<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26199

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMNRVTNGNLAMPPSVVDKSKDWQLEILMEKLRSKASQYKSLTEISKNVRMAMLDKRYALDSVEKSQHQKCLDTLQHSIKVTSLQSMIERLESLTRQLGLKFMVGPSGVELFISSDMFYLEIVLDQTGAVKDVKVHHDSKLEQQSCAELVNCLSSGDFADFTAQLEGFASIYQLNAEKKVKCKAFTALQSLESDLSTLAHLQSFMKEPFNLLYKSPVGVLEKRRGGHPMKLTYFVSPYDLLNVEKCDIEPITVDTIVSKALGYSVTVCMEGSATHKLQTTTLITVNRNINGKSTPSFSSLSSQNSAAIPACFVLKLNKPMPMCVNLVRQIQQVTELDTIEQSATHPLLSLIVHHASEGKMESGNNKGLFVTLPDQTHCYFMTENKNMDGVLVSSIPFTHPAHVSQILVILRQQALFNTIIGSCVRPNSKQDFENMTMFEISALSWTHISLSLEHPIEESMATAEIDLSDISNLVCKIVSPGTPPPPNAPDTASDLSTKILNRCFSIPVTMRAVLKLWEKQTTKRHYNGHENFSLPLGSGDPGGHKGAPGGNLTEFGGLDKIKQEPLGNGSHGMMMQSHQGMFLNESMIASANFPNFQTSENMLTSMELTNILAGANQSDKMKRPHKRKSDDLWKNKRKLGEGADPDLLVETSSSDSTSRSTPISQENEIATPNSGLGFQSDLELMSGLDPADLLAESDKVGGDFGALDELGDVEEMLAGPSRRKSHDQKSPTIMMDLGEKSLVPPSVSITPIASTSPGFNQGGNAEKRPGIEIIALATSAATALPSSITITPITTSQSKGDEKNREKKRSKSSSDDKGRLEKKRKRKRDESPMGPPDKVPPKQDPLTKPVTVSIKPAESPPLNMSTPTSPSMMRKFNASPTQNRNISMSGKLSPNLMKPTLKTGSSHHSPKHSPAHVPSSPKHIIPGISSPKSHGTSPKHPSTSGSGKPSMSTLKSAANSPKNSDSKTKSTSKDSSRDKEKKISGVFNVASKNKSSVKVKPLDLNTENLSGVQDGLPSPSSTDLSKSATSNQVRNRKGSLSAIVDKLKSAQHCDGVTDLSSKGASSGGNKDRSGQVSTKLNEGKSGKIGETKNSEYMVKPSSDGMKITINKTRSKESKTSVSKSGSGSPKTHTGLKPGVNSGPASKKPQHLGQKLVNSTSGPNYSSLKSKAPSGAKLSSGPSKLTKLSNSPKSATDLSRKDRPKLNKSSSEKSIFTSKDGRKSSPTSNRDESDGIYKMSKMDHYNPPSIVEGLMTVRQLDKNFQIPKLSARASVDDKKPKVSSDNLNNINRTVDTKIFDMMNKSDLKYPLALPQKTFDNAVDVKLRNNVTPLPSSSPKLKDEDDKKDQPQNLAQTKDDSAYKVNYPIAVSKSVLPPISEPLNLYTKSIDLTSKFVAPAPKDDKKDVKKNDDVLLDFSAAGKIDKGAAVVTFPQSPSVSVHIVKSPAPSPLIAPSPHSASPCITDDELMDEAVIGIGK
Length1476
PositionMiddle
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.04
Grand average of hydropathy-0.574
Instability index50.21
Isoelectric point9.29
Molecular weight159710.71
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26199
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1091.55|     269|     275|     734|    1008|       1
---------------------------------------------------------------------------
  478-  711 (273.57/101.18)	...................SPGTPPPPNAPD............TASDLSTKIlnrcfsipvtmrAVL.KLWE.KQT.............TKRHYNGHENFS....................lPLGSGD.PG..GHKGAPGGNL.....TEFGGLDK....I..KQEPLGNGSHGMmmqshqgmflnesmI..ASANFPNFQTSENMLTSMeLTNI.LAGANQSDKMKRPHKrKSDDLWKNKRKLGEG..........ADPDLL..........VETSSSDSTSRSTPISQENEIATPN.SGLGFQSDL..................ELMSGL......DPADLLAESD.......KVGG.............DFG................ALDEL...GD
