<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26459

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMDLLMEKIRSKANQFKSFAECAKSIRMSQLEKRFPMDVADRHQLQKCLDTLQQSMKVTTMQGIVERLESISRQLSLKLMPGPTGLELFISSDMFYLEVSLESTGNVKDVKIHHEGKLEQQSCEELVKSLSKGDFEDFTIQLQGLISIYQLNAEKKVKCKAFSALCALEADLDAHWSLQSNTKNVLTLLNKSPVGVLLKRRGGHPMRLTYFVSPYEVLETKKELSLDLIYKSNIGCSVTICLEGSAAHKLQTAPLVSINKNSNKSSVLYAPMTPSNSATLPAYFTLKLNKPQPICLELVKQINALSELECCDSSNPHPLFSLITQFASNGKMDSSSNKGLFVNLPDQVHCYFMTECRGLDGVMLSSIPFTHPSQVPLILSILRQQAVFNGLVSSIIRPHSKQDVENMVMLEVSALSCQYLSVSFEHPLQESMSTIEIDLTDVSSIKAKLYTSTTEMNVKTSTEHISKILQRCLSIPVTMRYLIKALQNQSIDGNLNAMNNGHFSSAPNGNLGNGNDQSPIDTSKIKQENGLSNGMNGRNNTLRNQFDDFSSFSTTVIDHNIPKSTNILSFVVEQQKQKKRQKHDKHWKASKQKSIDDCEILLESSSNDSVSTDTPMEIDLETEFLVRDKDDLAENSEIDDVEEMLKVAAGPARTDIKFKKSKEVKKSPSRNSLIMDLTDGKGLVPPSVTITPITPNTPNINSVLERRPGIEIIPLTNSAAISSSITITPISSSLDKEERKNCGNKNLDEKIREKKRKRKREDENATKMGPPEKVPVKNDPLSKPVSVSIIKPATDSPPGINRPNSPSVRKYSASPTQFREKSSSSSFQPSPKHSPAYGSSPKHSPKHGTSSPKQPNSGSGKPSMSTLKSASSSPNSIKSSEGKMKTNSGSGSLGGIGKEQRDKDSSRKTTGNSSNSSTSGSPKIKSSSVKLKQLDLSGELSSSLSGRSTPPNNASTGDLKNSGNPLQRNRKGSLSAVIDKLKSAQEVSDTAPVGVKRDSSNCGSSKEGKLPSGLCGATLSKIGLEGKALSIQKIPDGIKNPGEYMVKQSSDGMKLLINKKSKEGSKITKSGSSSGTGFFKTHTGLKPGVISGPASKKSTSKSNSLSGMSSKGSSSLSKNSTIKSSIAKSLSSKGSGSPKIITSAITDLTRKENSGKSRSLKINSDKTLFKEGMRKGSPAPVRDEDHERAIKTLKIESGFPPSEKISDKSEIKIMDIPASKTSLDLAANLKYQTSKHDAKIPSSNVPNLLSLPMALTNVSPKLPMTSPNLPTTSLSSITSKLDRGEDSKFVEATIVDKMENDGSSTTTVDVTSVKFQTSNTPLPKSDDVKKSFDISKHLISTQQPPEMLIDFSNSLTGKILTDKSEKALVVGVTTPTCFVKPNSPAIFQKSPVQSPMDVPSQSPQSITDDELMDEAID
Length1416
PositionMiddle
OrganismPediculus humanus subsp. corporis (Body louse)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Psocodea> Phthiraptera> Anoplura> Pediculidae> Pediculus.
Aromaticity0.04
Grand average of hydropathy-0.537
Instability index47.09
Isoelectric point9.28
Molecular weight153598.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26459
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     112.27|      19|      19|    1094|    1112|       2
---------------------------------------------------------------------------
  871-  889 (28.27/ 9.53)	SSPNSIKSSEGKMKTNSGS
  905-  920 (24.09/ 6.99)	SRKTTGNS...SNSSTSGS
 1094- 1112 (31.63/11.59)	SKKSTSKSNSLSGMSSKGS
 1116- 1134 (28.28/ 9.54)	SKNSTIKSSIAKSLSSKGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     394.58|     104|     176|     119|     293|       3
---------------------------------------------------------------------------
  172-  279 (161.53/130.27)	DAHWSLQSNTKNVL....TLLNKS.........PVGV..llkRRGGHPMRLTYFVSPYEVLETKKELS.LDLIYKSNIGCSVTiCLEGSAAHKLQTAPLVSINKNSN.............KSSVLYAPMTPS....N.SATL
  583-  701 (102.36/30.30)	DKHW..KASKQKSIddceILLESSsndsvstdtPMEI..........DLETEFLVRDKDDLAENSEIDdVEEMLKVAAGPART.......DIKFKKSKEVKKSPSRNslimdltdgkglvPPSVTITPITPNtpniN.S...
 1158- 1261 (130.69/47.13)	....SLKINSDKTL.fkeGMRKGS.........PAPVrdedhERAIKTLKIESGFPPSEKISDKSEIK.I.....MDIPASKT.SLDLAANLKYQTSKHDAKIPSSN.............VPNLLSLPMALT....NvSPKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.53|      54|     177|     292|     346|       4
---------------------------------------------------------------------------
  292-  327 (57.11/35.93)	....................PICLELVKQINALS.....ELEC..CD....SSNP..HP.....LFSLITQFAS
  328-  386 (42.73/29.58)	NGKMDSSSNkGLFVNLPDQ...............vhcyfMTECrgLDgvmlSSIPftHPsqvplILSILRQQAV
  499-  531 (43.68/25.57)	NGHFSSAPN.GNLGNGNDQsPIDTSKIKQENGLS........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.15|      53|      76|     958|    1015|       5
---------------------------------------------------------------------------
  958- 1015 (77.41/60.35)	LKNSGNPLQRNRKGSLSAVIDKlKSaQEVSDTAPVGvkrDSSNCG..SSKEGKLPSGLCG
 1037- 1091 (85.74/50.84)	IKNPGEYMVKQSSDGMKLLINK.KS.KEGSKITKSG...SSSGTGffKTHTGLKPGVISG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.98|      15|      54|     790|     804|       7
---------------------------------------------------------------------------
  790-  804 (28.02/16.13)	KPATDSPPGINRPNS
  808-  821 (17.17/ 6.41)	RKYSASPTQFREKS.
  845-  856 (22.79/11.45)	KHGTSSP...KQPNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.60|      30|     408|     921|     951|       8
---------------------------------------------------------------------------
  921-  951 (50.15/29.34)	PKIKSSSVKlKQLDLSGEL.............SSSLSGR..............STP.....PN
 1320- 1381 (32.44/13.71)	PLPKSDDVK.KSFDISKHListqqppemlidfSNSLTGKiltdksekalvvgvTTPtcfvkPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.30|      30|     429|      44|      79|       9
---------------------------------------------------------------------------
   44-   79 (40.88/46.58)	LQKCLdtlqqSMKVtTMQGIVERLESISRQLSLKLM
  468-  497 (53.42/39.13)	LQRCL.....SIPV.TMRYLIKALQNQSIDGNLNAM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26459 with Med1 domain of Kingdom Metazoa
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