<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26470
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MAGEQQALSSLQLVAFRDVLDNVVQQAHAELQQLAERLPAVGDEERKRQLLQHLQTTRQRLQRLHVCAQWAHKAKAVNTCREVLKASQDHGAAFVHAADELFRLNEELRFCRAPLFDVSFALHIMQTGTYRLLPSVIEDELQQPGQRLERPGEVDEARRGQQRRDALRRLDFLLRSKLLASELPAGMRVLRVRGGQAWVAGGGGQYKAQLTLVPAPRDDVTLAKYRPPGEAEEAEGKHQRQWLQQHIEQRMWVAGDVEQLARLGKTGWVVVPQPASASKEQQQGKASSAPAPSSSLALSQQPAATADSKEQLPLVRDELDQQQQQGEAGQQLPPFSISPLAAMHAILCQTAGRLALFSILLSDARQLEGGSWKGCLKLSRAASGSGIRLAYWQQLPVVGYSELLCLREGQPYQLEAGGTQQQQQEAPAVEVSLQEDGRLAAASSPQLQHPQSGEHIQLPLPLDSAASLSADRLLLQAAASSAAVQLAAVQAVLQRAGRLAPAGNHAELLLLGAASPAAGTAGVAAQAPPPTSPLLQLWSGGSLQLSLTVQLRSGRLLLAAGSALLESEQGPSAAAAVAAAQQQLDAAQREALTQPLPPGSSRGMLGAALAAEALGRLSLQLSMRQRMDAAAADASACGLRRATLPARLLQQHLRQVALLVEPPTPNTLTLALPAFLPPPDMQQWARQQQQQPGSGGAGAAGIDGGATRCFLLIDFGEAAAAGGTNGNAERRGAPPRLLLAVCSCTGRGTVTRVLQLSELPQELLLQAQQAAEGAGGALAGNAPASRKRRADDAAADGEGEQPAPAPATRGGGGGRLGLASLSSWCRRQASWAALRAQMLLLPVQYAEELALAPAAQQQPAQAQQLQPPPQQQQVIRLPKAPVLGELESWAAAHLAAQHGGSNARAPPPARRPVATMQLEAGEAEAGAGRWRVDIASAYFGHLEQLLRRQGIALAPPQPDAAHIAAHSGGLTMHYSLQKGKRERTFEQRRRQQQQQRSSAGIDGACRHSVLTGVTDMVRVGMLHLCLTRLAGCMAVNPLAAAAQALAAAAAAGPPPAGAAAAGGANGGLAAPGGGVGLLGSMDFLASGGMDLLAGAKEPGNGGLPNGVAAPGGQGPAGPASGGEAAEGLVWPLPGCGSVRLQAAGLTHVELLVAPPPAPKGQLGAAAQPPPPPVRVTVTWADTLAGAPRAAGGGGGGLMQHIRCGVACEPPLPPPVTAALAQQLEAGRADLFLDALCLAAHSAAAAAAQLTPQAQRAAGLLPGAVKLLGAGGEATSSVEGAAGGAHSSALRLRAQVQHGEHAATLCLSFHAVGYTLLQLQPAQTHAANAAAASWMPAMWQRLSQRVPSFAPLDAGGLAPTAADGGGSSAQQAAAGEAPQKRLVRQAWVHRDGLAAVLAEILHAVGAPAAAAPADGTALA |
Length | 1418 |
Position | Tail |
Organism | Chlorella variabilis (Green alga) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Trebouxiophyceae>
Chlorellales> Chlorellaceae> Chlorella clade> Chlorella.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.122 |
Instability index | 57.65 |
Isoelectric point | 8.64 |
Molecular weight | 146454.72 |
Publications | PubMed=20852019
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Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
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GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26470
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
8| 404.35| 55| 55| 830| 884| 1
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339- 386 (40.00/ 7.04) PLAAMHAIL......CQ.TAGRL..ALFSILL...SDARQLEGGS.WKGC..LKLSRA.ASgS....G
387- 437 (39.70/ 6.91) IRLAYWQQ....LPvVG.YSELL..CL...REGQP...YQLEAGGTQQQQ..QEAPAV.EV.SlqedG
508- 544 (40.65/ 7.32) ........LL.LLG...........AASPAAGTAGVAAQ..APPP.TSPL..LQLWSG.GS.L....Q
653- 695 (45.22/ 9.29) ....LRQVAL.LVE.PP.TPNTL..TLALPAFLPPPDMQQWARQQQQQ...........PG.S....G
830- 884 (99.40/32.66) SWAALRAQML.LLP.VQ.YAEEL..ALAPAAQQQPAQAQQLQPPPQQQQV..IRLPKA.PV.L....G
888- 940 (50.62/11.62) SWAA..AH....LA.AQ.HGGSN..ARAPPPARRPVATMQLEAGEAEAGAgrWRVDIA.SAyF....G
