<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26194

Description Mediator of RNA polymerase II transcription subunit 12-like Protein
SequenceMFNSSLLYEKRPLKKPKIGPPDVYPQEPKQKEDELTSVNVKHGFLTMTHLSDEFGTARNCNISASKVGDYFNDIIKRKEELSMLPDSGRKRQQINPKDNFWPATIRTKNAIELWFKDLAGNKPLMHLSKKAPNFNKKEEIFIMLCEYQVPMMRAAWFIKLSSAYTVAVSEAKIKKRQMPDPTTEWTGTMLKFLKEQILKLQDYYSQGEKPPQTPSLTQAATTETEQKLAMRHWIYCTQLLKYMYEEGLMDRQEVLTWILELLEKMRSQPSDDGILRLLMPLCLQYLDEFVQSELLSRRLAHLCCKKLGYMLNNVAENNLITSPQSETKTEQKDNEKEKKDVPVTNPMQSTLMEYQNCPHHRDIVLQLSTVIQTITLECPTALVWCGTGVGSVWHGSPLDLLPMVPSSLPMAARCDMNTYRKQLQFAEHCIRERSKRAEGRWCTEKWQNSSAGTITNRVLAALDALDRHRFDKMDSTNSLDTLYTKVFGGNSDQENSVVKLLCEWAVSPERTGEHRALAVAALLDRRQSDSATNGDQETAPGDDKDSNCSVPGGPPMFQQLLMKFLDSDAPVPAPDDCPQKKTAFSNLVHLFAELIRRDVFSHDAYMCTLISRGDLLGPEETTDVSTSHQSHHTKLEDHSHNMDFDDATIDHDLDKILQNIKEDQQNSMDVPDSPKEHDHGHHPHQSSIGHVPMETDHNDHKVKPSRHLLYTTHFPLYQDDPFSQHDCNQRHVLLYGVGKVRDEARHTVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRNEFNFEATTQKCQSLSYFDQHLVTWQCSVTVIEMLNSFATGNSNYLPVQEHVAFLFDLMELALNIYGLIDVCIQILKELPEVETQLYNKNSVLTRNYTTSLSLYVVGVLRRYHCCLLLSPEQTSAVFEGLCKVVKHVSNPGDCSSAERCILAHLYDLYSSCSLLKSKPHTGEPFGNAYPKIRQALYTALQPTPSSNYVYNSGYMQEVFTNPRRGGRIESSWARPLNESANNRYSFVSNAVIYVCRETDNERLNDLAIMCAEMTACCNSLASEWLGVLLALCCPIAHPGYYTDVLAQLDIQDVSIHNALAVFTCILIARHCFSLEDFVGRVALPSLLKVKTLDNGSGAAEGGMRLTCHLLLRLFRTAEGPQPGLYSVGSPPLTAPRPPLGVRLSCDRHLLAAAHRNIHVGPVLAVLKAVLIVGDATAREGTELSISHILGTSDLMSGGDGPSLDLAQSSTGNAESTASLSAFACHVLREICSQQWVLERCLSHPEELCDSDNLLDPLLSHSQAQRLLHMICYPDAGTSIEELDQKSMISRILENLEQWTLRMSWLDLQLMFRQFTPNSQELSQWLDTVAKAAIDVFQLNSSSSNSPKSDEKKPEIKNRAQNSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGGWCKETKSKGRGGSDSQSLLSHQPFLTLVLTCLKGQEEGQREGLLSSLHQQLSQLVQLARDGNLQDICNNERTLDGLQLRFALVGGVFEAFQRNPSATTDWALLLVQLVTNGLIDLHTHSELFTTVIDMLATLIHSALATDSQDEGRKMYQNLMKKLKKEVGERHNASLQHVRQLLPLPRSVTEIIAVEPIGWVTDGKGNKISFDSLDKKHGFQVTDKQRVSSWDILEGMKNPAPLFWAWFGAVRLERKPLTGEDNHRLLKYHTHNLQRPPSHYLDPPPLPPEDLEPVPDKPLKDCDLKADTPSSVDQSPAAMGKGRGKGQRRPRKPKTVPGQLPVNPMGMNQPQMGQGQMPMQVPGPNPQMHNMGGYGQGPMPQQGQQYGNNQQQWYNQQQQQQGYYPPQMANVNRFERPQINQSKQALSNLLRSRHPLNMGPTAQTPQGPGPQANYGPMRSFPRQPMRQQHPGAIQQNQNMFPQQYGSMQAGMNQLYGNYGGTPNTMMPNNMQASQQMMQGSQPNMFAGQQQGFGQPRPPQPDYRGMAQNPRAQYMQQAPNVTMNANMNTMGGMGGQGGPAPPYSRQTPQGMQQGVQQPNQFQQQRMRQQMMAMQQQQQQQGGPQGNTSSLVAHLQRQMNPNPYQHQPPPYNM
Length2064
PositionKinase
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.07
Grand average of hydropathy-0.542
Instability index48.24
Isoelectric point7.01
Molecular weight231878.30
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26194
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.49|      19|      19|    1753|    1771|       1
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 1753- 1771 (41.16/18.58)	L...P....VNPMGMNQP...QMGQGQMP
 1870- 1894 (23.99/ 7.37)	MrsfP....RQPMRQQHPgaiQQNQNMFP
 1914- 1935 (26.34/ 8.90)	T...PntmmPNNMQASQ....QMMQGSQP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.46|      19|      19|    1994|    2012|       2
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 1786- 1801 (28.87/ 9.52)	GYGQG.PMP.QQ.....GQQYGN
 1940- 1956 (25.36/ 7.47)	GQQQGFGQP.R...pP..QPDYR
 1957- 1972 (24.77/ 7.13)	GM...AQNPrAQ....YMQQAPN
 2002- 2023 (32.47/11.62)	GMQQGVQQP.NQfqqQRMRQQMM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.56|      21|      23|     690|     710|       3
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  670-  684 (19.73/ 6.85)	.VPDSPK..EHDHGHHP..H....