  736- 1010 (433.16/177.58)	LGEKSlVPPSVSITPIASTSPGFNQGGNAEKRPGiEIIALATSAATALPSSI............TIT.PITT.SQS.............KGDEKNREKKRS.....................KSSSDD.KGRLEKKRKRKRDE.....SPMGPPDK....VPPKQDPLTKPVTVS..............I..KPAESPPLNMSTPTSPSM.MRKF.NASPTQNRNISMSGK.LSPNLMKPTLKTGSSH.....HSPKHSPAHV..........PSSPKHIIPGISSPKSHGTSPKHPStSGSGKPSMS..................TLKSAANSPKNSDSKTKSTSKDSSRDKEKKISG.............VFNVAskNKSSVKVkPLDLNTENL...SG
 1011- 1321 (303.13/113.10)	VQDGL...PSPSSTDL.SKSATSNQVRN...RKG.SLSAIVDKLKSAQHCD.............GVT.DLSSkGAS.............SGGNKDRSGQVStklnegksgkigetknseymvKPSSDGmKITINKTRS.KESK.....TSVSKSGS....GSPKTHTGLKP.GVN..............S..GPASKKPQHLG.........QKLvNSTSGPNYS.SLKSK..APSGAK..LSSGPSKltklsNSPK.SATDLsrkdrpklnkSSSEKSIFTSKDGRKSSPTSNRDES...DGIYKMSkmdhynppsiveglmtvrQLDKNFQIPKLS.......ARASVDDKKPKVSSdnlnninrtvdtkIFDMM..NKSDLKY.PLALPQKTFdnaVD
 1322- 1459 (81.69/24.20)	......VKLRNNVTPLPSSSPKLKDEDDKKDQPQ.......NLAQTKDDSAY............KVNyPIAV.SKSvlppiseplnlytKSIDLT.SKFVA.....................PAPKDD......KKDVKKNDDvlldfSAAGKIDKgaavVTFPQSP...SVSVH..............IvkSPAPS.PLIAPSPHS..........ASP.....................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     410.36|     133|     274|      59|     197|       2
---------------------------------------------------------------------------
   59-  197 (204.34/123.83)	LDSVEKSQHQKCLDTLQHSIKVTSLQSMIER..LESLTRQLGLKFMVGPSGVE.LFISSDMFYLEIVLDQTGAVKDVKVHHDSKLeqQSCaelVNCLSSGDFADFTA.QLEGFA.SIYQLNAEKKVKCKAFTALQSLeSDLSTL
  335-  472 (206.02/111.05)	LDTIEQSATHPLLSLIVHHASEGKMESGNNKglFVTLPDQTHCYFMTENKNMDgVLVSSIPFTHPAHVSQILVILRQQALFNTII..GSC...VRPNSKQDFENMTMfEISALSwTHISLSLEHPIEESMATAEIDL.SDISNL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26199 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DVKLRNNVTPLPSSSPKLKDEDDKKDQPQNLAQTKD
2) FGALDELGDVEEMLAGPSRRKSHDQKSPTIMMDLGEKSLVPPSVSITPIASTSPGFNQGGNAEKRPGIEIIALAT
3) LPSSITITPITTSQSKGDEKNREKKRSKSSSDDKGRLEKKRKRKRDESPMGPPDKVPPKQDPLTKPVTVSIKPAESPPLNMSTPTSPSMMRKFNASPTQNRNISMSGKLSPNLMKPTLKTGSSHHSPKHSPAHVPSSPKHIIPGISSPKSHGTSPKHPSTSGSGKPSMSTLKSAANSPKNSDSKTKSTSKDSSRDKEKKISGVFNVASKNKSSVKVKPLDLNTENLSGVQDGLPSPSSTDLSKSATSNQVRNRKGSLSAIVDKLKSAQHCDGVTDLSSKGASSGGNKDRSGQVSTKLNEGKSGKIGETKNSEYMVKPSSDGMKITINKTRSKESKTSVSKSGSGSPKTHTGLKPGVNSGPASKKPQHLGQKLVNSTSGPNYSSLKSKAPSGAKLSSGPSKLTKLSNSPKSATDLSRKDRPKLNKSSSEKSIFTSKDGRKSSPTSNRDESDGIYKMSKMDHY
4) MELTNILAGANQSDKMKRPHKRKSDDLWKNKRKLGEGADPDLLVETSSSDSTSRSTPISQENEIATPNSGLGFQSDL
5) NGHENFSLPLGSGDPGGHKGAPGGNLTEFGGLDKIKQEPLGNGSHGMMMQSHQGM
1321
703
783
605
526
1356
777
1243
681
580










Molecular Recognition Features






MoRF SequenceStartStop




1) EIIAL
2) IYKMSK
3) PTLKT
771
1234
898
775
1239
902