<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26191
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MGDDGSWRTPAFRQSVVSKIDEAIRQSGMNTSRNSIEMENHVFQKAKTKEEYLGYVARLILHVREMNTKKGAGMGVPGQNQGAPGVPDPINALQTLAIQGTRNPLMTMGGNQPGPMGAQQQIAASNLLQNLNRGPGQAMNNMQQGMVQRPNMGMGPNGGPLPNQLGNQMSQMNTQMANQLAGQMPNQMGNQMQGPVQNQMANQLPGQMQMGGPMQNSMGPMGNQMPNQMLSQMQSNKQGPMMMNGPNTGFPRNSTPNQFLSQSPSPSVQSPAGLSGAPPSNQMVASPALAPSPSSQMGMLGAGPPRSVGMVPSPGSSLNTPGQPNQSPMGMQDEQAYREKVRQLSKYIEPLRKMIARMGNDGEHVEKLSKMKKLLEILSNPQQRMPLETLKKCEVVLEKLDFKRSDGSVPTSTSGHLPIKEHHVFNPLLEAVSNNLQSSVINHTLHRTFGPTLEALFGPEIKLVPPLKKMKLEEPTSDIPDVLQGEIARLDQRFKVSLDPNQQPGSKSIQLTCWLDDKQLPCVPPISLVVPEDYPKSAPSCHMAAHEYNATQFLSAVQTALLARIKKLPKYFSVSQLLDTWEMSVRQASAPTSVPVFPTTLLMGL |
Length | 605 |
Position | Tail |
Organism | Tribolium castaneum (Red flour beetle) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia>
Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.527 |
Instability index | 47.49 |
Isoelectric point | 9.38 |
Molecular weight | 65751.94 |
Publications | PubMed=18362917
PubMed=19820115
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26191
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 108.86| 21| 21| 162| 182| 1
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162- 182 (43.73/16.57) PNQLGNQM.SQMNTQMANQLAG
185- 206 (36.92/12.79) PNQMGNQMqGPVQNQMANQLPG
256- 276 (28.22/ 7.95) PNQFLSQS.PSPSVQSPAGLSG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 89.93| 22| 24| 278| 301| 2
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139- 155 (34.71/ 8.23) MN.................................NMQQGMV......QRPN...MGMG
213- 234 (30.93/ 6.50) ...................................PMQNSM..GPMGNQMPNqmlSQMQ
243- 298 (24.29/ 7.57) MNgpntgfprnstpnqflsqspspsvqspaglsgaPPSNQMVaSPALAPSPS...SQMG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 56.54| 19| 19| 358| 376| 4
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358- 376 (32.12/23.29) MGNDGEH..VEKLSKMKKLLE
378- 398 (24.42/15.88) LSNPQQRmpLETLKKCEVVLE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 40.28| 10| 21| 422| 431| 6
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422- 431 (20.17/13.11) HHVFNPLLEA
446- 455 (20.12/13.06) HRTFGPTLEA
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