<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26461

Description Mediator complex subunit 23
SequenceMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREDNPWVPDDSYYCKLIGRLVAPMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVSSGSPAPQSTQVPGSLPVTQ
Length1368
PositionTail
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.10
Grand average of hydropathy-0.008
Instability index46.23
Isoelectric point7.19
Molecular weight156284.95
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26461
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.96|      19|     127|     905|     923|       1
---------------------------------------------------------------------------
  905-  923 (39.88/24.65)	KENSPEHW.LQNDWHTKHMN
 1035- 1054 (32.09/18.37)	KDNRPQGWcLSDTYLKNAMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.87|      21|     127|     584|     608|       2
---------------------------------------------------------------------------
  584-  604 (36.35/27.27)	FISQLLPTVFKSHAWGILHTL
  610-  630 (38.51/18.37)	YRMHHIQPHYRVQLLSHLHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.79|      26|      89|    1065|    1092|       3
---------------------------------------------------------------------------
 1065- 1092 (47.44/40.44)	DSYYCKLIGRLVAPMAgkSPGPFPNCDW
 1158- 1183 (47.34/32.86)	EPYWIVLHDRIVSVIS..SPSLTSETEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.64|      41|     785|     174|     214|       7
---------------------------------------------------------------------------
  174-  214 (75.92/52.49)	NACL..LPAY.FAVTEIRKLYPEGKLPHWLLGNL..VSDFVDTFRP
  925-  950 (35.48/19.99)	.................HKKYPE.KLYFEGLAEQ..VDPPVPIQSP
  958- 1001 (52.23/33.45)	NVCLrfLPVFdIVIHRFLELLPVSKSLETLLDHLggLYKFHD..RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      31|     339|     348|       8
---------------------------------------------------------------------------
  339-  348 (18.69/10.52)	IFFVLFQFAS
  372-  381 (19.45/11.27)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.62|      57|     711|      29|      89|       9
---------------------------------------------------------------------------
   29-   89 (102.93/68.60)	TPEDEKTKLISCL.GAFRQFW..AGLSQES........HEQCIQW........IVKFIHGQHSPKrisfLYDCL..AMAVET
  723-  800 (81.69/46.17)	TPHNWASHTLSCFpGPLQAFFkqNNVPQESrfnlkknvEEEYRKWksmtnendIITHFSAQRSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.69|      30|     262|     540|     573|      10
---------------------------------------------------------------------------
  540-  573 (43.29/42.17)	IHSIATRVIKLAHAKSSValapALVETYSRLLVY
  803-  832 (51.40/38.02)	INQIGYRVLERIGARALV....VHVRTFADFLVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.05|      10|      27|     135|     144|      12
---------------------------------------------------------------------------
  135-  144 (15.61/11.15)	RDLLKVILEK
  164-  173 (16.44/12.20)	REVIAYILER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26461 with Med23 domain of Kingdom Metazoa
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