<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26413

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEAPGPLRGAQPSVELQKLFADIFDNVLSDFIKLSQPDSVGQADRESADQRKYRLLQHLNGTRQQLLRAVALLNWKPWKVLNELVDHDRVLDVAASHVRTMTEVVQQMRQQAAGRIMAGSYLNMYDVNTALEVLTTGTYQELPSIILQRPPLFQPPPASPARQRSRLAHVTHLIRARLVQVALPPGLKVASVSHGTAVLQAEGLYEAKLTLVPSEPLLGVDAAPDAAAGGGGEAGGSGGGAGYDWTAAGAAAAAADPLAAAAASQRWKWRLIHFVLAIGVPFYDPRQPGQILNTCNFHMVLAADNAAYLRRQRQGAGGVAAAGGGPTASTMSESTATPAASGLQLPGAAAAGGGTLAAAVRRSEDDEVGAPLAVMHAILTDVAGRLLVDELAAAARALAAPGSRWHGHISVKPSQLLHPGVRIEYWTQAPQLVSNRALPPACPGEDWRSAKLGPPYLELGMGEGGCVEVLNSPSSLHKPMSLSKLRRLDTFRVNVEEVLMRAANMTSQFQLMQLTPHFLAYDFPIPARVSLLPFTFLPTHAGTTPSASGVDPQIRHELKVILMEAKRAPTLRLSSIARQLWCRDGHVPHQQSGGTQEDEPQADGQPQSQTRDGGEAAGALSTAGEVAGSAVPMDLDPAPDTSGAAAVGGGDSGGATAPPPPPRILPPTAPPPEVSGLLARAAPEEEVAGALVVLSAPVLEYLVSGTTELKIGKHLFSGRLTLRPGQDERDEGSLDHAATIAMNEDYVNQAAMAAYNSASADSCPAWRALKEACVALCHVLQRTHTSTDATHFIQAARRAALHISRLPHGMLEAFTATTPGLAIEPRPREKVATWALQCVPFPPNFPSLEPVAPDTLPLRMPQCLTFFLQSRLSLTSPHVLVVCSCNKQLMPIKVWQANASPPHQRTRVGFASPRHSTALHDRAKKYITWHDMAAYGTVLSCIPVPASTYRLPDHVVAAYMAASTAAHGGGSGGSGGGHGTVNDNGLHSPHSGGNSPRAAANGHEVGGGHSPEASPWRGSSGGTGVGVLQVRSTAGGGGGGGGGGAPSSAPSGAGQGSDAVATATGQTSGVPSLPAAASPPYAHSSYSHTQGRIPSTGAAANAVHASCGGGVRAAVGSKPGGASGRPTGQQVAVMIAQQQLSSVVRWCRRRMVWEVLLVQLKAVGATFVELCNPPCQRVRVTAVAGTALPCHMVRRRGLTPPRVGPTCLELELGPDPLAGQVTARLYGRFLCSPGCAPLDRNTAAAAGGPGARAFASATAGFVLDEQGALAGGATHNGSSASGDPGLVCLRRQYCLERGESALTLVQEVSAIIRMQTLLARLEMTTRPVATTSAAGRGGVRVQRLAVLTPPTAATDPAAVDADGQGRPLQPKTPLHSQQLQQPIGGTCSFRPGSVDAAGPGEYGAGAAASSSSYHPLQPAAKRIKTEPGAAAPAPGADLAYGDGRWSSWQQQQPQPQKQLQQQQQPGLAGYVPPGAGLLPANGVMDGHAMGVGQVPGRPGSCAPGAASSGGANGGGGSASGVTGTASSGLTWHWPLVGTLTLEDYSCSAATLRVTPCTTGPRQGSAPAAADAGHNAVMPPPPLLLHMTWAPRDVRDPYGGTGGAGGGTAAAAGGGATPGTSTPAPTPGGIIALPPSQPSPSPAILGGVAASPLTAATPPQPYPSGLLPPVDAGVRTTRLGPPRSPGEPFGSQFCDLVLCTISCSSGHSLPPEYLQVLEELAEAGEEGKLLDAVAVAAWPVAGFCASLRPPVLSRYGLLPDMDVRLTMQQPPFCLRIVCRKRGSGGGSSNNVLIIDLICLALGRSFLRQQQQQQQQQQQQGLGALEAAAGGAPERQSMTGGPSVKAESGATSGGAAAADAASTSQAILASVQQQVRERLGDRVHDCVQQAVEIVYGALG
Length1897
PositionTail
OrganismVolvox carteri f. nagariensis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Chlorophyceae> CS clade> Chlamydomonadales> Volvocaceae> Volvox.
Aromaticity0.04
Grand average of hydropathy-0.126
Instability index53.08
Isoelectric point8.33
Molecular weight195115.63
Publications
PubMed=20616280

