Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAVPGGAEEAEKLNKMSTLLERLHAKYNQNRPWTETMKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVILHESNVPRSLGMNVSVTIEGTMAMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQGCTGIPLFDTAPTFVPLYELITQFELSKEADPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPIILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSAIGSSPTPPHHTPPPLSSPAGNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGSKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPATNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFAEEYFDESSQSGDTDDFKGYASQALSTLGVQVLGGDGGDNKFKGSNPSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSNMAGSGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGPSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSMKPESWSKSPISADQSLSMASSAILSAERPSRPSPEFLIGEEDDDLMDVALIGN |
Length | 1583 |
Position | Middle |
Organism | Gallus gallus (Chicken) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.637 |
Instability index | 54.54 |
Isoelectric point | 8.88 |
Molecular weight | 167988.99 |
Publications | PubMed=15592404 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 ISS:UniProtKB nucleolus GO:0005730 ISS:UniProtKB nucleoplasm GO:0005654 IEA:Ensembl nucleus GO:0005634 ISS:UniProtKB |
GO - Biological Function | chromatin binding GO:0003682 ISS:UniProtKB DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 ISS:UniProtKB peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IBA:GO_Central thyroid hormone receptor binding GO:0046966 ISS:UniProtKB transcription coactivator activity GO:0003713 ISS:UniProtKB transcription coregulator activity GO:0003712 ISS:UniProtKB transcription corepressor activity GO:0003714 ISS:UniProtKB vitamin D receptor binding GO:0042809 IBA:GO_Central |
GO - Biological Process | androgen biosynthetic process GO:0006702 ISS:UniProtKB angiogenesis GO:0001525 ISS:UniProtKB animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 ISS:UniProtKB cellular response to epidermal growth factor stimulus GO:0071364 ISS:UniProtKB cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IBA:GO_Central embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl erythrocyte development GO:0048821 ISS:UniProtKB fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 ISS:UniProtKB keratinocyte differentiation GO:0030216 ISS:UniProtKB lens development in camera-type eye GO:0002088 ISS:UniProtKB liver development GO:0001889 IEA:Ensembl megakaryocyte development GO:0035855 ISS:UniProtKB monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 ISS:UniProtKB negative regulation of apoptotic process GO:0043066 ISS:UniProtKB negative regulation of keratinocyte proliferation GO:0010839 ISS:UniProtKB negative regulation of neuron differentiation GO:0045665 ISS:UniProtKB negative regulation of transcription by RNA polymerase II GO:0000122 ISS:UniProtKB peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 ISS:UniProtKB positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 ISS:UniProtKB positive regulation of transcription by RNA polymerase II GO:0045944 ISS:UniProtKB positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 ISS:UniProtKB protein import into nucleus GO:0006606 IEA:Ensembl regulation of RNA biosynthetic process GO:2001141 ISS:UniProtKB regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 ISS:UniProtKB ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP26462 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 1148.12| 182| 182| 937| 1118| 1 --------------------------------------------------------------------------- 560- 743 (198.92/51.75) GTTTP.....TNTFPGGPITTLFNMS.....................ISMKERHDSvgHGEDfSKVSQNPIL......TSLLQITG................nvGSAIGS..SPTPPHHTPPplSS..PAGNTKnhpmlmN.LLKENPPQDF...STL..Y.GSS....P.LERQNSSSGSP.....R..ME.M.............GPGGSKQ...KKKKSRMPAD...........KPKHQteddfqrelfsmdvdSQNPI.FDVNMT..ADTLDTPHI........T.P.AP.S 744- 860 (148.33/36.62) QCSTPP............TTYPQPIPH..SQPSIQ........RMVRLSS......................................................SDSIGAdvTDIL.................S......D.IAEEAS.......K................LPATNEDCPPiGTPVR..DS.S.............SSGHSQSAL.......FDPD...........VFQTN...............NSENP.YTDPADliADAAVSPNSD.....SSN.HfFP.D 861- 1051 (263.03/70.93) GVDFNP.DLLNSQSQSGF........A..EEY..............FDESSQSGDT..DDFK.GYASQALSTlgvqvlGGDGGDNKfkgsnpsdtvdfsiiaaaSKALGS..SDIMEHHSGG..QS..PLLNTG......D.LGKEKSQKRV...KEG..N.GSG....S.NMAGSGIDGKP.GKRSR..TP.S.............SDGKSKEKLPKRKKQETDGK...........SPSHS...............SSNRP.FTPPAS..TGGSKSPGSS.....GRS.Q.TP.P 1052- 1213 (218.16/57.51) GVATPPIPKITIQIPKGTVTVGKPSSH..GQYTSS........GSVTSSSSKSHHS..HSSS.SSSSSSSST......SGKIKSSK..............segsSGSKMS..SSLYSSQ.GG..SSsgPSKSSA......QsVGKPGSSPIT...KHGlsS.GSG....StKMKP...QGKP....SSlmNP.S................MSKPNIS......................PSHS..................RP.........SGGSDKLASP.....MK.....PvP 1214- 1352 (143.47/35.16) G..TPPSSK.....AKSPISSGSGGSHmsGTGSSSsmksssgmGSSGSMSQKPPPS..SNSS.TASSSSFSS......SG...SS............................................................................mSSS....Q.NQHGSS.KGKS.PSRNK..KP.SltavidklkhgvvTSGPGGDD.P......MDGQ..........mGPSSN...............SSSH..........TMSSKHNMSG.....GEF.Q..... 1353- 1480 (120.11/28.18) .....................GKR..........................EKSDKE..KSKV.SVSGGSVDS......SKKTSDSK......nvgstgvakiiiSK............HDGG...S..PSI.............KAK....VtlqKPG..E.GGGdslrP.QMASSKSYGSP.LISGS..TP.........................KHER.....C...........SPSHS...............KS..PaYTPQNI..DSESES.GSS...iaEKSyQ.NS.P 1485- 1559 (56.10/ 9.03) GI..RPLPE.......................................................................................................................................................................................yS.............SEKHKKHKKEKKKVKDKDRDrdrdrdkdrdkKKSHS.........mkpeswSKS......PIS..ADQSLSMASSailsaER.......P --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 196.35| 42| 48| 318| 359| 2 --------------------------------------------------------------------------- 285- 326 (63.56/40.96) GTPSFS.SI.TSAN....SV.DLPACFFL.KFPR.PIPVS...............................raFIQK.LQGC..........T 327- 372 (66.56/43.31) GIPLFD.TAPTFVP....LY.ELITQFELSKEAD.PIPLN.............................hnmrFYAA.LPGQ..........Q 373- 436 (30.04/14.59) HCYFLNkDAP..LPdgrsLQgTLISKIAFQHPGRvPIILN..........................lirhqvaYNTL.IGSCvkrtvlkedsP 437- 503 (36.19/19.42) GILQFE.VC....P....LS.D..SCFSVSFQH....PVNdslvcvvmdvqdsthvncklykglsdalictddFIAKvVQRC..........M --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 47.29| 14| 35| 204| 222| 4 --------------------------------------------------------------------------- 204- 222 (19.00/28.18) ILHGSVgylTPRSGGllMN 242- 255 (28.29/18.30) ILHESN...VPRSLG..MN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 51.08| 14| 102| 152| 165| 6 --------------------------------------------------------------------------- 152- 165 (25.34/18.04) SKHLRGLVNLYKLP 257- 270 (25.74/18.45) SVTIEGTMAMYKLP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FAEEYFDE 2) ILSAERPSRPSPEFLIGEEDDDLMDVALIGN 3) IPKITIQIPKGT 4) IRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRD 5) NKKPSLTAVIDKLKHGVV 6) SIKAKVTLQK 7) VAKIIISKH 8) YGSPLI | 877 1553 1058 1486 1298 1403 1389 1431 | 884 1583 1069 1517 1315 1412 1397 1436 |
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