<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26205

Description Uncharacterized protein
SequenceMSATLHMIIMALTATPGSCAMEVDKDAVSAMQESVDQLALSMFDSLRLIPFSEEVKGGARGVAPLQQQQPGQPDAAPLRRAVTTNAAWADTVQSLADGVLKQARALDGLIDVLPGAELREDQQMEEIARLDREGKLKRTELAKMVEKAEALSKGVNGSLDQLADHMLGAPR
Length171
PositionMiddle
OrganismEctocarpus siliculosus (Brown alga) (Conferva siliculosa)
KingdomPhaeophyceae
LineageEukaryota> Sar> Stramenopiles> Ochrophyta> PX clade> Phaeophyceae> Ectocarpales> Ectocarpaceae> Ectocarpus.
Aromaticity0.02
Grand average of hydropathy-0.186
Instability index42.25
Isoelectric point4.86
Molecular weight18304.78
Publications
PubMed=20520714

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26205
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     208.66|      54|      55|      58|     111|       1
---------------------------------------------------------------------------
   16-   53 (50.36/25.03)	............PGSCA.MEVDKDAV...SAMQESVDQLALSMFDSLR.LIPFSE
   58-  111 (88.93/48.71)	GARGVAPLQQQQPGQPD.AAPLRRAVTTNAAWADTVQSLADGVLKQARALDGLID
  115-  164 (69.38/36.71)	GAELREDQQMEEIARLDrEGKLKR..TELAKMVEKAEALSKGV...NGSLDQLAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26205 with Med21 domain of Kingdom Phaeophyceae
Unable to open file!