<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26177

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMDDDEVNEVRNPFPSPPSHYTRYSSHNLKLLALLKERAPDHQDHPVNQHQLLSDQKDVPEWDLGLLEKPRVDWILDEPDAHYNVFGERWPVKEKHPSLAEAGITQLYSSDPSVDRRPALVSVLKSLLVTYSNLISSLLDPPPLEGAPEWNRHMAWLKTLSLNLLAAANDLRPMQARCSLELMMQRQLELRREETRNIHDKCDALEAKLKELRATPLQSSQDITKHFSDDEGDADEPLAPLPDEPEIVDGDEEMEQDETAAPSRAEPASKETAEPEPEATTTEETPSKAPSPKPQLSMTTAEDPPQGSELDPSLKPMDVNMDDGEEGEGKKEGKLELNMTGLGPDGLPLEGSHDLSQLDPADSLNGHYTDIRALLCLPRLPEIFGV
Length385
PositionMiddle
OrganismCoprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Psathyrellaceae> Coprinopsis.
Aromaticity0.04
Grand average of hydropathy-0.771
Instability index52.02
Isoelectric point4.51
Molecular weight42939.32
Publications
PubMed=20547848

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	RuleBase:RU364060
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26177
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.19|      24|      47|     238|     262|       2
---------------------------------------------------------------------------
  238-  262 (37.33/20.00)	APLPdEPEI.VDGDEEMEQDETAAPS
  288-  312 (34.11/14.27)	APSP.KPQLsMTTAEDPPQGSELDPS
  314-  331 (20.76/ 6.03)	KPM..DVNM.DDGEEGEGKKE.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.60|      10|      49|      36|      45|       4
---------------------------------------------------------------------------
   36-   45 (21.43/12.33)	ERAPDHQDHP
   87-   96 (21.16/12.08)	ERWPVKEKHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.40|      24|      27|     108|     134|       5
---------------------------------------------------------------------------
  105-  119 (19.46/ 6.02)	............QLY.SS..D.PSVDRRPAL
  120-  149 (26.95/19.22)	VSVLKSLLVtysNLI.SSllDpPPLEGAPEW
  153-  172 (22.99/ 9.16)	MAWLKTLSL...NLLaAA..N....DLRP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.44|      21|     129|     204|     224|       6
---------------------------------------------------------------------------
  204-  224 (33.06/18.72)	LEAKLKEL..RATPLQSSQDITK
  334-  356 (30.38/16.67)	LELNMTGLgpDGLPLEGSHDLSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26177 with Med7 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELRREETRNIHDKCDALEAKLKELRATPLQSSQDITKHFSDDEGDADEPLAPLPDEPEIVDGDEEMEQDETAAPSRAEPASKETAEPEPEATTTEETPSKAPSPKPQLSMTTAEDPPQGSELDPSLKPMDVNMDDGEEGEGKKEGKLELNMTGLGPDGLPLEGSHDLSQLDPADSLNGHYTDI
188
370










Molecular Recognition Features






MoRF SequenceStartStop




1) SHYTRYSSHNLKLL
18
31