLDNVVQQahaE.......LQQL.AERLPAVG..DE.ERKRQ
   61-  161 (161.21/106.46)	LQRLHVCAQWAHKAKAVNTCREVLKASQdhGAAFVHAADELFRlnEELRFCRAPLFDVSFALHIMQTGTYR.LLPSVIED...E.......LQQP.GQRLERPGEVDE.ARRGQ
  167-  265 (137.35/79.78)	LRRLDFLLRSKLLASELPAGMRVLRVRG..GQAWVAGGGGQYK..AQLTLVPAPRDDVTLA.......KYR.PPGEAEEA...EgkhqrqwLQQHiEQRMWVAGDVEQlARLGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.96|      15|      81|     468|     482|       5
---------------------------------------------------------------------------
  468-  482 (26.09/10.30)	LSADRLLLQAAASSA
  486-  500 (20.33/ 6.30)	LAAVQAVLQRAGRLA
  551-  563 (21.54/ 7.14)	LRSGRLLL..AAGSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.37|      30|      40|     942|     971|       7
---------------------------------------------------------------------------
  942-  967 (41.54/19.65)	.................LEQLLRRQG.IALAPPQPDAAHI...AAHS
  968- 1008 (29.86/11.60)	GGLTmhyslqkgkrertFEQR.RRQ.....QQQQRSSAGIdgaCRHS
 1011- 1047 (24.97/ 8.22)	TGVT....dmvrvgmlhL.CLTRLAGcMAVNPLAAAAQAL...AA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.71|      36|      89|    1269|    1304|      10
---------------------------------------------------------------------------
 1269- 1304 (60.50/31.26)	AGGEATSSVEGAAGGAHSSALRLRAQVQHGEHAATL
 1361- 1396 (62.21/32.41)	ADGGGSSAQQAAAGEAPQKRLVRQAWVHRDGLAAVL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26470 with Med14 domain of Kingdom Viridiplantae
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