Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MTTSTQPQSPALLRLAHVERKIVQAVEFAGSVMEELANAGGPRMEFATTQCHEFMKSMKDIQTVLHEEIKSMCEYRPYENCDYIPRMGGEISLKKIDCVLDELQKLEDTINNYQSSGPS |
Length | 119 |
Position | Head |
Organism | Selaginella moellendorffii (Spikemoss) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Lycopodiopsida> Selaginellales> Selaginellaceae> Selaginella. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.462 |
Instability index | 38.36 |
Isoelectric point | 5.01 |
Molecular weight | 13459.23 |
Publications | PubMed=21551031 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP26402 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 36.81| 10| 16| 27| 36| 1 --------------------------------------------------------------------------- 27- 36 (17.16/11.39) EFAGSVMEEL 45- 54 (19.65/13.86) EFATTQCHEF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ALLRLAHVERKIVQ 2) LHEEIKSMCEYRPYENCDYIPRMGGEISLKKIDCVLDELQKLEDTINNYQ | 11 65 | 24 114 |
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