<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26462

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAVPGGAEEAEKLNKMSTLLERLHAKYNQNRPWTETMKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVILHESNVPRSLGMNVSVTIEGTMAMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQGCTGIPLFDTAPTFVPLYELITQFELSKEADPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPIILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSAIGSSPTPPHHTPPPLSSPAGNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGSKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPATNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFAEEYFDESSQSGDTDDFKGYASQALSTLGVQVLGGDGGDNKFKGSNPSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSNMAGSGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGPSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSMKPESWSKSPISADQSLSMASSAILSAERPSRPSPEFLIGEEDDDLMDVALIGN
Length1583
PositionMiddle
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.04
Grand average of hydropathy-0.637
Instability index54.54
Isoelectric point8.88
Molecular weight167988.99
Publications
PubMed=15592404

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	ISS:UniProtKB
nucleolus	GO:0005730	ISS:UniProtKB
nucleoplasm	GO:0005654	IEA:Ensembl
nucleus	GO:0005634	ISS:UniProtKB

GO - Biological Function
chromatin binding	GO:0003682	ISS:UniProtKB
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	ISS:UniProtKB
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IBA:GO_Central
thyroid hormone receptor binding	GO:0046966	ISS:UniProtKB
transcription coactivator activity	GO:0003713	ISS:UniProtKB
transcription coregulator activity	GO:0003712	ISS:UniProtKB
transcription corepressor activity	GO:0003714	ISS:UniProtKB
vitamin D receptor binding	GO:0042809	IBA:GO_Central

GO - Biological Process
androgen biosynthetic process	GO:0006702	ISS:UniProtKB
angiogenesis	GO:0001525	ISS:UniProtKB
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	ISS:UniProtKB
cellular response to epidermal growth factor stimulus	GO:0071364	ISS:UniProtKB
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IBA:GO_Central
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
erythrocyte development	GO:0048821	ISS:UniProtKB
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	ISS:UniProtKB
keratinocyte differentiation	GO:0030216	ISS:UniProtKB
lens development in camera-type eye	GO:0002088	ISS:UniProtKB
liver development	GO:0001889	IEA:Ensembl
megakaryocyte development	GO:0035855	ISS:UniProtKB
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	ISS:UniProtKB
negative regulation of apoptotic process	GO:0043066	ISS:UniProtKB
negative regulation of keratinocyte proliferation	GO:0010839	ISS:UniProtKB
negative regulation of neuron differentiation	GO:0045665	ISS:UniProtKB
negative regulation of transcription by RNA polymerase II	GO:0000122	ISS:UniProtKB
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	ISS:UniProtKB
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	ISS:UniProtKB
positive regulation of transcription by RNA polymerase II	GO:0045944	ISS:UniProtKB
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISS:UniProtKB
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of RNA biosynthetic process	GO:2001141	ISS:UniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	ISS:UniProtKB
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26462
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1148.12|     182|     182|     937|    1118|       1
---------------------------------------------------------------------------
  560-  743 (198.92/51.75)	GTTTP.....TNTFPGGPITTLFNMS.....................ISMKERHDSvgHGEDfSKVSQNPIL......TSLLQITG................nvGSAIGS..SPTPPHHTPPplSS..PAGNTKnhpmlmN.LLKENPPQDF...STL..Y.GSS....P.LERQNSSSGSP.....R..ME.M.............GPGGSKQ...KKKKSRMPAD...........KPKHQteddfqrelfsmdvdSQNPI.FDVNMT..ADTLDTPHI........T.P.AP.S
  744-  860 (148.33/36.62)	QCSTPP............TTYPQPIPH..SQPSIQ........RMVRLSS......................................................SDSIGAdvTDIL.................S......D.IAEEAS.......K................LPATNEDCPPiGTPVR..DS.S.............SSGHSQSAL.......FDPD...........VFQTN...............NSENP.YTDPADliADAAVSPNSD.....SSN.HfFP.D
  861- 1051 (263.03/70.93)	GVDFNP.DLLNSQSQSGF........A..EEY..............FDESSQSGDT..DDFK.GYASQALSTlgvqvlGGDGGDNKfkgsnpsdtvdfsiiaaaSKALGS..SDIMEHHSGG..QS..PLLNTG......D.LGKEKSQKRV...KEG..N.GSG....S.NMAGSGIDGKP.GKRSR..TP.S.............SDGKSKEKLPKRKKQETDGK...........SPSHS...............SSNRP.FTPPAS..TGGSKSPGSS.....GRS.Q.TP.P
 1052- 1213 (218.16/57.51)	GVATPPIPKITIQIPKGTVTVGKPSSH..GQYTSS........GSVTSSSSKSHHS..HSSS.SSSSSSSST......SGKIKSSK..............segsSGSKMS..SSLYSSQ.GG..SSsgPSKSSA......QsVGKPGSSPIT...KHGlsS.GSG....StKMKP...QGKP....SSlmNP.S................MSKPNIS......................PSHS..................RP.........SGGSDKLASP.....MK.....PvP
 1214- 1352 (143.47/35.16)	G..TPPSSK.....AKSPISSGSGGSHmsGTGSSSsmksssgmGSSGSMSQKPPPS..SNSS.TASSSSFSS......SG...SS............................................................................mSSS....Q.NQHGSS.KGKS.PSRNK..KP.SltavidklkhgvvTSGPGGDD.P......MDGQ..........mGPSSN...............SSSH..........TMSSKHNMSG.....GEF.Q.....
 1353- 1480 (120.11/28.18)	.....................GKR..........................EKSDKE..KSKV.SVSGGSVDS......SKKTSDSK......nvgstgvakiiiSK............HDGG...S..PSI.............KAK....VtlqKPG..E.GGGdslrP.QMASSKSYGSP.LISGS..TP.........................KHER.....C...........SPSHS...............KS..PaYTPQNI..DSESES.GSS...iaEKSyQ.NS.P
 1485- 1559 (56.10/ 9.03)	GI..RPLPE.......................................................................................................................................................................................yS.............SEKHKKHKKEKKKVKDKDRDrdrdrdkdrdkKKSHS.........mkpeswSKS......PIS..ADQSLSMASSailsaER.......P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.35|      42|      48|     318|     359|       2
---------------------------------------------------------------------------
  285-  326 (63.56/40.96)	GTPSFS.SI.TSAN....SV.DLPACFFL.KFPR.PIPVS...............................raFIQK.LQGC..........T
  327-  372 (66.56/43.31)	GIPLFD.TAPTFVP....LY.ELITQFELSKEAD.PIPLN.............................hnmrFYAA.LPGQ..........Q
  373-  436 (30.04/14.59)	HCYFLNkDAP..LPdgrsLQgTLISKIAFQHPGRvPIILN..........................lirhqvaYNTL.IGSCvkrtvlkedsP
  437-  503 (36.19/19.42)	GILQFE.VC....P....LS.D..SCFSVSFQH....PVNdslvcvvmdvqdsthvncklykglsdalictddFIAKvVQRC..........M
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.29|      14|      35|     204|     222|       4
---------------------------------------------------------------------------
  204-  222 (19.00/28.18)	ILHGSVgylTPRSGGllMN
  242-  255 (28.29/18.30)	ILHESN...VPRSLG..MN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.08|      14|     102|     152|     165|       6
---------------------------------------------------------------------------
  152-  165 (25.34/18.04)	SKHLRGLVNLYKLP
  257-  270 (25.74/18.45)	SVTIEGTMAMYKLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26462 with Med1 domain of Kingdom Metazoa
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