<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26184

Description F-box-like/WD repeat-containing protein ebi
SequenceMSFSSDEVNFLVYRYLQESGFQHSAYTFGIESHISRSNINGALVPPAALLSILQKGLQYTEAEISIGEDGLEQRLVESLSLIDAVMPDVVASRQNQQNAQKQPIKSEITDTNGEEAVVSTQNENMEVDTSIEIPTSKATVLRGHESEVFICAWNPTTDLLASGSGDSTARIWDMSDNTASPNQLVLRHCIQKGGTEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWTTDGRLASTLGQHKGPIFALKWNKRGNYILSAGVDKTTIIWDAASGQCTQQFSFHSAPALDVDWQTNTSFASCSTDQCIHVCKLSLDKPIKSFQGHTNEVNAIKWDPQGNFLASCSDDMTLKIWSMKQDNCVHDLQAHSKEIYTIKWSPTGPGTQNPNMNLILASASFDSTVRLWDVERGACIHTLTKHTEPVYSVAFSPDGKFLASGSFDKCVHIWSTQSGQLVHSYKGTGGIFEVCWNSRGDKVGASASDGSVFVLDLRKL
Length490
PositionTail
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.08
Grand average of hydropathy-0.308
Instability index37.31
Isoelectric point5.23
Molecular weight53654.27
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function 
GO - Cellular Component
histone deacetylase complex	GO:0000118	IBA:GO_Central

GO - Biological Function
transcription corepressor activity	GO:0003714	IBA:GO_Central

GO - Biological Process
histone deacetylation	GO:0016575	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26184
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     337.97|      33|      39|     208|     240|       1
---------------------------------------------------------------------------
  153-  183 (48.24/22.40)	WNPTTD.........LLASGSGDSTARI..W.D.MS.DNTASP.NQ.
  208-  240 (58.45/28.41)	WNCDGS.........LLATGSYDGYARI..W.T.TD.GRLASTLGQH
  249-  282 (43.53/19.63)	WNKRGN.........YILSAGVDKTTII..WdA.AS.GQCTQQFSFH
  291-  323 (40.81/18.03)	WQTNTS.........F.ASCSTDQCIHVckL.S.LD.KPIKSFQG.H
  332-  365 (53.71/25.62)	WDPQGN.........FLASCSDDMTLKI..W.SmKQ.DNCVHDLQAH
  374-  416 (43.42/19.57)	WSPTGPgtqnpnmnlILASASFDSTVRL..W.D.VErGACIHTLTKH
  425-  457 (49.80/23.32)	FSPDGK.........FLASGSFDKCVHI..W.S.TQsGQLVHSY.KG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26184 with Med16 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SRQNQQNAQKQPIKSEITDTNGEEAVVSTQNENMEVDTSIEIPTS
92
136










Molecular Recognition Features






MoRF SequenceStartStop




1) NFLVYRYL
2) VFVLDLRKL
9
482
16
490