<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26332

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMCTPRNYPSLRRGDRAPCAATDVGRHHHQPMNVNGSMAVADIARPLTVNGKENGYHHQEPAVEDLERMLPDVNEGQVPFGMIVSRVAQQIYAELQEVAETLPGMSDVARKRTLADFVVATKKQVVKLYAIAKWARDAETVQKCLNLVGFLMNQKYEIDSAIGRLHQIHDELNPERLGNHDLLTSLDVLTTGTYQRLPTIIKKSVIPVKPLTNPDVVSTFREVEQVMRYRLRTTEYIPIEMMQYRIAGGRVYFTVPNLFEVGVCLVGAQKDDGWFTTHFEFLIGIGGDATEVQEIPRIPTGITKAHLTLEGDRLLGLYTKISEEQIASGVPPNPNVLEEGTADAPLVRLYNFIQIMSLSYQLEILLFQAQRLQYLGWQQYMSCRMSPDRKTLSVRYWLRPRHPRNLVPPSAGTLHISIIDRRTPKGEPFRSPKARKLAEIQRKSKLGDLRPSEEVETLALEARWEPEQDALGVSLPREYVTMREGELVVDPQDLDIERLLRKCISRHTYAILSALQEQLQKGPAADIFGAPGMVTLVEESPGGASLSHDHGTTTPAHPTTITHFDSATHSHPFGPSHPSALAPKDPDTVLALRVCLCAEEVAVISIDPRTGQITIRDTGDLAAPDKGLCFAGPNRGLRFLVITERVNADPVMLFTALMKLRLMTIMEITEQKANYLGLQVYRNRNFEKGELNKLGPNWHGGLFIPLGNVPHHYLVLVMRHNDFDYALITTEDKPDSLFYGMNIIDVAWLDVNRICAGENLQMTGVGGFNINIRCLKALYNYCSARITYMTVEKQFKERHIQFKHVTVASDTHPPALTATQSILARSIPALCVESQHILSGAPAAEAAMPNIRVIPLNWWSDTRAPRVVTCVKLKYVQQPLGRRAGGTSAVIRPSKRIIYDTTHAVVSFLSEDVSKCVDEFLEEWARVSKMVVIAREVAGMSKEKNWPDVRLLSFDLQTVEFAYASDYTVSIYYQDQLTLAGGTFYLRFSREKTDSAMDDDRFNPHADAEPFMRNILQRGHGKLAPSLVRLVTLLRDTLPIVQELEEIMWQSEQKGGMAASVDTFAKAAGWYRLLYGDLRHALDFRLMSGRRVAILDGAVSLFESELPSSAPATEAEIGLVRIPQLCEMIDQVVSEISAADAKKAGSLVMVDKGIVCGVDDLGPADESPCFSHAARSVALSSGDSGGYWSFTRFKKSSTGMKWVFWVFGFPTVTYGTNPAWNGHRRILRHGGAPDRALSPRLALGNDARGCEGVERDIPHVQWELLADDSIDEQAHALHDLGQRHQGDSRVVHQLDEVLVRDASPYQDEPMDAKFGLTLRVNDRAQAGEREGSVPGKIYNLQWLVLGQDGEELLASDYGYGIIREGSSDAANRLHSILISITLRQNLGDGIDVVGCDSLRDGRIDGLSDATGGNRSPLALQAKPPLWLAGSQARHQPATQTPPDNALRLGTAGACPN
Length1455
PositionTail
OrganismSchizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Schizophyllaceae> Schizophyllum.
Aromaticity0.07
Grand average of hydropathy-0.242
Instability index42.46
Isoelectric point6.16
Molecular weight161569.54
Publications
PubMed=20622885

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26332
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.09|      65|    1108|     129|     343|       1
---------------------------------------------------------------------------
  129-  197 (104.34/255.70)	AIAKWARDAETVQKCLNLVGFLMNQKYEIDSaigRLHQIHDeLNPERLGNHDLLTSLD.VLT..TGTYQRLP
 1241- 1308 (106.74/21.57)	ALGNDARGCEGVERDIPHVQWELLADDSIDE...QAHALHD.LGQRHQGDSRVVHQLDeVLVrdASPYQDEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     496.82|     165|     535|     448|     634|       2
---------------------------------------------------------------------------
  448-  634 (253.29/216.68)	LRPSEEVETLALE.ARWEPEQDAlgVSLPREYVTMREGELvvDPQDLDIERLLRKC..ISRHTYAIlsaLQEQLQKGPAA...DIFG.APGMVTLVEespGGasLSH..D....HGTTTPAHPTTITHFDSathshpfgpSHPSALAPKDPDTVLALRVCLCA......EEVAVISIdPRTGQITIRDTG......DLAAPDKGLCFAGPNR
  985- 1174 (243.54/156.56)	LRFSREKTDSAMDdDRFNPHADA..EPFMRNILQRGHGKL..APSLVRLVTLLRDTlpIVQELEEI...MWQSEQKGGMAasvDTFAkAAGWYRLLY...GD..LRHalDfrlmSGRRVAILDGAVSLFES.........ELPSSAPATEAEIGLVRIPQLCEmidqvvSEISAADA.KKAGSLVMVDKGivcgvdDLGPADESPCFSHAAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.32|      59|    1107|     284|     343|       3
---------------------------------------------------------------------------
  284-  343 (96.45/66.01)	IGGDATEVQEIPRI..PTGITKAHLTLEGDRLLGLYTKISEEQIASGVPPNpNVLEEGTADA
 1392- 1452 (98.86/62.90)	VGCDSLRDGRIDGLsdATGGNRSPLALQAKPPLWLAGSQARHQPATQTPPD.NALRLGTAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.10|      28|     309|     351|     379|       4
---------------------------------------------------------------------------
  351-  379 (46.59/38.20)	FIQIMSLSYqLEILLFQAQRLQYLGWQQY
  653-  680 (48.51/34.46)	FTALMKLRL.MTIMEITEQKANYLGLQVY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26332 with Med14 domain of Kingdom Fungi
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