<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26186

Description Mediator of RNA polymerase II transcription subunit 23-like Protein
SequenceMGEPLTNVLTDILKVEGIEEAFSCFLVHRPSAEKEKVAVWQQELNTALRSIPQEQLDTALRQYLNTAVLCSQSKLQLLMELLESVVRNGTIGARIVCEVVMNFDKLQHTNARFWIECFKLVRKIIDLVEYKGVREIMKGCCEKAKSLPWRLNAGLQPQTQALLSVAERIMDRNACLLPGYLLVNELQKAYPDCPHWRLAALFSDYVGSFRACAQMVAIVGQAEMRPVVEHSGCPEHLVNPWKLDPCTLRFSLKGTLPYAPELLEKQTGLLRYVLEQPYSRDMVCGMLGLQKQHKRHCAALEEQLVELVILALERTENEGDESATQGLWLHLSSQLIYFVLFQFASFPNIVISLHSRLQGRDLRRGRDQLMWVLLQFISGSIQKNPLSNFLPVLRLYELLFPEQEPPLPVPDFNQPQCTRQMAMTCIWIHLTKKAQAEMTNLTWPIPAKLRNHHDFLQQLVPPNNTVLAMGNDYRIALLCNAYSTNPDYYSKPMAALVETIQGSPKSTAPPTAPLSMAVLDSLTVHSKMSLIHSIVTHVIKLAQAKLGMPLSPALVETYSRLLVYTEIESLGIKGFISQLLPTVYKSHAWGTLYTLLEMFSYRMHHIHPHYRVQLLSHLHSLAAVPQANQTQLHLCVESTALRLITGLGSGEVQPELSRFLAEPKTLISAESEELNRALVLTLARATHVTGADGSWCHELLATIAQSTPHAWAPHTLECFPRALAEFFTQHAVPKENKQQLKKAVEEEYRKWSSMNNENDMMAHFGVAGAPPLFLCLLWKMLLETDHITPIAYKILERIGARALSAHLRKFCDCLVFEFSNSPGGQHVNKCVDTINDMIWKYNIVTIDRLVLCLALRTQEGSEAQVCSFIIQLVLLKATEFRNRVQDFVKDNSPDHWNQTNWHEKHLEFHRKYPEKFAPEEQSSGYHPYFGNVCLRFLPVFDIVVHRFLEIPQVTKSLEILLEHLGCLYKFHDRPVTYLYNTLHYYETRLRDRPPLKRRLVAAVLGTLKDSLSEPYQLYLGRAADEMWTPELDYYIQVVKRVVDILGGATANSVIDWRFNEFPNAGAHILYTSCVELMALSAGPVAVANGLLDVVAKGYVTIPSSDIHQWVNAVGLILAALPVSYWSVLHDRLVATLNELETWNFDCSPFRLFDFKETHAGLLHNNFSYMLALAHSVWHHAGPGQIASVPRWARECLPAVVRSEEQFLYVCHLVGPFLQRFNVAIVELTSALYELLAQVDHAHSELKYMDPICDLLYHIKYMFVGDSMKKELETVVRRLRPPLQMRLRFIAHLAIEEVNAS
Length1300
PositionTail
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.09
Grand average of hydropathy-0.024
Instability index44.80
Isoelectric point6.68
Molecular weight147943.97
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26186
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     479.75|     159|     453|     625|     834|       1
---------------------------------------------------------------------------
  550-  652 (114.38/71.76)	LSPALVETYSRLLVYTEIESlgikGFISQLLPTVYKS..HAWG..TL....YTLLEMFSyrMHH.......IHPHYRVQL..............................................................................................lshlhslaavpqanqTQLHLCVEsTALRLITGLGSGEV
  674-  834 (194.27/200.16)	LNRALVLTLARATHVTGADG....SWCHELLATIAQStpHAWAphTLecfpRALAEFFT..QHA.......VPKENKQQLKKAVEEEYRKWSSMNNENDMMAHFGVAGAPplFLCLLWKMLLETDHitpiaykilerigARALSAHLRKFCDcLVFEFSNSPGGQHVNKCVDTI......................................
 1171- 1297 (171.10/98.41)	....................................................ALAHSVW..HHAgpgqiasVPRWARECLPAVVRSEEQFLYVCHLVGPFLQRFNVAIVE..LTSALYELLAQVDH.............AHSELKYMDPICD.LLYHIKYMFVGDSMKKELETV..............vRRLRPPLQ.MRLRFIAHLAIEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.47|      24|      35|     322|     345|       4
---------------------------------------------------------------------------
  322-  345 (41.69/22.61)	SATQGLWLHLSSQLIYFVLFQFAS
  355-  378 (40.78/21.97)	SRLQGRDLRRGRDQLMWVLLQFIS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.26|      24|     452|      64|      87|       6
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   64-   87 (38.96/24.46)	LNTAVLCS...QSKLQLLMELLESVVR
  514-  540 (35.30/21.50)	LSMAVLDSltvHSKMSLIHSIVTHVIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.94|      22|     952|     171|     198|      10
---------------------------------------------------------------------------
  171-  198 (38.73/33.34)	DRNACLLpgyllvNELQKAYPDCPHWRL
 1130- 1151 (42.21/22.76)	DRLVATL......NELETWNFDCSPFRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26186 with Med23 domain of Kingdom Metazoa
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