<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26330
Description |
Mediator of RNA polymerase II transcription subunit 14 (Fragment) |
Sequence | MNFNGSMAVADIARPLTMNGKESGMNGNGYHHEEPAVEDLERMLPDVNEGQVPFGMIVSRVAQQIYAELQEVAETLPGMSDVARKRTLADFVVATKKQVVKLYAIAKWAREAETVQKCLNLVGFLMNQKYEIDSAIGRLHQIHDELNPERLGNHDLLTSLDVLTTGTYQRLPTIIKKSVIPVKPLTNPEVVSTFRELEQVMRYRLRTTEYIPVEMMQCRIAGGRVYFTVPNLVGAQKDDGWFTTHFEFLIGIGIGGDATEGRGGEGRGGGRRCRIERKGAGRVARPPAAGAGRV |
Length | 294 |
Position | Tail |
Organism | Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Agaricomycetidae> Agaricales> Schizophyllaceae> Schizophyllum.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.295 |
Instability index | 28.21 |
Isoelectric point | 8.38 |
Molecular weight | 32537.99 |
Publications | PubMed=20622885
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26330
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 62.12| 19| 55| 217| 237| 1
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217- 237 (30.78/28.44) QCRI...AGGRVyfTVPNLVGAQK
272- 293 (31.33/20.37) RCRIerkGAGRV..ARPPAAGAGR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.30| 18| 29| 8| 25| 2
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8- 25 (32.46/16.65) AVADIAR..PLTMNGK.ESGM
36- 56 (24.84/11.49) AVEDLERmlPDVNEGQvPFGM
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|