<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26182

Description Cyclin-dependent kinase 8-like Protein
SequenceMTTLMMDYEFKMKTQNERVKVEDLFDYEGCKVGRGTYGHVYKGRRKDGSDNRDYALKQIEGTGLSMSACREIALLRELKHPNVITLIRVFLSHNDRKVWLLFDFAEHDLWHIIKFHRAAKANKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPLEKDWEDIKKMPEHPTLVKDFKKQSYINCSLVKYMDRHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDAYFSEDPLPTQDVFAGCPIPYPKREFLTDDDQEEKAESKQRQNQQQQQQQQQQQSQQQQQQQQQQQQQQSQQQQSGNGDNHGNPSKRVRLSGNAHPGQVNPQAIPISQQQEFHQQQMMYNNGSQQQQNFQQRF
Length470
PositionKinase
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.09
Grand average of hydropathy-0.802
Instability index53.34
Isoelectric point8.77
Molecular weight54923.87
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26182
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.98|      15|      15|     375|     389|       1
---------------------------------------------------------------------------
  375-  389 (29.58/12.82)	SKQRQNQQQQQ..QQQQ
  392-  406 (30.56/13.49)	SQQQQQQQQQQ..QQQQ
  444-  459 (21.83/ 7.54)	SQQ.QEFHQQQmmYNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.36|      25|      39|     106|     143|       2
---------------------------------------------------------------------------
  107-  134 (42.73/52.22)	HDLWhiiKFHRAAKANKKPVM..VP.KGMVK
  148-  175 (38.63/14.98)	HSNW...VLHRDLKPANILVMgeGPeRGRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.84|      10|      15|     412|     421|       4
---------------------------------------------------------------------------
  412-  421 (21.15/13.76)	SGNG.DNHGNP
  428-  438 (15.69/ 8.38)	SGNAhPGQVNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26182 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SEQAMQDAYFSEDPLPTQDVFAGCPIPYPKREFLTDDDQEEKAESKQRQNQQQQQQQQQQQSQQQQQQQQQQQQQQSQQQQSGNGDNHGNPSKRVRLSGNAHPGQVNPQAIPISQQQEFHQQQMMYNNGSQQQQNFQQRF
331
470










Molecular Recognition Features






MoRF SequenceStartStop




1) SKRVRLS
422
428