  690-  710 (41.48/23.13)	HVPMETD..HNDHKVKPSRH.LLY
  713-  735 (28.34/13.29)	HFPLYQDdpFSQHDCN.QRHvLLY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.02|      20|      23|     276|     295|       4
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  276-  295 (35.91/23.98)	RLLMPLC...LQY.LDEFVQSELL
  297-  320 (26.10/15.15)	RRLAHLCckkLGYmLNNVAENNLI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.80|      20|      23|    1306|    1325|       5
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 1306- 1325 (34.70/23.68)	IEELDQKSMISRILEN...LEQW
 1329- 1351 (34.10/23.13)	MSWLDLQLMFRQFTPNsqeLSQW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.00|      18|      23|     338|     358|       6
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  338-  358 (27.83/26.35)	KKDV..PVTNPMQSTLMEyqnCP
  360-  379 (24.17/13.03)	HRDIvlQLSTVIQTITLE...CP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.05|      17|      17|    1256|    1272|       7
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 1256- 1272 (33.61/20.53)	EICSQQWVLERCLSHPE
 1273- 1289 (30.43/17.81)	ELCDSDNLLDPLLSHSQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.01|      17|      17|    1686|    1702|       8
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 1665- 1681 (26.03/10.14)	LERKPLTGEDNHRLLKY
 1686- 1702 (32.44/14.51)	LQRPPSHYLDPPPLPPE
 1704- 1720 (26.54/10.49)	LEPVPDKPLKDCDLKAD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.72|      13|      23|    1428|    1440|       9
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 1428- 1440 (22.41/10.06)	KGRGGSDSQSLLS
 1453- 1465 (23.31/10.76)	KGQEEGQREGLLS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.42|      13|      23|     543|     555|      10
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  543-  555 (26.15/14.61)	DKDSNCSVPGGPP
  566-  578 (26.26/14.71)	DSDAPVPAPDDCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.37|      16|      19|    1022|    1037|      11
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 1022- 1037 (29.54/20.96)	CRETDNERLNDLAIMC
 1044- 1059 (28.83/20.26)	CNSLASEWLGVLLALC
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.77|      32|     115|    1097|    1137|      12
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 1097- 1131 (50.33/44.29)	HCFSLEDFVGRVALPSLlkvKTLDNGSGAAEGGMR
 1214- 1245 (53.43/28.68)	HILGTSDLMSGGDGPSL...DLAQSSTGNAESTAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.52|      26|      55|     446|     471|      15
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  446-  471 (46.06/33.67)	WQNSSAGTITNRVLAALDALDRHRFD
  504-  529 (45.47/33.14)	WAVSPERTGEHRALAVAALLDRRQSD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.91|       9|      21|     233|     243|      22
---------------------------------------------------------------------------
  233-  243 (13.64/15.10)	WIycTQLLKYM
  257-  265 (17.27/ 8.65)	WI..LELLEKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.83|      14|      17|    1814|    1830|      24
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 1814- 1829 (21.64/15.47)	QGyyPPQMANVNRFER
 1834- 1847 (21.19/ 7.94)	QS..KQALSNLLRSRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.76|      25|      28|     909|     933|      25
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  909-  933 (45.96/32.86)	CKVVKHVSNPGD.CSSAERCILAHLY
  939-  964 (40.79/28.16)	CSLLKSKPHTGEpFGNAYPKIRQALY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.15|      11|     730|     244|     256|      26
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  244-  256 (16.27/17.36)	YEEGLMdrQEVLT
  977-  987 (22.88/15.20)	YNSGYM..QEVFT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.69|      17|      17|    1611|    1627|      30
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 1611- 1627 (30.69/19.74)	GWVTDGKGNKISFDSLD
 1631- 1647 (30.00/19.12)	GFQVTDKQRVSSWDILE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.85|      15|      39|     839|     859|      32
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  830-  844 (24.50/28.86)	VAFLFDLMELALNIY
  851-  865 (24.35/ 9.59)	IQILKELPEVETQLY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26194 with Med12 domain of Kingdom Metazoa
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