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26413
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.23|      28|      28|    1239|    1266|       1
---------------------------------------------------------------------------
  226-  251 (34.61/ 8.00)	AAAGGGGEAGGSGGG...A.....GY..............dwtaaGAA
  321-  348 (30.88/ 6.28)	AAGGGPTASTMSEST...AtpaasGLQLP.................GA
  966-  998 (33.30/ 7.39)	AHGGGSGGSGGGHGTvndN.....GLHSPHS.....ggNS.....PRA
 1244- 1278 (37.44/ 9.30)	AAAGGPGARAFASAT...A.....GFVLDEQgalaggaTH.....NGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.08|      26|      27|    1465|    1490|       2
---------------------------------------------------------------------------
 1002- 1021 (31.71/ 6.48)	GHEVG..................GG.....HSPEASPWRGSSG
 1036- 1055 (31.78/ 6.51)	G...G.................GGGGGGGAPS..SAPS.GAGQ
 1443- 1485 (31.59/ 6.42)	GRWSSwqqqqpqpqkqlqqqqqPGLAGYVPPGAGLLPANGVMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.62|      24|      33|    1609|    1634|       3
---------------------------------------------------------------------------
  637-  666 (35.86/11.49)	PapdtsgaAAVGG.GDSGGA..TAPPP.PPRI..LP
 1399- 1417 (29.08/ 7.57)	P.......GEYGA.GAAASS..SSYHP.......LQ
 1609- 1633 (33.47/14.44)	........AAAGG.GATPGT..STPAPTPGGIiaLP
 1634- 1667 (27.22/ 6.49)	PsqpspspAILGGvAASPLTaaTPPQPYPSGL..LP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.16|      27|      27|     761|     787|       5
---------------------------------------------------------------------------
  741-  760 (21.39/ 8.44)	.......AMNEDYVN...QAAMAAYNSASA
  761-  787 (47.74/28.65)	DSCPAWRALKEACVA...LCHVLQRTHTST
  788-  817 (35.03/18.90)	DATHFIQAARRAALHisrLPHGMLEAFTAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     170.63|      45|      93|    1673|    1736|       6
---------------------------------------------------------------------------
  439-  488 (49.65/12.64)	.......PPACPGEdwrsaKLGPPYlelgmgeggCVEVLN..SPSSLHK..PMSLSKLRRL
 1673- 1719 (81.47/53.52)	VRTTRLGPPRSPGE.....PFGSQF.........CDLVLCTISCSSGHSlpPEYLQVLEEL
 1762- 1786 (39.51/ 9.08)	VRLTMQQPP...............F.........CLRIVCRKRGSGGGS............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.45|      25|      27|    1312|    1337|       7
---------------------------------------------------------------------------
 1289- 1310 (28.73/10.60)	LRRQYCLERGESALTLVQEVSA........
 1312- 1336 (42.95/22.09)	IRMQTLLARLEMTTRPVATTSAA.....GR
 1339- 1364 (28.77/12.68)	VRVQ....RLAVLTPPTAATDPAavdadGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     234.39|      60|     504|     156|     221|       8
---------------------------------------------------------------------------
