<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26365

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMALQQLGQETVPLSVLVKRAAEAAYTGLKEVCEAAPEQSDAEKKISLLKFILKTRQRLLRLLVICKWCRQIPLVERCQQLMGTLSNHDMSFTQAADSMFYLHESLQQSRAPMYDVASAMDVLFTGGFPRMPKCIEDLNVQPVLEGWKKDNVLQKLDTLLRSKLLDIAIPKEFTSVSVRDGRLTLRVDGEFEVELTLGYRGNASLWRVLHLKLLVGESSRPAKFSDMQRLALSDDLERRMSALENPFGIIYTVLHEFCAALVMDTLWRQVRALRHGRWKDAIRLDLSFETAASGNPATQAPADAEADPSKSRVHGVKITYWLDLAKGGESLLPSLRIEPGSDQRISCQHQPPLTDPGTGNDAEFVLDQSRLDVEKLILRVINCNIHSRLVEVQKSLKANTYIHRVEDDVDKAYILGVPNGFCVSFPVQDTSDIGEDSLHVRAYGDLYICLSISIRNGRFVLRAPSTLLSLSLVQEMEEAINQGTSVVDVFINLRNQSIIHHYASLGGSMNLKVFEKGAITLKFPEDGPKLGSDVLVLGFPNTGDLYFLAVHLDPAFMPLFVLLEAQKLVPLPNRTTVAAKHLVIRRYMSIDISKFSLAGNDENLSLLSDNVKSGGRSLVPKTAEVRNGFDRMDNQVVKLEKAEQQPNFAMGQLQRYHASPSVSLGSPSSRASFGNHNRKSSSSNNLLALVSQAMGSPARNSFSRMSPSTKLPELEYGRLKSPLLPVDNPASPDLDDDHLSKLIESISTGGPATDNMASTGLRQVHSSPSSRTVKSASKNSLKSLHLVPRKGLPDGLGSPLAKDMDRSPYLLPAPSRQLSSLKRKPESDIFSSLPSLQRLSLGARKKQKVEAPSNALEVFSGQPYAAVVAAANQGKAPPVTHMAVLLHVVKRSWLVIKHARLTNQMDSLGISYVEEGRLSSSAGLIFRLATSRMRGDMGKYCNAWQRISLSLGQHGSDGWEVKVRDSHYKSLWSLQKQKVADWGAGVQLAALSEADAHIKCSQEGLILSYSTVEDDSIKKLLADLERLRSARAFAHCMKKLLEDRMDEGDEGASRTDTKWEAITRAFKVEALGLTSLWFSYTGSMPGILARFVVEWASDQEGCIVHVSPEQLWPHTKYLEDLINGGDVELLLDAIRITAGPLHALAGAIRPARMTAPVSSIVASAISPPGQVSPPNSSATPQSRATGLSIQIPTITSGPGRGPGPGIVPSSLLPTDISVLMRSPYWIRIVYRKQFSVDMRCFEGDQVWLQPAPPPQGAGPDAGGSLPCPQFRPFVMENVLNSSETVVTGVQQNGPASANPRSNASATRNTPSSAASGRNLVIGGPGYPSYRGELNSAFCGVSDDGGYSGAWVPLPALKKVLRSTLKYLGVLWLFAQFPNIIREVLGSVMNGRDGTLLHLDPEQPALRFNIGNCMFAVNMHRHQLYLQGLNVKKFQQPPPELQTDPPGADADLTNGEMLEITEFFAQRVASEPYDASRLASFVTILTLPIAVLREFLGLISWMKEAQKNQAVEATPRPRIELCLENRLVINTTMKEEAGSSTSVKSSILHDREREIVEFALTVFLDLGPHVNVNVAGGAGWLPQCVSVRMRYYYNKGGRRVLLVGLEGSHGGRACWSRGDEWERLKERTKVLEAAAAGQESSGRLRAVAESVQLTLQSALQQLRAV
Length1663
PositionTail
OrganismSelaginella moellendorffii (Spikemoss)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Lycopodiopsida> Selaginellales> Selaginellaceae> Selaginella.
Aromaticity0.06
Grand average of hydropathy-0.196
Instability index46.03
Isoelectric point8.69
Molecular weight182407.77
Publications
PubMed=21551031

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26365
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     300.49|      89|     100|     607|     706|       1
---------------------------------------------------------------------------
  552-  599 (58.11/24.53)	........................................DP...AF.MPLFVLLEAQKLVPL..P.........NRTTVAAKHL....VIRR.....YM.SIDISKFSLAGN
  607-  706 (133.26/92.82)	S.DNVKSggrSLVPKTAEVRNGFDrmDNQVVKL.EK.AEQQP...NFAMGQLQRYHASPSVSLgsPSSRASfgnhNRKSSSSNNL..LALVSQ.....AMGSPARNSFSRMSP
  714-  807 (109.12/54.48)	EyGRLKS...PLLPVDNPASPDLD..DDHLSKLiESiSTGGPatdNMASTGLRQVHSS.......PSSRTV......KSASKNSLksLHLVPRkglpdGLGSPLAKDMDR.SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.14|      17|     951|     523|     539|       2
---------------------------------------------------------------------------
  523-  539 (31.89/21.04)	PEDGPKLGSDVLVLGFP
 1470- 1486 (30.24/19.53)	PYDASRLASFVTILTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.10|      89|     951|     215|     310|       3
---------------------------------------------------------------------------
  215-  310 (139.24/134.59)	GESSRPAKFSDMQRLA..LSDDLERRMSA.LENP.FGIIYTVLHEFCAALVMDT.LWrqVRALrhgrWKDAIRLDL.SFE.TAASGNPAtQAPADAEADPSKS
 1168- 1263 (130.87/102.81)	GQVSPPNSSATPQSRAtgLSIQIPTITSGpGRGPgPGIVPSSLLPTDISVLMRSpYW..IRIV....YRKQFSVDMrCFEgDQVWLQPA.PPPQGAGPDAGGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26365 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGQVSPPNSSATPQSRATGLSIQIPTITSGPGRGPGPGIVP
2) SPARNSFSRMSPSTKLPELEYGRLKSPLLPVDNPASPDLDDDHLSKLIESISTGGPATDNMASTGLRQVHSSPSSRTVKSASKNSLKSLHLVPR
3) SPSVSLGSPSSRASFGNHNRKSSSSNNLLALVSQAM
4) VVTGVQQNGPASANPRSNASATRNTPSSAA
1167
695
658
1284
1207
788
693
1313










Molecular Recognition Features






MoRF SequenceStartStop




NANANA