<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26451

Description "Mediator of RNA polymerase II transcription subunit, putative"
SequenceMVFSNEKRPLKRSRLGPPDVYPQDPKQKEDELTVNNVKLGFTTMPQLSDEFGTARNCNVTPSKVGSYFNAILSKKEELNTLPDSGRKRQQINTKDNFWPATARTKNAIENWFKDLAGNKPLLNLSKKAPNFNKKEEIFILLCEYNVPLMRAAWFVKLSSAYTVAVSEAKMKKRQLPDPTQEWTSTLIKFLKDQLIKLQEYYHQSWGPTLTATEEQKLALKQWRYCTTLAKYLYEENLLERIEFLNWILELLDKLKSSNHEDGMLRILLPLCLQYLDEFVQSELLSRRLSHLCCKKLGQLALRGGLFPKEDSSSNLNIQLSSGGNPMLGVVSANNSGTLMNGSRNCNNTNISVNSNSNNNDSNINTTNSGTLQTSGNYMIGNSSNNQQMVSANVGQSTGNSVNNTVTVITTVQAARAIITTITTSIAIATTIAAIVATTTNSQIQVSSYFNELMQCSHHRDVVIYLSTIIQVITLECPTALVWNCIGEGRSTHPLNNSPLDHLPCPPSTLPMPARASNSSLRQQIKQAEEAIKARSRAAEVRWSCDKWQQSTDGQTTTKVLNALDSLDRHSFDKTDSNNNLDTLYSKIFSNISTKEGGNQSDSRSDSAVIQEEPIVEILCEWAVSNVRYGEHRAMAVAMLLEKRQAHLTGEGGDCDDKDSISSGNVVQNSLPIFQGLLMKFLDNDAPILEENGSIQNKVMFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLPTNSQTTGGNYNNKPDTPNDGRVPPNSVDEEASLFPRIDLKPPKMEGHDYDDSKIDDDLDKLLQHIKEEQQNSMDAPDSPKDVGISHGVFCTQPSRHLLYTTHFPLPQDEGSSHDCNQRHVLLYGVGKVRDDARHSLKKMSKEICKLFNKKFSIDVVDGGKVKKYSRNEFNFESVTNKFQSFSFFDQHVITWQCSLIVLEMLASFAGGISNYLPVQEHIAFLFDLMELAYNIYGLIHVCIQILKELPEVENQLGLKGYSLDRCYTTGLALYIVAVLRRYHSCLLLSREQTVMVFQGLCNVVKHVTNPADCSSAERCILVHLYDLYSSCSILKCKPHCVEAFQNAYPKIKQALYCTIQPSPSSHVYNSGFMAEIFTNPRRNGKIEPQWGRQLAESASNRYSLVCNAILAVVSENDNDRLNDIALTCAELTACCNSLSAEWLGVLQALFSSSSESCYFIDVLQQVDVQDFSIHNSLAVFVSILIARHCFSLVDFIQIAIPPIVRRGKDLEDEAGARLTCHLLLRLFKTVECPQPALYSGGTSPHPLEVFCMKLSCDRHLLAATHSTIHVGAVLAVLKAILVVADLTSKHSKPLKKEPTNKITTPLGSGELSISHILGTSDILGGGHDLLGLGSASACRSNETTTSLSDFAQHVLKQICSQEWVLERCLQNPEELCQPDMLLDNELTPRQAQRLLHMICYPNSTLDNNLDQRTMISRILESLDLWTLRISWLDLQLMYKQFSIGSSELNHWLDIVAKAAIDVFQLNSNEITFVKGEKIPTSKKNKNGNIWLVAPLVSKLPSAVQGRVLRVAGQVLESGNWSGKSRERDRSAQRSTSLLSHQPFLSLVLTCLKGQDDQREGLLTSLHNQLTQYIQLSKDERLSNYEDGKGRALMQDSLQLRFSLVGGMFDTVQRSSSTTTEWAILLLQLVTYGVIDLNNNSELFTSVVDMLATLIHSTLISDSQSDKSDENKKHYLNLMKKLKKEIGDKISPSMMQVRQLLPLSKKQLEVVTVQPVGCLTDTKGNKIAGFDSIDKKQGLQVYEKQKVLPWEILEGHKNPAPLSWAWFGAIRIERKPLWYQDAHRLLKFHTHNVTKPASYYLDPPPLPPEDLEPVPEKPCSCVYCNQMKDDKADTPSSDTSPRGKKGVKKNLKRRAKNEPMTPQPTMQANMQPQIQIQQQMSYPNQNPMFTAQQGQLINQQQGVNQQWGYGQQPAQQMIPQQNIPGVQQQAYYPQQLNQQVAAPRFERPLNQQSKQAITNMLRMRIPAQQFMGQQPFGQTPQPPMQQRQQFIRRSLEGVQQLRSQQVGMQNAAMFPQGNMYSNMQQSLNQNYGGYGSQQINTQQMINQQGGMSNINFSQHQGFQQGGNAPGGGGTLMTGGPMQRTEYMQTSGPCINQQRGIGPQRSYLQAPNVTMNTMGGTMTGPAPPYPRAPGPNAGPQMNPQQGQQFQVNSQRMRQQLIAMQQAQGNNPNNQTLGNPNQQPTPALMAQLQRQTQMPVQNPFLLKTKSCRLFNNNWNWKRKALNQRLLWFYITALP
Length2263
PositionKinase
OrganismPediculus humanus subsp. corporis (Body louse)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Psocodea> Phthiraptera> Anoplura> Pediculidae> Pediculus.