  156-  216 (97.01/48.61)	PPASPARQRSRLAHVT......HLIRAR.LVqVALPP..GLKVASVSHGTAVL...QAEGLYEAKLTLVPS.EP
  667-  724 (74.23/31.65)	PTAPPPEVSGLLAR....aapeEEVAGA.LV.VLSAP..VLEYL.VSGTTELK...IGKHLFSGRLTLRP....
 1173- 1237 (63.15/27.50)	....PPCQRVRVTAVAgtalpcHMVRRRgLT....PPrvGPTCLELELGPDPLagqVTARLY.GRFLCSPGcAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.89|      42|     504|    1056|    1099|       9
---------------------------------------------------------------------------
 1056- 1098 (73.36/32.16)	GSDAVATATGQTSGVPSlPAAASPP.YAHSSYSHTQGRIP..STGA
 1099- 1125 (40.15/12.44)	AANAVHASCG..GGVRA..AVGSKP.GGAS......GR........
 1568- 1602 (51.39/18.11)	AADA.....GHNAVMP..P....PPlLLHMTWAPRDVRDPygGTGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.55|      16|      87|    1366|    1381|      10
---------------------------------------------------------------------------
 1366- 1381 (31.01/15.65)	RPLQPKTPLHSQQLQQ
 1452- 1464 (27.32/12.91)	QP.QPQKQL..QQQQQ
 1805- 1818 (21.22/ 8.40)	..LRQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.44|      10|      96|     252|     261|      11
---------------------------------------------------------------------------
  252-  261 (18.06/ 7.22)	AAAADPLAAA
  350-  359 (17.38/ 6.59)	AAGGGTLAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.78|      28|      96|     822|     858|      12
---------------------------------------------------------------------------
  822-  854 (46.90/47.17)	AIEPRPReKVATWA........LQCVPFPPNFPSLepvaPD
  918-  953 (47.88/23.52)	ALHDRAK.KYITWHdmaaygtvLSCIPVPASTYRL....PD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.15|      30|     978|     542|     588|      13
---------------------------------------------------------------------------
  497-  526 (52.19/39.50)	EVLMRAANMTSQFQLMQLTPHFLAYDFPIP
  559-  588 (50.96/17.51)	KVILMEAKRAPTLRLSSIARQLWCRDGHVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26413 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AHGGGSGGSGGGHGTVNDNGLHSPHSGGNSPRAAANGHEVGGGHSPEASPWRGSSGGTGVGVLQVRSTAGGGGGGGGGGAPSSAPSGAGQGSDAVATATGQTSGVPSLPAAASPPYAHSSYSHTQGRIPS
2) CRDGHVPHQQSGGTQEDEPQADGQPQSQTRDGGEAAGALSTAGEVAGSAVPMDLDPAPDTSGAAAVGGGDSGGATAPPPPPRILPPTAPPPEVSGLLARAA
3) QQQQGLGALEAAAGGAPERQSMTGGPSVKAESGATSGGAA
4) SPAILGGVAASPLTAATPPQPYPSGLLPPVDAGVRTTRLGPPRSPG
5) TLRVTPCTTGPRQGSAPAAADAGHNAVMPPPPLLLHMTWAPRDVRDPYGGTGGAGGGTAAAAGGGATPGTSTPAPTPGGIIALPPSQP
6) VRVQRLAVLTPPTAATDPAAVDADGQGRPLQPKTPLHSQQLQQPIGGTCSFRPGSVDAAGPGEYGAGAAASSSSYHPLQPAAKRIKTEPGAAAPAPGADLAYGDGRWSSWQQQQPQPQKQLQQQQQPGLAGYVPPGAGLLPANGVMDGHAMGVGQVPGRPGSCAPGAASSGGANGGGGSASGVTGTASS
966
582
1815
1640
1550
1339
1095
682
1854
1685
1637
1527










Molecular Recognition Features






MoRF SequenceStartStop




NANANA