<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26203

Description Mediator of RNA polymerase II transcription subunit 14-like Protein
SequenceMAPVPLEGIQTLVANAAAQGGLGGPQEGNRGGMISLAKLIDYIIQRTYHELTVLAELLPRKTDMERKVEIYNFATRTRQLFVRLLALVKWANSASKVEKSARIMGFLDKQSLLFVETADMLSRIARDTLVQARLPNFHIPAAVEVLTTGTYGRLPACIREKIVPPDPITSTEKRNTLLRLNQVIQHRLVTGNLLPQMRNLKIENGRVTFHVQHEFEVSLTVMGDGPNIPWRLLEIDVLVEDKETGDGKALVHSLQIQYIHQLIQTRLVDNPQPLTEVYNCLHFFCQSLQLEVLYSQTLRLMRDRLDDHIHVDEYIPGKCLTVSYWRELTTKGKESANKDLRSELGYRLTIQVDAHDPARPLAVLHVPSLGNKESEIADRAIRSEILSMERLLVHTIYVRTRSRLSDIKLEIQGMVKEVECNLQGSPAILSIAILQPCLRAEQLLITVDTHTGMLQCHVPQYDPPLVPELNNALNGDHSKLPVLISELRFWITQRRCEKTLQHLPATAHERLPLLHHSDHPLTKIGRHRMYIQLHRHPNVVLIVELKEKETSMCEVDCAFHMAVVKPSSIEDNPDDDTIETEIPKVYLKVQTLIEFDTFVATHGPFTSIDSDSDHTELNSLKRKGGVKPEPPTRRSKQPAYFISELAHVVAMCDERLPYVSLANELNKRSIFHQGLQVEANATGLVLKLIQLPPPTTEIGGSPAWHALLKRLLTVSIRVLSKGMMKSWMTEFVFYATPLTSTHPKEQGSRRPVYFQYDMATIDATSRTVDSLLSDWYQIVHLYTIVHDLSEYLKGDKYNLSNMFSIKSYNYSKLVLCYGPEKGAMVSIHWNSGEKAFKLAFGATNNAINAHSLIREQLESHLNEYRNLAQIIQLLHETYEPLISISKLPTLPQLGIQNTRPQVPVQTFTIMAQSCTLIRLAYQGMYCLELRIRGAGLVSLRDGAYSRFDRSNVVDVFSPTQGLKAFLSKYVDETAVFRRRSQSEDDNPPSPVSMETHTSFGSSPATSFNLSSPTSLPANINPSPMPHPSPSGLVANSPLNPQLPSPGGLLSNSSPGPVSTSLPGHSPVSSFMATGHTDGSPFPSSQSMASPAASNWPGSPSMPRPSPARPGQSPGGHPIMHSPQSGDMRTGSHLSRVLPQRSWAGAVPTLLTHEALETLCCPSMHPQGLPGPELAPLERFLGCVYMRRQLQRFIHNENYLTAIPNTELGVIHFKVTEILQCRIGLNPQHLQSLHLKITPLPDHKDVWTSEELQVLEKFFDTRAAAPPYKPTAMFTFCTMLNVPVNVLKDFIQIMKLELMPGLVQQQGMKWSVQWMLRIPPSAMPIVPTGMSGVLVYRAKILFFLQITRIGVQYPPNMEPPSLVLPFIYDVNSNMTQLAEKREAGTVPGMAAASQLLKHFAQFQSNISECSIFPALRELLLNLVLPTEPQQSPAPQIQSPAMQMQQGGQPGYPVSMPMGMMGPQ
Length1462
PositionTail
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.07
Grand average of hydropathy-0.196
Instability index55.85
Isoelectric point7.98
Molecular weight163393.78
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26203
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.64|      28|      74|    1018|    1045|       1
---------------------------------------------------------------------------
  988- 1012 (28.80/ 8.94)	...PSP....VSMETH.TSF.GSSPAT.SfNLSSP
 1018- 1045 (56.57/24.59)	NINPSP....MPHPSP.SGLVANSPLN.P.QLPSP
 1051- 1084 (34.27/12.02)	NSSPGPvstsLPGHSPvSSFMATGHTDgS.PFPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.96|      57|      73|     137|     209|       2
---------------------------------------------------------------------------
  137-  196 (96.46/88.69)	FHIPAAVEV.LTT.GTYGRLPACIRE.KIVPPDPITSTEKR..NTL..LRLNQVIQHRLVTGnllPQ
  209-  272 (80.51/46.84)	FHVQHEFEVsLTVmGDGPNIPWRLLEiDVLVEDKETGDGKAlvHSLqiQYIHQLIQTRLVDN...PQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.11|      17|     350|    1089|    1123|       3
---------------------------------------------------------------------------
 1089- 1106 (33.96/18.57)	SPAASnWPGS...............PSM.PR..PSP
 1137- 1171 (19.15/ 7.14)	LPQRS.WAGAvptllthealetlccPSMhPQglPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.63|      37|      38|     308|     344|       4
---------------------------------------------------------------------------
  301-  339 (61.68/37.55)	MRDRLddH..IHVDEYIPGKCLTVSYWRELTTKGKESANKD
  340-  380 (52.95/31.16)	LRSELgyRltIQVDAHDPARPLAVLHVPSLGNKESEIADRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.47|      17|      20|     802|     818|       5
---------------------------------------------------------------------------
  802-  818 (31.84/21.89)	MFSIKSYNYSK.LVLCYG
  824-  841 (27.64/18.06)	MVSIHWNSGEKaFKLAFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.00|       9|      18|     916|     925|       8
---------------------------------------------------------------------------
  916-  925 (12.20/11.48)	LIRLAyQGMY
  936-  944 (15.80/ 8.19)	LVSLR.DGAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.26|      35|     175|     663|     697|       9
---------------------------------------------------------------------------
  663-  697 (58.24/43.42)	NELNKRSIFHQGLQVEANATGLVLKLIQLPPPTTE
  845-  879 (58.02/43.23)	NAINAHSLIREQLESHLNEYRNLAQIIQLLHETYE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26203 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPVSMETHTSFGSSPATSF
2) LSSPTSLPANINPSPMPHPSPSGLVANSPLNPQLPSPGGLLSNSSPGPVSTSLPGHSPVSSFMATGHTDGSPFPSSQSMASPAASNWPGSPSMPRPSPARPGQSPGGHPIMHSPQSGDMRTGSHLSRVLP
3) QSPAPQIQSPAMQMQQGGQPGYPVSMPMGMM
976
1009
1429
1007
1138
1459










Molecular Recognition Features






MoRF SequenceStartStop




NANANA