<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26337

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMASTSKTASSSTAATNTALNSLTTTTPVFPPRISYADELLTSAFDLTRTPCLVWCRYSSYADAIDGAEAVERARLAIPESNAGKGLLESDLTSVRAGSRSRIYVFRLGAKEALREMKTAMAKLSFEGLEACIALDEIYGPTNSSTARIPSKTTRTILSHFFEAIRTRFVDDVVRQATNVKRDVQRFKTGFLFGATVPMARSTKEQQSTEDNWSAGWDAYASARPLTFVHLDIQLDARLRLLINPIFRPTSHRPLPLPTPFHRHSRTSHASHSSLSAGIPITLLPHGTAAHFLAEYTPTDSRALDREFEKGFRGTGVLFHTSISSSPQDHNAHIPSTPYIIGYLAIENRHGEPKGLTFVYPRQLCLLSTDPKRRPLDNPPELPAPLQPSPTLANAIPPALTSQATLAPGLHSAVASAASSAPVSPLPSASTQAAHPHVAASISRNKATQLFKTMVGRPGEPGAVALEVSAYVDAVAKERERERERMRAARTGSGAGKVDASSTSGAQGSTPAMQITTPGASGLTAGAGFAGGHSASASPAAPYPSGASSFYPSPPSTVPATTHIVPGMTPSVVVSPAAMDITAHHTPAALSQPQPPSVPSQPPTASTSVWGSIQDAANNGFVSGSTGFGTNGGGSNGFGSNGSNGTYGYLGSMDFSMFEDVGMDASVETSAPAAVAAPAPSAPSFAAAPTSFDASGSMGTSGSFGTNTSSAFDTSNAFGTSSSSMDMLAFDMDMAFSDADWNFFDKPGTTSSSDNVAQDGPTPMAITSEPTPLAAPITPASNFAMPPPPPAPPPAYATPATPMQHATPLQHATPMQQATPAYSSPAVHFDDAHANISYESHDLMLDMTTPQVLPPSPPQTPGVRVSHSRNGSLTGGGRFDPISFAQSHHNADNKYAGGGKFASGGKGGMLPSPPPEDTPSSEATWYRSVTDPKIGVVKRLNGVKRKYKGPASPRVKRIHSDPQCMTWEAQGIRKVEAGRCPLDKASWEDGDADLDWVREEEPPETEEEEDESDTDHEDLELDAESLQPPDGRLGASNRASRAPSEAPSLPPYLPLGPTLLRTQFRHSLLLPLSSQSSSDMHTNAASGGHQGNTAACAPTPVSPAAIMGAAAEQSKSLEATAQMVAKEVAENGVWGEVWRAGVGSNDEGARDADEDGDPIAPHSSDIAVVRELWSAVGVQSLTLGALCGVEEESAQDHGTADHAMDIDDSADLPTISSTLKPSLAALPPPHLTVAKGNSIVQVLPTALRFWDKLGLGPRAGRKEAVVYVVYEDAATYTTAGAGGQAGSSMEAQVMAFLSQLVGCFKTHHYGALIPGNSINNRPAGLFPVRFDSSIRKQLAHLHAALESSLHDDDTQPPPTTLLLFLTPLHLLSLATPPLRHLAAALLRTFRPAIESGILFPHLLPEHVLASSPAAPSPFASAELARVCADIYERVRQPVARSAARAFFARQRLITRVQAPASAIARPVPKVKVTADAGTGTLPLDAGTLLHVGYQVSASGKWVLCACVDEYGEGWETGVWLVDGEGDNDDGDGDEQEGARGQGAGVGAGAEARVVSRVWEFAVRFASKAAVDWRVAVARLGVMPVREVEAWAHLLEDPPEISPSCTAVFCVQHDAPWAFAALARPRTTSSSPILDPRTGPPSKHTAGQAIAKHAANQVYVDASAAIFALEVRGGGLPLSASQDAAVRGSFVEESARDKEREHSEDLEDDALDLDACGPLPRRTSALVRTTATAGISTLQLHLMHVRWSGAQEGEQKARLRVLEKELHADVTASYHCLAALAAVRGRHRQGVDPLLPLHLAATEAMTRALDRGEDGADVCGGES
Length1821
PositionKinase
OrganismSchizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Schizophyllaceae> Schizophyllum.
Aromaticity0.06
Grand average of hydropathy-0.265
Instability index44.48
Isoelectric point5.68
Molecular weight191662.91
Publications
PubMed=20622885

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26337
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     525.49|      82|      82|     517|     598|       1
---------------------------------------------------------------------------
  329-  393 (60.61/14.20)	..............................HNAHI.PSTPYiigylaienrhgeP.....KGLT.FVYPRQ.LCLL..STD..P..KRRP...............LD.N..PP.ELPAP.L.QPS..PTLAN
  396-  446 (43.77/ 8.44)	PPA..LTSQA..TL....A........PGlHSAVA.........................SAAS.SAPVSPlPSASTQAAH..P..HVAASISRN.KA..................................
