Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MTSSFSGGSRSLHPTNTIPTPASSAANTVPATFEDNEVDVMMDEGSDTGSNKRRRTSSSSYDRASQTMPPALRHRGNLADDIPPPIPTEQELLSQPDVSPYYLVCSNPRQPSYPDLTDNLLALYGLRDIANSVARKNHITGAKNKIRKSYKGFTSDLPGRNVVATRASQTEVEPGGEAGGGGGDYFATLLQFPDEEWRNLQVIGKEISKGIDMGKLRKGLSMGRGDIPGFDSSILGLDEESRGRKTPHVGSTTPAVGAAVGTPGHANGSTPGGPSPAGDDGRPKRGKRRRNDGGDDDNGINGSIGGVAGGGGGGNHGQGPGVGPGAIVEGTAWDGEKRKKKRKKVNTLLNI |
Length | 351 |
Position | Head |
Organism | Tuber melanosporum (strain Mel28) (Perigord black truffle) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.763 |
Instability index | 50.72 |
Isoelectric point | 9.02 |
Molecular weight | 36694.11 |
Publications | PubMed=20348908 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP26174 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 108.99| 32| 47| 257| 290| 1 --------------------------------------------------------------------------- 257- 289 (58.33/18.88) GAAVGTPGHANGSTPG.GPSP..AGD..DGRpKRGKRR 306- 342 (50.66/11.28) GVAGGGGGGNHGQGPGvGPGAivEGTawDGE.KRKKKR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 93.07| 28| 101| 63| 97| 2 --------------------------------------------------------------------------- 63- 97 (44.92/31.88) RASQT.MPPALRHRGNLADDIpppipteQELLSQPD 166- 194 (48.15/20.98) RASQTeVEPGGEAGGGGGDYF.......ATLLQFPD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.60| 17| 88| 132| 160| 3 --------------------------------------------------------------------------- 107- 127 (24.14/24.69) NPRQPSYPDLTDNllaLYGlR 144- 160 (31.46/10.93) NKIRKSYKGFTSD...LPG.R --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GSIGGVA 2) GVGPGAIVEGTAWDGEKRKKKRKKVNTLLN 3) PYYLVCS 4) RPKRGKRRRN | 302 321 100 282 | 308 350 106 291 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab