<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26431

Description "CRSP complex subunit, putative"
SequenceMAPIPLEGVQMPVGNGVPQEGNRGGSISLGFLIDLIVQRTYHELSVLAELLPRKTDMERKIEIYNYSARTRQLFVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADILAKMARETLVHARLPNFHIPAAVEVLTTGTYSRLPACIRDRIVPPDPITSSERKNTLERLNQVIQHRLVTGNLLPQMRNLKIDYGRVTFHVENEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHTLQVNYIHQVIQTRLVDNPDPLREVYNCLHFFCQSLQLEVLYSQTLRLCRDRLDDHIHVNDYTPGKCLSVSYWKELSSKDPKSELGYKLTVQVDNYDPARPLTVVHVPSLGGKESEIADKAIRSDILSMERLLVHTIYVRTKARLSELKQELESVLKDIECQLQGSPAILSVPVLQPCLRAENLLVTVDTHTGMLQCHIPQYEAPLIPELQAALNGDRTRLPNLISELRYWITQRRCEKTLQHLPATPYERLPLLHHPDHPMTKIGRHRMYVRLHRHPNAILIVEFKEKENAPYEIDCQFYMAVVKQSSIEDNPEDDTIETEIPKMYLKVLSLIEFDSFVILHGPYTSIEDEKVPGKRKASGKFESSPRRLKQPAYFIPELAHVVSLCDERIPFVTLAQELTKHGIPHQGLQVEANATALVLRIIQLPLPTTKVKKSSWQALLRRLLSVSIRVHGKGTGRSWMVEFVFYGSPLNSSQPKEQGLRRPVYFQYDMGSSDMPVRTVESLLNDWAQIVNLYDCVEELTEYLKISKYNLSQIMTIKSYSYSKLVIGYGPDRGALVTVQWNEHNKAFYLIFGANNQTPNAHSLIKEQLEAHLNRHRNLAQIIHLLHETYQPVLSISKLPTLPQLGVHNNRPQIPVQTFTILPQTPTFIRFAYQGTYCLEIRLRGGGMVSLRDGAYSRFDKSNVVEEFTPTQGLKTFLCKYVDETAALRRRSQCEDDDPPSPITMDSDGSGMTFLGSHHRSPHSPAQGREGLKFHPPVTPPSGSNPHTPSSPHTSSMSQSHSQTFGSSPATSFNLASPPSLPATINPSPSMLPHPSPGGLLANSPSNPLHVPSPAGLLPISSPGPVQVGHSPAGSFMGQTNHLDGSPFPSSQGMASPAVSNWPGSPSIPRPSPARPGQSPSASGYAALQSPDHKSGPHISRVLPQRTWAGAVPTLLTHQAFDLLCTPSPHPQGLLGIELSPLERFLGCVYMRRQLQRFIQSDDCLTAINSTEPGVVLFKVETLQCRVALNPQHLQSLHLKVTPLPEHKDQWSVEDLQIIEKFFDNKAAAPPYKPNALCGFGRMLNVPFNVLKDFIQIIKLEMMPNLVQQQQLKWSVQWCLRIPPSATPIVPIGQAAILVCRNKILFFLQVTRVGVQYVNGMEPPSLVLPLVYDVSTNLTQLAEKRDPGPATAMTAASMQLKRFAEFGLNHNECSLFPAVRDLLANLILPSEPQIISSPAHTGSVTPTMQPSPAMGGGPPVVGSQTTGTYTGMALGQHGMMGPN
Length1511
PositionTail
OrganismPediculus humanus subsp. corporis (Body louse)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Psocodea> Phthiraptera> Anoplura> Pediculidae> Pediculus.
Aromaticity0.07
Grand average of hydropathy-0.243
Instability index55.99
Isoelectric point8.25
Molecular weight168334.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26431
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     236.17|      72|      76|     139|     210|       1
---------------------------------------------------------------------------
  110-  167 (79.42/46.86)	.................TADILAKMARETLVHARLpNFHIPA.AVEV.LTT.GTYSRLPACIRD.RIVPPDPITSSERK
  168-  242 (112.44/69.59)	NTLE..RLNQVIQHRLVTGNLLPQMRNLKIDYGRV.TFHVEN.EFEVsLTVmGDGPNIPWRLLDiDILVEDKETGDGKA
  245-  285 (44.32/22.70)	HTLQvnYIHQVIQTRLV.DNPDP.LREV...YNCL.HFFCQSlQLEV................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     289.44|      74|      75|     387|     460|       2
---------------------------------------------------------------------------
  319-  382 (59.90/27.97)	........KELSS..KDPKSE..L.GYKLTVQVDNYD.P....ARPLtVVHVPSLGGkeseiadkAIRSDILSMERLLVHTI.....
  387-  460 (123.07/65.15)	KARLSELKQELESVLKDIECQ..LQGSPAILSVPVLQ.PCL.RAENL.LVTVDTHTG........MLQCHIPQYEAPLIPELQAALN
  463-  536 (106.47/55.38)	RTRLPNLISELRYWITQRRCEktLQHLPA...TPYERlPLLhHPDHP.MTKIGRHRM........YVRLH.RHPNAILIVEFKEKEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     315.05|      66|      69|    1027|    1093|       3
---------------------------------------------------------------------------
  967- 1022 (42.94/13.56)	.............................P.PS.PITMDSDGSGMtflgshhrsPHsPAQGreGLKFHPPvtppsgSNP................HTPS........S..P....HT
 1027- 1093 (123.50/56.71)	QSHSQTfGSSPA....TSF.....NL.ASP.PSLPATINPSPSML.........PH.PSPG..GLLANSP......SNPL...............HVPSPAGLLPISS..P....GP
 1098- 1165 (83.64/33.78)	H........SPA....GSFmgqtnHLdGSPfPSSQGMASPAVSNW.........P..GSP...SIPRPSP......ARPG...............QSPSASGYAALQS..PdhksGP
 1172- 1242 (64.97/24.59)	PQRTWA.GAVPTllthQAF.....DL.LCT.PS........................PHPQ..GLLGIEL......S.PLerflgcvymrrqlqrFIQSDDCLTAINSteP....G.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.45|      22|      36|     836|     857|       4
---------------------------------------------------------------------------
  836-  857 (38.29/25.89)	QLEAHLNRHRNLAQIIHLLHET
  872-  893 (40.17/27.58)	QLGVHNNRPQIPVQTFTILPQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.71|      45|      47|    1380|    1426|       5
---------------------------------------------------------------------------
 1380- 1426 (69.55/46.67)	RVGVQYVNGMEpPSLvLPLVYDVSTNLTQLAEKR.DPGPA.TAMTAASM
 1430- 1476 (71.16/39.23)	RFAEFGLNHNE.CSL.FPAVRDLLANLILPSEPQiISSPAhTGSVTPTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      12|     109|     611|     622|       8
---------------------------------------------------------------------------
  611-  622 (23.68/13.50)	SSPRR..LKQPAYF
  721-  734 (18.97/ 9.20)	SQPKEqgLRRPVYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.58|      21|      21|     664|     684|       9
---------------------------------------------------------------------------
  664-  684 (35.13/22.39)	ALVLRIIQLPLPT.TKVKKSSW
  686-  707 (30.45/18.38)	ALLRRLLSVSIRVhGKGTGRSW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26431 with Med14 domain of Kingdom Metazoa
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