<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26435

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRTDLCGIKWRKLVHGETGFAPEPSEDPILSSFSRCLAADILCVWRRVATAVPPSSDINGGLFDNIALQTAPVKHPPLSLHAAKELWIFWYGEEPDLSGLVSPELLASEGQQGSWETGLNYECRSLLFKALHNLIERCLLSRDCVRLGKFFVQPHEGHEKILGKNTYLSFSFAFFVHGESTVCASVDVREHPPVYSLTRQHLAAAQASTTGTPVILAPNGLAGNLTGVAYKNSDSTASRFLEEWRKFYPIHSKYLGRDPDPGLPPPVVEILVGGVKMKYPSCYVLVTDMDDQGTPVAPTSCLLGKASPGANNNNNNNNNNKKMSSGPASPPCSPCPNKKKPTLVTPSIMASEYHAISSGYHLKSMHNTQPAAVRMPEWVWQDSILNALDPDSEEKASTQLGQWDFTDPTRKATCNCSKCKKNQSWKIGCGGSSSMGNVKTEQKTPRRIPFHRRPDDDGFEGPIVRSTAGSGTPCGPPSYLRGQSMTPNAVPSIHSTGLNDSLPVPSVGSPASAAPSPLPNPHSQPASIPPADPTMPTLSPHPPASNSQPNQPSTPMETHDKSTPAATPDVPNPKSVSSANQAFSPYPNSNSGDNKITNTNENIPLQPVVNNVQPSPSNSFPILKRPILAWKEYENLVIEEEHQPSEYLYDYSTLDAWLNYPVKKFKPDTKESRKRSYLGDLYASHQPNRAPTPPPQTIKIQVKQEPSSVASDTSEPCQVGTPAPGVKRSDPYEFDDDVTAANDEDRKFDGSNGTSKCTSGNLFTSEGLTASYRDLDQIFDNSDDTSSDEPVQVPTPPNSNKPAGFMEENSQTLLVKPPRGSGGATHAGILRPEELCKMFPTPPSMEHNPIASPSGHLSDGQVNEMTDGPIITRFKQEIYPNLGSPQEEPIEDWSYVFRPPLMYKMVGSSKYAPLTNLPSQNLPPITLPSNCVYKPSWLQPQEKPTSTSSQATSSSTTTTTTMTTTTTTNNSTTNTPSRPGSVAHQHVPRTGLSPISPAGHFPPSPMMTNMFKGPGSVGGGVRTPCPPPLYEMPSPATSTASSYLNKNINSVEPAPTPVVARAPEANSLVVNILLSDTGFNIFRDHNFDSCTLCVCNAGPKCVGNIRGADAAFYLQTHHEEDSIRCNCGFSAVVNRRLSHKSGLFYEDELEITGLAEDPNERRKNSLFSYLASMNKENINMDSSVSESLDIIPQNILELLREQFVVIQNSSNSLHRAARLYRNYTNVIPYPTMVNVLEFTDCNDVTVLALEQGRLSMETSSAICKTEDSLMRHSKVPCLPSVHRWPYLRARGPQCNQDIVRVMKNLQPILQEAIQKKCTTRLWEAPYTVSGPLTWRQFHRLAGRGTDDRCEPQPIPSLLVGYEKDWLSLSPYALHFWDKLLLEPYSYSRDVAYIVVTPENDFILQKVRTFFKELSSTYEVCRLGRHSPITKVLRDGILRVGKAAATKLSKEPVDEWFTNLGDNSICNLLKLYAQACKYHLAPHLSQVTMDKTLLDPPEGITKVEKPTPPPTSTDSTINVVPERAPSTPISDIETENPTIGSSCQGPIDYGHDEDDSDPPTVVIYLVEPFTLGSDNVDLQRLSLLALLRCYSAVLSSVPESVRSNISVQIISLESIFELGKARESTRLNDHMRSLALSVFSQCRRLLVHTSNVKSLTGFGSAALADLFLKNKDEKNRAPYRLYSPPYILAPHKERVESNESFGKSNPQHCSVLYVSYCLSEDQRMLLTVATDDTGSIFESQTINIEIPNRSRRKKASARRVGLQKLMDFILGIISQSVQPWRLVVGRIGRIGHGELKGWSWLLSRKALLKASKHLREICNQCSLLSPTDVPCILSACLVSLEPDSALRLMPDQFTPDERFSQTSVNCQLSTPHDVTCTHILVFPTSATSQSSQTAFNEQHINGPDLGDDDIFSALNEDDVEDINGIQDLNDIFSTWPDACPGGVQSPTGSPRRNDSMSQQGSPSCNMEGNMDQQGSFPCNVPSRNGGGSDGQEEVGTLLQQPLALGYFVSTAPTGPMPSWFWASCPHLENVCPAFLKNALHMHSPSIQQSSDELLQQQSAVTDHPLDSQFTTDVLRYVLEGYNALSWLALDSNTHDRLSCLPVHVQVLMQLYHMTATLV
Length2117
PositionMiddle
OrganismPediculus humanus subsp. corporis (Body louse)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Psocodea> Phthiraptera> Anoplura> Pediculidae> Pediculus.
Aromaticity0.07
Grand average of hydropathy-0.444
Instability index56.47
Isoelectric point5.88
Molecular weight232551.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26435
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.93|      27|      27|     519|     545|       1
---------------------------------------------------------------------------
  445-  496 (28.32/ 6.92)	PRRIPfhrrPDDdgfegpivrSTAGSGTPC.G.PPSylrgqsmtpnavPSIHST
  525-  554 (46.26/16.34)	PASIP....PAD.........PTMPTLSPH.P.PAS.........nsqPNQPST
  555-  592 (27.35/ 6.41)	P..ME....THD.........KSTPAATPDvPnPKS.vssanqafspyPNSNSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     439.22|     133|     653|     190|     354|       2
---------------------------------------------------------------------------
  190-  276 (51.08/58.70)	.......................................................................................................................EHPPVYSlTRQHLAAAQAS.TTGTPVIlapnglagnltgvayknsdstaSRFLEEwrkFY..PIhsKYLG...RDP..DPG..LPPPVVEILVGGVK
  280-  354 (97.26/36.98)	PScYVLVTDMDDQGTP..VAPTS.CLLGK..ASPGANNNNNN.....NNNNKKMSSGPASPPCSPCPNKKKPTLVTPSIMASEYH...................................................................................................................................
  743-  910 (149.94/62.16)	........DEDRKFDG..SNGTSkCTSGNlfTSEGLTASYRDldqifDNSDDTSSDEPVQVP.TP.PNSNKPA....GFMEENSQtllvkpprgsggathagilrpeelckmfptppsmEHNPIAS.PSGHLSDGQVNeMTDGPII......................TRFKQE...IY..P....NLGspqEEPieDWSyvFRPPLMYKMVGSSK
  911-  984 (77.15/23.35)	...YAPLTNLPSQNLPpiTLPSN.CVYKP..SWLQPQEKPTS.....TSSQATSSSTTTTTTMTTTTTTNNSTTNTPSRPGSVAH...................................................................................................................................
 1524- 1565 (63.79/22.49)	PS..TPISDIETE.NP..TIGSS.C..........................................................................................................................................................qgPI..DY.G...HDE..DDS..DPPTVVIYLV....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.74|      12|      27|    1095|    1106|       3
---------------------------------------------------------------------------
 1095- 1106 (25.20/14.78)	CNAGPKCVGNIR
 1125- 1136 (24.54/14.18)	CNCGFSAVVNRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.18|      12|      27|     994|    1005|       4
---------------------------------------------------------------------------
  994- 1005 (25.89/11.75)	PISPAGHFPPSP
 1024- 1035 (27.30/12.91)	PCPPPLYEMPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.99|      27|    1845|      88|     114|       5
---------------------------------------------------------------------------
   88-  114 (50.95/24.63)	IF..WYGEEPD..LSGLVSPELLASEGQQGS
 1930- 1960 (46.04/21.54)	IFstWPDACPGgvQSPTGSPRRNDSMSQQGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.36|      23|      30|     629|     655|       6
---------------------------------------------------------------------------
  629-  651 (43.34/31.56)	AWKEYENLVIEEEHQPSE...YLYD.Y
  656-  682 (34.03/14.53)	AWLNYPVKKFKPDTKESRkrsYLGDlY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.13|      22|    1503|     498|     522|       7
---------------------------------------------------------------------------
  498-  522 (36.85/22.35)	LNDSLpvpSVGSPASAAPS.PLPN......PH
 1997- 2025 (34.28/13.20)	LQQPL...ALGYFVSTAPTgPMPSwfwascPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.43|      37|    1503|     122|     179|       8
---------------------------------------------------------------------------
  123-  165 (56.75/84.11)	CRslLFKalHNLIERCLlsRDCV.RLG.....KFFVQPHEGHEKILGKN
 1420- 1462 (58.68/28.75)	CR..LGR..HSPITKVL..RDGIlRVGkaaatKLSKEPVDEWFTNLGDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.04|      10|      31|     686|     695|       9
---------------------------------------------------------------------------
  686-  695 (19.78/ 9.80)	QPNRAPTPPP
  715-  724 (20.26/10.28)	EPCQVGTPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.68|      14|      31|    1076|    1089|      10
---------------------------------------------------------------------------
 1076- 1089 (26.91/16.20)	DTGFNIFRDHNFDS
 1109- 1122 (25.77/15.22)	DAAFYLQTHHEEDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.96|      12|     651|     832|     843|      11
---------------------------------------------------------------------------
  832-  843 (27.24/15.91)	PEELCKMF.PTPP
 1496- 1508 (20.73/ 9.82)	PEGITKVEkPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.33|      37|     358|    1320|    1361|      15
---------------------------------------------------------------------------
 1320- 1361 (62.87/42.56)	RLWEAPYTVSgpltwRQFHRLAGRGTDDRCEPQPIPSLLVGY
 1679- 1715 (67.45/34.34)	RLYSPPYILA.....PHKERVESNESFGKSNPQHCSVLYVSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26435 with Med13 domain of Kingdom Metazoa
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