<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26195

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDHIFTINKKINKSVDTSKHLSFTKLEKSTLCSISSSNVVAFSTECNIEEAGSLFWNSNVYVCDLNSPWQVHKILSNSSPISVLQWDFTGDLLLVADENGSIKIYKAKDHILNDWTLVLQTVLEGEHILSAAFFHSGKKICLNSEKKDSALYTEKFHHVKFACSVKQFGGRPASGALLLTTTGMLCSILLPQSTSQVAMVMATESLAPTRIFIKAADICYGKNGHFLLAVSNGDLSMPIQCYKVSVRKAEDKCVITSQSLLSFFLFEAPKEALMEQVSKEKNCHISHIKWIMREDADSVVVSATSDKISCLQVWELREKALPVHKSLGKSETPQFFNTVLWQYQCHFQYNSRVTSLATSKLSLLNNVSSGYVVATFADNSIHCLYRDTLKHLVSTTLTICPRYFDEPLARYPKTSIKISNIDMSWLGNILLVIDSDDSLHMFKLPPQIDSSTPLSVPYCTTILEYCMMSGFDWLDLLLVLRPGMLDAICDRLTESFNRQPSAVQQFFYVQYLCMKISLCRLSVQGQVKAHDLAQFLMLHSISTAFKSLLRPSEMSSHDKSPADSLANVIAEGQTDVDKVLMHLEAKEFTVEPSTLQSLQQLIQWVADLALNLLVKLPDSRPSMGKVYELLRDVKALNMLREMLVLIRIWGLLRPACLPVFIKSDGSLDVLALLFRLLSRLVQNVNEPDDTLIDECCLLPSQVQIQLFQPSNNRAVLASPQLVQQILPLQLEYNNDPECLMSSTDSGATQTVDSIRHLYLGRTPRAIKQCVRCGGSAGTIPVTRTAAIRAWDQRWLRSCQCGGLWRMQVYT
Length810
PositionTail
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.08
Grand average of hydropathy0.035
Instability index48.24
Isoelectric point7.23
Molecular weight90845.29
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription, DNA-templated	GO:0045893	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26195
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.45|      15|     157|      31|      45|       1
---------------------------------------------------------------------------
   31-   45 (27.30/17.36)	LCSI....SSSNV.VAFSTE
  185-  204 (18.14/ 9.03)	LCSIllpqSTSQVaMVMATE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.63|      15|      26|     337|     351|       2
---------------------------------------------------------------------------
  337-  351 (31.63/23.61)	NTVLWQY.QCHFQYNS
  365-  380 (21.99/14.02)	NNVSSGYvVATFADNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.25|      24|      27|     750|     774|       4
---------------------------------------------------------------------------
  750-  774 (38.95/28.79)	TVDSIRHLYL.GRTPRAIKQCvRCGG
  778-  802 (41.29/26.18)	TIPVTRTAAIrAWDQRWLRSC.QCGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26195 with Med16 domain of Kingdom Metazoa
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