<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26174

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTSSFSGGSRSLHPTNTIPTPASSAANTVPATFEDNEVDVMMDEGSDTGSNKRRRTSSSSYDRASQTMPPALRHRGNLADDIPPPIPTEQELLSQPDVSPYYLVCSNPRQPSYPDLTDNLLALYGLRDIANSVARKNHITGAKNKIRKSYKGFTSDLPGRNVVATRASQTEVEPGGEAGGGGGDYFATLLQFPDEEWRNLQVIGKEISKGIDMGKLRKGLSMGRGDIPGFDSSILGLDEESRGRKTPHVGSTTPAVGAAVGTPGHANGSTPGGPSPAGDDGRPKRGKRRRNDGGDDDNGINGSIGGVAGGGGGGNHGQGPGVGPGAIVEGTAWDGEKRKKKRKKVNTLLNI
Length351
PositionHead
OrganismTuber melanosporum (strain Mel28) (Perigord black truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.04
Grand average of hydropathy-0.763
Instability index50.72
Isoelectric point9.02
Molecular weight36694.11
Publications
PubMed=20348908

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26174
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.99|      32|      47|     257|     290|       1
---------------------------------------------------------------------------
  257-  289 (58.33/18.88)	GAAVGTPGHANGSTPG.GPSP..AGD..DGRpKRGKRR
  306-  342 (50.66/11.28)	GVAGGGGGGNHGQGPGvGPGAivEGTawDGE.KRKKKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.07|      28|     101|      63|      97|       2
---------------------------------------------------------------------------
   63-   97 (44.92/31.88)	RASQT.MPPALRHRGNLADDIpppipteQELLSQPD
  166-  194 (48.15/20.98)	RASQTeVEPGGEAGGGGGDYF.......ATLLQFPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.60|      17|      88|     132|     160|       3
---------------------------------------------------------------------------
  107-  127 (24.14/24.69)	NPRQPSYPDLTDNllaLYGlR
  144-  160 (31.46/10.93)	NKIRKSYKGFTSD...LPG.R
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26174 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPGFDSSILGLDEESRGRKTPHVGSTTPAVGAAVGTPGHANGSTPGGPSPAGDDGRPKRGKRRRNDGGDDDNGINGSIGGVAGGGGGGNHGQGPGVGPGAIVEGTAWDGEKRKKKRKKVNTLLNI
2) MTSSFSGGSRSLHPTNTIPTPASSAANTVPATFEDNEVDVMMDEGSDTGSNKRRRTSSSSYDRASQTMPPALRHRGNLADDIPPPIPTEQELLS
227
1
351
94










Molecular Recognition Features






MoRF SequenceStartStop




1) GSIGGVA
2) GVGPGAIVEGTAWDGEKRKKKRKKVNTLLN
3) PYYLVCS
4) RPKRGKRRRN
302
321
100
282
308
350
106
291