1217- 1268 (44.42/ 8.95) ..AALAQQ....LE.AG.RADLFldALCLAAHSAAAAAAQLTPQAQRAAG..L.LPGAvKL.L....G
1307- 1354 (44.33/ 8.91) SFHAVGYTLLqLQP.AQtHA.....ANAAAASWMPAMWQRL.....SQRV..PSF..A.PLdA....G
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 416.77| 69| 116| 1026| 1098| 2
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573- 646 (51.98/17.05) .AA.AAVAAAqqqldaaqrEALTQPLPP....GSSR....GmlGAAL...AAEAlgrlSLQLSMRQRmdAAAADASACGLRRATLP...........A
698- 736 (63.57/16.62) GAA....GID.........GGATR...............CF.....LLIDFGEA...............AAAGGTNGNAERRGAPP...........R
737- 790 (70.82/19.48) LLL.A.................VCSCTGRGTVTRVLQLSEL..PQELLLQAQQ.....AAEGAGGAL..A......GNAPASRKRR...........A
1057- 1116 (97.88/30.17) GAA.AAGGAN.........GGLAAPGGGVGLLGSMDFLASG..GMDLLAGAKEP...gNG.....GL.......PNGVAAPGGQGP...........A
1117- 1184 (81.69/23.77) GPA.SGGEAA.........EGLVWPLPGC...GSVRLQAAGltHVELLV...AP...........PP..APKGQ.LGAAAQPPPPPvrvtvtwadtlA
1185- 1214 (50.82/11.58) GAPrAAGG..................GGGGL...MQHIRCG........VACEP...........PL................PPP............
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 75.91| 15| 40| 279| 294| 3
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279- 293 (25.46/ 6.27) KEQQQGKASSAPAPS
321- 335 (26.31/ 6.88) QQQQQGEAGQQLPPF
448- 462 (24.14/ 8.96) QHPQSGEHIQLPLPL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 324.38| 97| 101| 61| 161| 4
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7- 49 (25.82/ 6.92) ............................................................ALSSLQLVAFRdVLDNVVQQahaE.......LQQL.AERLPAVG..DE.ERKRQ
61- 161 (161.21/106.46) LQRLHVCAQWAHKAKAVNTCREVLKASQdhGAAFVHAADELFRlnEELRFCRAPLFDVSFALHIMQTGTYR.LLPSVIED...E.......LQQP.GQRLERPGEVDE.ARRGQ
167- 265 (137.35/79.78) LRRLDFLLRSKLLASELPAGMRVLRVRG..GQAWVAGGGGQYK..AQLTLVPAPRDDVTLA.......KYR.PPGEAEEA...EgkhqrqwLQQHiEQRMWVAGDVEQlARLGK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 67.96| 15| 81| 468| 482| 5
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468- 482 (26.09/10.30) LSADRLLLQAAASSA
486- 500 (20.33/ 6.30) LAAVQAVLQRAGRLA
551- 563 (21.54/ 7.14) LRSGRLLL..AAGSA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 96.37| 30| 40| 942| 971| 7
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942- 967 (41.54/19.65) .................LEQLLRRQG.IALAPPQPDAAHI...AAHS
968- 1008 (29.86/11.60) GGLTmhyslqkgkrertFEQR.RRQ.....QQQQRSSAGIdgaCRHS
1011- 1047 (24.97/ 8.22) TGVT....dmvrvgmlhL.CLTRLAGcMAVNPLAAAAQAL...AA..
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 122.71| 36| 89| 1269| 1304| 10
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1269- 1304 (60.50/31.26) AGGEATSSVEGAAGGAHSSALRLRAQVQHGEHAATL
1361- 1396 (62.21/32.41) ADGGGSSAQQAAAGEAPQKRLVRQAWVHRDGLAAVL
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