<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26442

Description "Mitogen-activated protein kinase ERK-A, putative"
SequenceMDYDFKFKTANERAKVEDLFDYEGCKVGRGTYGHVYKARRKDGSDMKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHNDRKVWLLFDFAEHDLWHIIKFHRAAKANKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPLEKDWEDIRKMPEYQTLVKDFKKSNYSSCSLVKYMDRHKIKPDSKAFHLLQKLLLMDPTKRITSEQAMQDSYFSEEPTPTADVFAGCMIPYPKREFLTDDDQDEKSDSKARQNAAANQQTAQSNQSDGPNAKRVRLQPPPLVSTSQQSQGQEFHHVNTQQQMVFTSAASTQQSNFQQR
Length440
PositionKinase
OrganismPediculus humanus subsp. corporis (Body louse)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Psocodea> Phthiraptera> Anoplura> Pediculidae> Pediculus.
Aromaticity0.10
Grand average of hydropathy-0.575
Instability index45.20
Isoelectric point8.77
Molecular weight50781.47
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:UniProtKB-EC

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26442
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.36|      25|      39|     101|     138|       1
---------------------------------------------------------------------------
  102-  129 (42.73/53.20)	HDLWhiiKFHRAAKANKKPVM..VP.KGMVK
  143-  170 (38.63/15.09)	HSNW...VLHRDLKPANILVMgeGPeRGRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.74|      15|      39|     232|     247|       2
---------------------------------------------------------------------------
  232-  247 (25.18/20.53)	PIFHCRQEDIKTSNpY
  274-  288 (27.57/16.67)	PEYQTLVKDFKKSN.Y
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26442 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EFLTDDDQDEKSDSKARQNAAANQQTAQSNQSDGPNAKRVRLQPPPLVSTSQQSQGQEFHHVNTQQQMVFTSAASTQQSNFQQR
357
440










Molecular Recognition Features






MoRF SequenceStartStop




1) PNAKRVRLQPPPLVSTSQ
391
408