Aromaticity0.07
Grand average of hydropathy-0.436
Instability index46.72
Isoelectric point8.38
Molecular weight253722.02
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26451
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     105.89|      20|      20|    1924|    1943|       1
---------------------------------------------------------------------------
 1890- 1912 (24.58/ 8.33)	QP...TM..Q.ANMQPqiQIQQQMSYpNQ
 1913- 1938 (28.05/10.68)	NPmftAQqgQlINQQQ..GVNQQWGY.GQ
 1939- 1961 (27.07/10.02)	QP...AQ..QmIPQQNipGVQQQAYY.PQ
 2063- 2080 (26.19/ 9.42)	.....SQ..Q.INTQQ..MINQQGGM.SN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.00|      17|      27|     811|     831|       2
---------------------------------------------------------------------------
  811-  831 (27.08/29.22)	PKDVGISHGvfCTQpsRH.LLY
  838-  855 (32.92/19.08)	PQDEGSSHD..CNQ..RHvLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.54|      21|      25|    1403|    1423|       3
---------------------------------------------------------------------------
 1403- 1423 (38.79/22.32)	LCQPDMLLDNELTPR.QAQRLL
 1426- 1447 (34.76/19.21)	ICYPNSTLDNNLDQRtMISRIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     162.29|      25|      25|    2167|    2191|       4
---------------------------------------------------------------------------
 1978- 1996 (24.75/ 8.13)	...QQSKQAITNM....LRMR...IPAQQ
 2011- 2037 (32.39/12.83)	M..QQRQQFIRRSlegvQQLRSQQVGMQN
 2040- 2057 (22.99/ 7.04)	MFP.QGNMYSNMQ....QSLNQN......
 2167- 2191 (48.66/22.86)	MNPQQGQQFQVNS....QRMRQQLIAMQQ
 2203- 2226 (33.50/13.52)	GNPNQQPTPALMA....QLQRQTQMPVQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.09|      23|      27|     233|     257|       6
---------------------------------------------------------------------------
  233-  257 (30.89/34.23)	YEENLLeRIeFLNWILELLDKLKSS
  259-  281 (42.20/33.48)	HEDGML.RI.LLPLCLQYLDEFVQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.79|      21|      27|    1017|    1041|       7
---------------------------------------------------------------------------
 1017- 1038 (33.00/21.28)	SREQTVMV.FQGL...CNVVKHvTNP
 1043- 1066 (28.10/18.43)	SAERCILVhLYDLyssCSILK..CKP
 1306- 1321 (21.70/ 9.79)	...KAILV.VADL...TS..KH.SKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.52|      17|      19|    2121|    2137|       8
---------------------------------------------------------------------------
 2109- 2129 (23.66/10.68)	QRTeYMQTSgpcINQQR..G..IGP
 2130- 2151 (24.26/11.16)	QRS.YLQAPnvtMNTMG..GtmTGP
 2152- 2165 (18.60/ 6.61)	APP.YPRAP........gpN..AGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.87|      18|      19|    1459|    1476|       9
---------------------------------------------------------------------------
 1170- 1184 (21.16/ 9.27)	WLGvL..QAL...FS.SSSES
 1459- 1476 (33.03/18.55)	WLD.L..QLMYKQFSIGSSEL
 1479- 1498 (23.68/11.24)	WLD.IvaKAAIDVFQLNSNEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.75|      24|      26|     759|     784|      10
---------------------------------------------------------------------------
  759-  784 (38.67/34.71)	VDEE.ASLFPRIdlKPPKMEGHDYDDS
  786-  810 (37.08/25.47)	IDDDlDKLLQHI..KEEQQNSMDAPDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.71|      15|      27|    1829|    1844|      11
---------------------------------------------------------------------------
  500-  512 (24.25/ 8.07)	DHLPCPPSTL.PMP.
 1829- 1843 (30.31/13.16)	DPPPLPPEDLEPVPE
 1857- 1871 (25.14/ 6.68)	DKADTPSSDTSPRGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.66|      15|      27|     541|     563|      13
---------------------------------------------------------------------------
  541-  555 (30.89/27.31)	RWSCDKWQQSTDGQT
  568-  582 (26.77/ 7.81)	RHSFDKTDSNNNLDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.05|      22|      27|    1687|    1708|      19
---------------------------------------------------------------------------
 1687- 1708 (36.05/25.13)	ISDSQSDK....SDENKKHYLNLMKK
 1713- 1733 (33.50/22.72)	IGDKIS.P....SMMQVRQLLPLSKK
 1746- 1771 (27.50/17.06)	LTDTKGNKiagfDSIDKKQGLQVYEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.20|      17|      20|     407|     425|      21
---------------------------------------------------------------------------
  407-  425 (21.65/21.65)	VITTVQAarAIITTITTSI
  427-  443 (26.55/18.45)	IATTIAA..IVATTTNSQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.88|      19|      20|     947|     966|      22
---------------------------------------------------------------------------
  947-  966 (28.76/23.15)	QEHIAFLFDLMELAyNIYGL
  968-  986 (33.12/20.89)	HVCIQILKELPEVE.NQLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.82|      14|      19|    1505|    1521|      23
---------------------------------------------------------------------------
 1505- 1521 (19.90/20.11)	KIPTSKKnknGNIWLVA
 1526- 1539 (22.92/13.03)	KLPSAVQ...GRVLRVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.25|      14|      37|    1245|    1258|      24
---------------------------------------------------------------------------
 1245- 1258 (25.03/13.71)	RLTC..HLLLRLFKTV
 1281- 1296 (20.22/ 9.73)	KLSCdrHLLAATHSTI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26451 with Med12 domain of Kingdom Metazoa
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