Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MDLLMEKIRSKANQFKSFAECAKSIRMSQLEKRFPMDVADRHQLQKCLDTLQQSMKVTTMQGIVERLESISRQLSLKLMPGPTGLELFISSDMFYLEVSLESTGNVKDVKIHHEGKLEQQSCEELVKSLSKGDFEDFTIQLQGLISIYQLNAEKKVKCKAFSALCALEADLDAHWSLQSNTKNVLTLLNKSPVGVLLKRRGGHPMRLTYFVSPYEVLETKKELSLDLIYKSNIGCSVTICLEGSAAHKLQTAPLVSINKNSNKSSVLYAPMTPSNSATLPAYFTLKLNKPQPICLELVKQINALSELECCDSSNPHPLFSLITQFASNGKMDSSSNKGLFVNLPDQVHCYFMTECRGLDGVMLSSIPFTHPSQVPLILSILRQQAVFNGLVSSIIRPHSKQDVENMVMLEVSALSCQYLSVSFEHPLQESMSTIEIDLTDVSSIKAKLYTSTTEMNVKTSTEHISKILQRCLSIPVTMRYLIKALQNQSIDGNLNAMNNGHFSSAPNGNLGNGNDQSPIDTSKIKQENGLSNGMNGRNNTLRNQFDDFSSFSTTVIDHNIPKSTNILSFVVEQQKQKKRQKHDKHWKASKQKSIDDCEILLESSSNDSVSTDTPMEIDLETEFLVRDKDDLAENSEIDDVEEMLKVAAGPARTDIKFKKSKEVKKSPSRNSLIMDLTDGKGLVPPSVTITPITPNTPNINSVLERRPGIEIIPLTNSAAISSSITITPISSSLDKEERKNCGNKNLDEKIREKKRKRKREDENATKMGPPEKVPVKNDPLSKPVSVSIIKPATDSPPGINRPNSPSVRKYSASPTQFREKSSSSSFQPSPKHSPAYGSSPKHSPKHGTSSPKQPNSGSGKPSMSTLKSASSSPNSIKSSEGKMKTNSGSGSLGGIGKEQRDKDSSRKTTGNSSNSSTSGSPKIKSSSVKLKQLDLSGELSSSLSGRSTPPNNASTGDLKNSGNPLQRNRKGSLSAVIDKLKSAQEVSDTAPVGVKRDSSNCGSSKEGKLPSGLCGATLSKIGLEGKALSIQKIPDGIKNPGEYMVKQSSDGMKLLINKKSKEGSKITKSGSSSGTGFFKTHTGLKPGVISGPASKKSTSKSNSLSGMSSKGSSSLSKNSTIKSSIAKSLSSKGSGSPKIITSAITDLTRKENSGKSRSLKINSDKTLFKEGMRKGSPAPVRDEDHERAIKTLKIESGFPPSEKISDKSEIKIMDIPASKTSLDLAANLKYQTSKHDAKIPSSNVPNLLSLPMALTNVSPKLPMTSPNLPTTSLSSITSKLDRGEDSKFVEATIVDKMENDGSSTTTVDVTSVKFQTSNTPLPKSDDVKKSFDISKHLISTQQPPEMLIDFSNSLTGKILTDKSEKALVVGVTTPTCFVKPNSPAIFQKSPVQSPMDVPSQSPQSITDDELMDEAID |
Length | 1416 |
Position | Middle |
Organism | Pediculus humanus subsp. corporis (Body louse) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Psocodea> Phthiraptera> Anoplura> Pediculidae> Pediculus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.537 |
Instability index | 47.09 |
Isoelectric point | 9.28 |
Molecular weight | 153598.94 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP26459 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 112.27| 19| 19| 1094| 1112| 2 --------------------------------------------------------------------------- 871- 889 (28.27/ 9.53) SSPNSIKSSEGKMKTNSGS 905- 920 (24.09/ 6.99) SRKTTGNS...SNSSTSGS 1094- 1112 (31.63/11.59) SKKSTSKSNSLSGMSSKGS 1116- 1134 (28.28/ 9.54) SKNSTIKSSIAKSLSSKGS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 394.58| 104| 176| 119| 293| 3 --------------------------------------------------------------------------- 172- 279 (161.53/130.27) DAHWSLQSNTKNVL....TLLNKS.........PVGV..llkRRGGHPMRLTYFVSPYEVLETKKELS.LDLIYKSNIGCSVTiCLEGSAAHKLQTAPLVSINKNSN.............KSSVLYAPMTPS....N.SATL 583- 701 (102.36/30.30) DKHW..KASKQKSIddceILLESSsndsvstdtPMEI..........DLETEFLVRDKDDLAENSEIDdVEEMLKVAAGPART.......DIKFKKSKEVKKSPSRNslimdltdgkglvPPSVTITPITPNtpniN.S... 1158- 1261 (130.69/47.13) ....SLKINSDKTL.fkeGMRKGS.........PAPVrdedhERAIKTLKIESGFPPSEKISDKSEIK.I.....MDIPASKT.SLDLAANLKYQTSKHDAKIPSSN.............VPNLLSLPMALT....NvSPKL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 143.53| 54| 177| 292| 346| 4 --------------------------------------------------------------------------- 292- 327 (57.11/35.93) ....................PICLELVKQINALS.....ELEC..CD....SSNP..HP.....LFSLITQFAS 328- 386 (42.73/29.58) NGKMDSSSNkGLFVNLPDQ...............vhcyfMTECrgLDgvmlSSIPftHPsqvplILSILRQQAV 499- 531 (43.68/25.57) NGHFSSAPN.GNLGNGNDQsPIDTSKIKQENGLS........................................ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 163.15| 53| 76| 958| 1015| 5 --------------------------------------------------------------------------- 958- 1015 (77.41/60.35) LKNSGNPLQRNRKGSLSAVIDKlKSaQEVSDTAPVGvkrDSSNCG..SSKEGKLPSGLCG 1037- 1091 (85.74/50.84) IKNPGEYMVKQSSDGMKLLINK.KS.KEGSKITKSG...SSSGTGffKTHTGLKPGVISG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 67.98| 15| 54| 790| 804| 7 --------------------------------------------------------------------------- 790- 804 (28.02/16.13) KPATDSPPGINRPNS 808- 821 (17.17/ 6.41) RKYSASPTQFREKS. 845- 856 (22.79/11.45) KHGTSSP...KQPNS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 82.60| 30| 408| 921| 951| 8 --------------------------------------------------------------------------- 921- 951 (50.15/29.34) PKIKSSSVKlKQLDLSGEL.............SSSLSGR..............STP.....PN 1320- 1381 (32.44/13.71) PLPKSDDVK.KSFDISKHListqqppemlidfSNSLTGKiltdksekalvvgvTTPtcfvkPN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 94.30| 30| 429| 44| 79| 9 --------------------------------------------------------------------------- 44- 79 (40.88/46.58) LQKCLdtlqqSMKVtTMQGIVERLESISRQLSLKLM 468- 497 (53.42/39.13) LQRCL.....SIPV.TMRYLIKALQNQSIDGNLNAM --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IKTLKI 2) MKLLINK 3) SDKTLFKE 4) TGFFKTHTGLKP 5) VKLKQL | 1189 1052 1163 1075 928 | 1194 1058 1170 1086 933 |
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