<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26169

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPQAMTPGDLVDASRHDFQHGTPNHSGSAPGKQAELVVRNPRLPHITQGFIELRLLVSRLVQDSHNRLQGMIGLLAEGGRSDGDKKARIIEHMLERRKQFIKLLVLTMWAKNAQAVSEVIDLKVFLDTRQEIFHRVVWNLYEVRRKMSYARIPNPDLDTAVRVLSTGRANTAMTRRYVPPKKLTSGETLKILRDLNTLLSLRLALHEKLPPYFRDYTIASGRVTFTVADEFEADLSIGDEDPTSQLYLVDFRFIFKPSASTLPAGRIRDEVERTGNKILEQKGLEGIYDYLHGFVMTDKICTLARQFQIMLTGRWTENLVVEMRKRTLVVQYWVSRVTEGATKSWIEVGIKRGTGGRPSHVGVRWIRDGKAVQDQEVPLDVAVLSAENLIKTVVAMHTKHILTSIRGRLAHSPVFPLSAMVLTTHSTDSFNSSLKLQLTPSRPIKFLIEPITGRFALHPLTMVSTHVEAAMNNSPTGVEEVIIRLKFVLTQEEVETRARSMGWEVLKVLNIRKEELKGFFPNSTKYITYLRRKGWGKEWVVVMVLAETGQTWWVAKVYEAPSQWSMSMALEIPVQGEANATYGFLGNLEKISSAMITLYVNQSVLVEKGVQHKLQPSKVADPKLTIPDLYIRFSSLIRANWGIDVLRLTFQGLGTEGKCIVTVLGRTKEPMTQLGSTNISAADSDVSFHPQSGSYAIRFNINVGESVIEPLTEKLHRIERLIRFVAVIRRFKLPCLDVSLGRIAFTYDTESNSSAEVSFSGDREMKLHLPPRSPHIRIKGFLEHRLNVSGLETVVMALTVTLPLLLAFERIEAAVGDRSDGHVFVLSRGVDWFRIYYRRLGVVLDWQLQCRKSVLHWFVRDAASSNPESEAEIVGGEGRRKAEELKGIWSGEVEGDWEPLKSGAAAGLREVGALAWKIHELIYAGRRAIS
Length930
PositionTail
OrganismTuber melanosporum (strain Mel28) (Perigord black truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.08
Grand average of hydropathy-0.153
Instability index39.73
Isoelectric point9.48
Molecular weight104813.86
Publications
PubMed=20348908

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26169
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.31|      17|      28|      59|      75|       1
---------------------------------------------------------------------------
   59-   75 (28.93/16.05)	RLVQDSHNRLQGMIGLL
   88-  104 (28.38/15.63)	RIIEHMLERRKQFIKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.36|      35|      38|     396|     433|       2
---------------------------------------------------------------------------
  378-  414 (47.99/40.41)	PLDVAVLSAENLIKTVVAMhtKHILTSIRG.RLAHSPV
  416-  451 (53.37/43.62)	PLSAMVLTTHSTDSFNSSL..KLQLTPSRPiKFLIEPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.05|      31|      89|     619|     654|       3
---------------------------------------------------------------------------
  619-  650 (51.42/38.53)	VADP...KLTIPDLYIRFSSLIRaNWGIDVL.....RLTF
  707-  745 (43.64/19.73)	VIEPlteKLHRIERLIRFVAVIR.RFKLPCLdvslgRIAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.85|      47|     520|     326|     376|       4
---------------------------------------------------------------------------
  326-  376 (75.10/67.41)	RTLVVQYWVSRVTEGATKSWIE.VGikrGTGGRPSHvGVRWIRDGKAVQDQE
  851-  898 (78.75/56.96)	RKSVLHWFVRDAASSNPESEAEiVG...GEGRRKAE.ELKGIWSGEVEGDWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.57|      24|      28|     153|     180|       5
---------------------------------------------------------------------------
  126-  149 (42.61/31.92)	LDTRQEIFHRVVWNLYEVRRKMSY
  157-  180 (39.96/21.55)	LDTAVRVLSTGRANTAMTRRYVPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.40|      18|     728|      41|      58|       6
---------------------------------------------------------------------------
   41-   58 (35.32/19.68)	PRLPHI.TQGFIELRLLVS
  771-  789 (32.07/17.30)	PRSPHIrIKGFLEHRLNVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26169 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPQAMTPGDLVDASRHDFQHGTPNHSGSAPGKQAELVV
1
38










Molecular Recognition Features






MoRF SequenceStartStop




NANANA