<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26233

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVGRTAEESFLSLKELVEKSKSTELSDNEKKVSLLKYVAKTQQRMLRLNALAKWCKQVPLINYFQDLGSTLSAHDICFTQAADSLFFMHEGLQQARAPVYDVPSAVEILLTGSYQRLPKCLDDVGMQSSLDEHQQKPALRKLEVLVRSKLLEITLPKEITEVKISKGTVTFSVDGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGPIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRALLQGRWKDAIRFDLISDTGTTPANQEGEADSVSLRTPGVKLMYWSDSDKNSGPFIKIEPGSDLQIKCSHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLKAICCNRYTRLLEIQKELLRNARICRAPSDVILQALLDEPGIEGGNMVDSKERVEPEVLRVRAYGSSFFTLGINIRTGRFLLQSSKSILTSSILEEFEDALNQGSISAVDAFINLRSKGILHFFAAIGKFLGLEVYEHGFGINKVPKSLLDGSSILTLGFPDCESSHLLLMELEKDFTPLFKLVETRMDGSGKPQSFNDPSNILRAKKIDIGQIRILEDDLNLNTSDVVKFVSSSSDAEGINQVSGHRHPGLVDDALTEMSGSQLSFSSIVDEVFGLQKERSALVSSDGHGLVPKNLSAVNGPGKAPMLTSYHSDSLYNLQGPLQSSSYNMLSSPPGMGSAMKKIAISNSDQELSMILSPSLSAGNGVSESGSRMVTESSLSALPLSQTADLATTSVGPLLRKDQKPRKRSASDLLRLIPSLQGMEGVASPIKRRKTSELVQSELVKSWSPASQTLSTVATSTKTIGCSYGNLIAEANKGNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYVEEMGLRDAFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFMDLWELQKGSKTTPWGSGVHIANSSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFSLGMRKLLGIKPDEKTEECSANSTIKGSAGGKGSGETVDRWKAFKIEAVGLTSLWFSFGSGVLARFVVEWESGKDGCTMHVSPDQLWPHTKFLEDFINGAEVESLLDCIRLTAGPLHALAAATRPARASTATGMPVVPAAASSRQSNQIQQTQGIVAPSTLAAPNATGQSVSATSGNTVASSAPSPLGGSFHGVAMLAAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGATNPNSGNPTVNGGNRVNFSPSSAMSRAAMNRVASVASGSLVVSPGLSVRRTPGTAVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQQQQNGSSAAAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQSQQAGEIAPAQRPRIELCLENHSGTDLDNNCAAKSNIHYDRPHNTVDFALTVVLDPVHIPHINAAGGAAWLPYCVSVRLRYTFGESPSVTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSAAGDLTQGKLKLVADSVQRTLHLCLQGLREGNSSNTLQKEFTI
Length1702
PositionTail
OrganismArabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.06
Grand average of hydropathy-0.119
Instability index45.19
Isoelectric point6.88
Molecular weight185189.32
Publications
PubMed=21478890

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
plasmodesma	GO:0009506	IEA:EnsemblPlants

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
cold acclimation	GO:0009631	IEA:EnsemblPlants
positive regulation of cell population proliferation	GO:0008284	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
systemic acquired resistance	GO:0009627	IEA:EnsemblPlants









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26233
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     544.88|     168|     549|     501|     676|       1
---------------------------------------------------------------------------
  430-  594 (217.93/135.68)	...VRAYGSSFFTLGI.NIRTG.RF..LLQSSKSILTSSILeEFEDALNQ..GSISAVDAFINLRSK.GIL.HFFAAI...GKFLGLEVYeHGFGINKVpKSLLDGSSILTLGFPDCESSHLLLMELEKDFTPLFKLVETRMD.GSGKPQSfndPSNILRAKKIDIGQIRILEDdlnLNT
  595-  763 (267.93/144.04)	SDVVKFVSSSSDAEGI.NQVSGHRHPGLVDDALTEMSGSQL.SFSSIVDEVFGLQKERSALVSSDGH.GLVPKNLSAVNGPGKAPMLTSY.HSDSLYNL.QGPLQSSSYNMLSSPPGMGSAMKKIAISNSDQELSMILSPSLSaGNGVSES...GSRMVTESSLSALPLSQTAD...LAT
  782-  852 (59.03/24.08)	SDLLRLIPSLQGMEGVaSPIKRRKTSELVQ..............SELVKSWSPASQTLSTVATSTKTiGCSYGNLIAEANKGNAP...............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.02|      10|     771|     914|     923|       2
---------------------------------------------------------------------------
  914-  923 (21.49/13.25)	HICLQLGRPG
 1681- 1690 (20.53/12.29)	HLCLQGLREG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.94|      63|     168|    1161|    1229|       3
---------------------------------------------------------------------------
 1161- 1229 (99.98/70.93)	STLAAPnatGQSVSATSGNTVASSAPSPLGGSFHGvamLAAAGRSGPGIVPSSLLPIDVSVVLR..GPYWI
 1336- 1400 (105.96/61.23)	SLVVSP...GLSVRRTPGTAVPAHVRGELNTAIIG...LGDDGGYGGGWVPLVALKKVLRGILKylGVLWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.03|      19|     545|     410|     428|       6
---------------------------------------------------------------------------
  410-  428 (34.88/22.19)	GIEGGNM..VDSKERVEPE..VL
  954-  976 (26.15/14.81)	GVHIANSsdVDSHIRYDPEgvVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.69|      68|     175|    1067|    1146|       7
---------------------------------------------------------------------------
 1067- 1146 (101.52/95.53)	RFVVE.........W....ESGKDGCTMHVS.P.DQLWPhtkFLEDFInGAEVESLLDCIrltAGPLHalaaATRPARA.sTATGMPVV...PAAASSR
 1236- 1323 (95.17/59.00)	RFAVDmrcfagdqvWlqpaTPPKGGASIGGSlPcPQFRP...FIMEHV.AQELNGLEPNL...TGSQG....ATNPNSGnpTVNGGNRVnfsPSSAMSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.06|      21|     597|    1027|    1047|       9
---------------------------------------------------------------------------
 1027- 1047 (38.54/24.23)	IKGSAGGKGSGETVDRWKAFK
 1627- 1647 (44.51/29.28)	MEGSHGGRACWQRVDDWEKCK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26233 with Med14 domain of Kingdom Viridiplantae
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