  457-  513 (37.59/ 6.33)	PGEPGAVALE..VS....AyvdavakeRE.RERERMRAART.............G.....SGAG.KVDASS.TSGAQGST...P..AMQ...........................................
  517-  598 (149.86/44.73)	PGASGLTAGA..GF....A........GG.HSASASPAAPY.............P.....SGAS.SFYPSP.PSTVPATTHIVP..GMTPSVVVS.PA......AMDIT..AH.HTPAA.LSQPQ..PPSVP
  602-  682 (98.69/27.22)	PTASTSVWGSiqDA....A........NN.GFVSGSTGFGT.............N.....GGGS.NGFGSN.GS..NGTYGYLG..SMDFSMF.E.DV......GMDAS..VEtSAPAA.VAAP...APSAP
  700-  787 (74.66/19.01)	SGSFGTNTSS..AFdtsnA........FG.TSSSSMDMLAF.............DmdmafSDADwNFFDKP.GTTSSSDNVAQD..GPTPMAITSePT......PL..A..AP.ITPASnFAMPP..P....
  788-  857 (60.31/14.10)	....................................PPAPP.............P.....AYAT.PATPMQ.HAT.P.LQHATPmqQATPA.YSS.PAvhfddaHANISyeSH.DLMLD.MTTPQvlPPSPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     217.57|      57|     191|     996|    1056|       2
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  996- 1052 (95.84/40.59)	VREEEPPETEEEEDESD.TDHEDLELDAESLQPPDGRLGASN.RASRAPSEAPSLPPYL
 1188- 1246 (81.97/33.16)	VEEESAQDHGTADHAMDiDDSADLPTISSTLKPSLAALPPPHlTVAKGNSIVQVLPTAL
 1690- 1723 (39.75/12.71)	..EESARDKEREHSE....DLEDDALDLDACGPLPRRTSA...................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.28|      65|     338|    1249|    1325|       3
---------------------------------------------------------------------------
 1256- 1325 (107.34/65.29)	PRAGRKEAVVYVVYEDAATYTTAGAGGQAGSSmeaqvMAFLSQLVGCFKTHHYGALIPGNSIN....NRPAGLF
 1597- 1665 (109.94/47.40)	PEISPSCTAVFCVQHDAPWAFAALARPRTTSS.....SPILDPRTGPPSKHTAGQAIAKHAANqvyvDASAAIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.05|      33|    1502|      53|      88|       4
---------------------------------------------------------------------------
   53-   88 (52.57/42.14)	VW...CRYSSYAdAIDGAEAVerARLAI.P..ESNAGKGLLE
 1556- 1594 (48.48/28.10)	VWefaVRFASKA.AVDWRVAV..ARLGVmPvrEVEAWAHLLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.54|      41|     338|    1099|    1142|       5
---------------------------------------------------------------------------
 1099- 1142 (63.70/52.61)	PVSPAAIMGAAAEQS..KSLEATAQMVAKEVAENGVWGEvwrAGVG
 1436- 1478 (63.84/42.66)	PVARSAARAFFARQRliTRVQAPASAIARPVPKVKVTAD...AGTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.75|      52|     390|    1374|    1426|       6
---------------------------------------------------------------------------
 1374- 1426 (87.94/53.97)	TPPLRHLAAaLLRTFRPAIESGILFPHLLPEHVLASSPAAPSPFA.....SAE.LARVC
 1724- 1768 (48.18/23.38)	..........LVRTTATAGIST.LQLHLM..HVRWSGAQEGEQKArlrvlEKE.LHADV
 1769- 1817 (74.63/41.21)	TASYHCLAA..LAAVRGRHRQGVD.P.LLPLH.LAATEAMTRALD.....RGEdGADVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.30|      13|      19|     866|     878|       7
---------------------------------------------------------------------------
  866-  878 (25.00/14.53)	HSRNGSLTGGGRF
  888-  900 (25.30/14.80)	HNADNKYAGGGKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.99|      23|     123|     155|     196|       8
---------------------------------------------------------------------------
  162-  187 (34.86/56.63)	EAIRTRFVDD....VVRQATNVKRdvqRFK
  921-  947 (36.12/10.72)	EATWYRSVTDpkigVVKRLNGVKR...KYK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.77|      26|     753|     193|     235|      11
---------------------------------------------------------------------------
  197-  229 (42.95/52.83)	PMARSTKEQQSTEDNWSAGWdayasarPLTFV.H
  259-  285 (42.82/14.98)	PFHRHSRTSHASHSSLSAGI.......PITLLpH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26337 with Med13 domain of Kingdom Fungi
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