<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26357

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMALGQETVPLSLLVKRAAEAAYTGLKEVCEAAPEQSDAERKISLLKFILKTRQRLLRLLVICKWCRQIPLVERCQQLMGTLSNHDMSFTQAADSMFYLHESLQQSRAPMYDVASAMDVLFTGGFPRMPKCIEDLNVQPVLEGWKKDNVLQKLDTLLRSKLLDIAVPKEFTSVSVRDGRLTLRVDGEFEVELTLGYRGNASLWRVLHLKLLVGESSRPAKFSDMQRFALSDDLERRMSALENPFGIIYTVLHEFCAALVMDTLWRQVRALRHGRWKDAIRLDLSFETAASGNPATQAPADAEADPSKSRVHGVKITYWLDMAKGGESLLPSLRIEPGSDQRISCQHQPPLTDPGTGNDAEFALDQSRLDVEKLILRVINCNIHSRLVEVQKSLKANTYIHRVEDDVFLKSSAQDTSDIGEDSLHVRAYGDLYICLSISIRNGRFVLRAPSTLLSLSLVQEMEEAINQGTSVVDVFINLRNQSIIHHYTSLGGSMNLKVFEKGAITLKFPEDGPKLGSDVLVLGFPNTGDLYFLAVHLDPAFMPLFVLLEAQKLAPLPNRTTVAAKHLVIRRYMNIDISKFSLAGNDENLSLLSDNVKSGGRSLVPKTAEVRNGFDRIDNQVGKLEKAEQQPNFAMGQLQRYHASPSVSLGSPSSRASFGNHNRKSSSSNNLLALVSQAMGSPARNSFSRMSPSTKLPELEYGRLKSPLLHVDNPASPDLDDDHLSKLIESISTGGPATDNMASTGLRQVHSSPSSRTVKSASKNSLKSLHLVPRKGLPDGLGSPLAKDMDRSPYLLPAPSRQLSSLKRKPESDIFSSLPSLQRLSLGARKKQKVEAPSNALEVFSGQPYAAVVAAANQGKAPPVTHMAVLLHVVKRSWLVIKHARLTNQMDSLGISYVEEGRLSSSAGLIFRLATSRMRGDMGKYCNAWQRISLSLGQHGSDGWEVKVRDSHYKSLWSLQKQKVADWGAGVQLAALSEADAHIKCSQEGLILSYSTVEDDSIKKLLADLERLRSARAFAHCMKKLLEDRMDEGDQGASRTDTKWEAITRAFKVEALGLTSLWFSYTGSMPGILARFVVEWASDQEGCIVHVSPEQLWPHTKYLEDLINGGDVELLLDAIRITAGPLHALAGAIRPARMTAPVSSIVASAISPPGQVSPPNSSATPQSRATGLSIQIPTITSGPGRGPGPGIVPSSLLPTDISVLMRSPYWIRIVYRKQFSVDMRCFEGDQVWLQPAPPPQGAGPDAGGSLPCPQFRPFVMENVLNSSETVVTGVQQNGPASANPRSNASATRNTPSSAASGRNLVIGGPGYPSYRGELNSAFCGVSDDGGYSGAWVPLPALKKVLRSTLKYLGVLWLFAQFPNIIREVLGSVMNGRDGTLLHLDPEQPALRFNIGNCMFAVNMHRHQLYLQGLNVKKFQQPPPELQTDPPGADADLTNGEMLEITEFFAQRVASEPYDASRLASFVTILTLPIAVLREFLGLISWMKEAQKNQAVEATPRPRIELCLENRLVINTTMKEEAGSSTSVKSSILHDREREIVEFALTVFLDLGPHVNVNVAGGAGWLPQCVSVRMRYYYNEGGRRVLLVGLEGSHGGRACWSRGDEWERLKERTKVLEAAAAGQESSGRLRAVAESVQLTLQSALQQLRAV
Length1648
PositionTail
OrganismSelaginella moellendorffii (Spikemoss)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Lycopodiopsida> Selaginellales> Selaginellaceae> Selaginella.
Aromaticity0.06
Grand average of hydropathy-0.213
Instability index45.52
Isoelectric point8.71
Molecular weight180824.75
Publications
PubMed=21551031

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26357
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     191.34|      67|      99|     596|     691|       1
---------------------------------------------------------------------------
  596-  676 (101.01/87.43)	K....SGGRSLVPkTAEVRN..GFDRIDNQVGKL.EK.AEQQP...NFAMGQLQRYHAspsvslgSPSSRASfgnhnrKSSSSNNL..LALVSQ
  694-  773 (90.32/72.67)	KlpelEYGRLKSP.LLHVDNpaSPDLDDDHLSKLiESiSTGGPatdNMASTGLRQVHS.......SPSSRTV......KSASKNSLksLHLVPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.55|      33|      98|     412|     445|       2
---------------------------------------------------------------------------
  412-  445 (51.75/36.51)	QDTSDIGEDSLhVRAY...GDLYICLSISI.RNG...RFVL
  483-  505 (20.06/ 7.07)	............IHHY...TSLGGSMNLKVfEKG...AITL
  509-  546 (42.73/24.50)	EDGPKLGSDVL.VLGFpntGDLYF.LAVHL.DPAfmpLFVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     424.01|     108|     118|    1082|    1193|       3
---------------------------------------------------------------------------
  987- 1074 (96.28/42.63)	.....................E....GL..IlSYSTVE..DDSIKKLLADLERL.........RSARAFAHcMKKLLEDRMDEGDQgASRTDTKWEAITRA..FKVEALGLTSlwFSYTG...SMPGILAR
 1082- 1193 (178.40/95.16)	DQegCIVHVSPeqLWPHTKYLE....DL..I.NGGDVELLLDAIRITAGPLHALAGAI.....RPARMTAP.VSSIVASAISPPGQ.VSPPNSSATPQSRATGLSIQIPTITS..GPGRG...PGPGIVPS
 1199- 1312 (149.34/71.17)	DI..SVLMRSP..YWIRIVYRKqfsvDMrcF.EGDQVWLQPAPPPQGAGP..DAGGSLpcpqfRPFVMENV.LNS.SETVVTGVQQ.NGP..ASANPRSNASA.TRNTPS.SA..ASGRNlviGGPG.YPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.72|      15|      99|     678|     696|       4
---------------------------------------------------------------------------
  678-  693 (24.06/16.69)	MGSPARNSFSRmSPST
  780-  794 (26.66/13.58)	LGSPLAKDMDR.SPYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26357 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGQVSPPNSSATPQSRATGLSIQIPTITSGPGRGPGPGIVP
2) SPARNSFSRMSPSTKLPELEYGRLKSPLLHVDNPASPDLDDDHLSKLIESISTGGPATDNMASTGLRQVHSSPSSRTVKSASKNSLKSLHLVPR
3) SPSVSLGSPSSRASFGNHNRKSSSSNNLLALVSQAM
4) VVTGVQQNGPASANPRSNASATRNTPSSAA
1152
680
643
1269
1192
773
678
1298










Molecular Recognition Features






MoRF SequenceStartStop




NANANA