<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26438

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSAEDNHWKSATFRQGVVAKIDDAVARSGMPTSKNSMEMENHVFQKAKTKEEYLAFVARLILHIREMKTKNSNAIGGSGVSGQIVPDPINALQTLARQGTGNNQIINMTPGEMPNGPVGIVRQTPPQNAATNCYCLTLQIISNFKFSVLQTLNQRPSPNAMMGLPGVQNKMGGINMVPVQQPGGINQIPVPNIGSQIHPSMQGQLNSQINVPIGPQLHSQMNQIQQRKANEMIIGTQPGSFLGSRNAPPNQFLRQSPSPSAVSPVGVGSVGSNQMAVSPALVSSPSGPQLTPVMSGPPRSNGMASSPSNSLNTPGQSVPTPSPGNLLEEQQYREKVRQLSKYIEPLRKMIAKMGNDDVEKLSKMKKLLEILSNPSKRMPLETLRKCEVVLEKLDLKRGEGSVGSHPGHISALKEIHNLNPLLEAVNNCLQTSVNNHTLQRTFGPTMDTLFGTEMKMLPTPLERKVTEDVKHDIPEVLQGEIARLDQRFKVSLDNIQQPGSKNIRLICWLDDKYLPCVPPISISIPEDYPKNPPRCTLSQQEYMATDFLMAIHKALSLRIRKLPNKYSLSQLLDTWEMSVRQASAPSLKAPSTASVLMAL
Length599
PositionTail
OrganismPediculus humanus subsp. corporis (Body louse)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Psocodea> Phthiraptera> Anoplura> Pediculidae> Pediculus.
Aromaticity0.04
Grand average of hydropathy-0.394
Instability index58.02
Isoelectric point9.47
Molecular weight65508.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26438
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     114.19|      19|      19|     186|     204|       1
---------------------------------------------------------------------------
   73-  100 (19.82/ 6.51)	N.AIGGSGVSGQIVPdpinalqtlAR.QGT
  153-  170 (30.57/14.19)	N.QRPSPNAMMGL.P.........GV.QNK
  186-  204 (39.44/20.54)	N.QIPVPNIGSQIHP.........SM.QGQ
  206-  225 (24.35/ 9.75)	NsQINVP.IGPQLHS.........QMnQIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.97|      24|      26|     256|     279|       2
---------------------------------------------------------------------------
  256-  279 (45.63/21.34)	SPSPSAVSPVGVGSVGSNQMAVSP
  284-  307 (48.34/23.02)	SPSGPQLTPVMSGPPRSNGMASSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.91|      16|      26|     334|     349|       3
---------------------------------------------------------------------------
  334-  349 (27.55/18.18)	EKVRQLSKYIE....PLRKM
  359-  378 (21.37/12.50)	EKLSKMKKLLEilsnPSKRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.07|      22|      29|     530|     554|       8
---------------------------------------------------------------------------
  530-  554 (35.23/33.82)	KNPPRCTLSQqeyMATDFLMAIHKA
  561-  582 (38.84/27.07)	KLPNKYSLSQ...LLDTWEMSVRQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26438 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQMAVSPALVSSPSGPQLTPVMSGPPRSNGMASSPSNSLNTPGQSVPTPSPGNLLEEQQYRE
2) QIPVPNIGSQIHPSMQGQLNSQINVPIGPQLHSQMNQIQQRKANEMIIGTQPGSFLGSRNAPPNQFLRQSPSPSAVSPVGVGSV
273
187
334
270










Molecular Recognition Features






MoRF SequenceStartStop




NANANA