<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26164

Description Uncharacterized protein
SequenceMSNPSSWARSFQHAQAGPQPWGNQPGQDAQNGLARSSRLDIPNVVRPPPARQPPPDPFLQPSHPRAVTEKPLIIDLTDSNPSHFQRALINTAKMDGVFNIPPVTPTTIETPVVMEPVKPYDGALCSRSSIQNSRTRKRLKFAPQACPPASPQFIQPSKVYQGAKSSLTPPALSRGNSSSRQKQIQPQPSKSDFSKPNTRRDNKPKPYLLEVPPGAMMFPSSRCSDFFPWKGNHPEDHVTDAQARNGQYDKLYVGKGNASARPSLVPSLKGKSALPSLSSLFLTVLDKRQKYNRLTTPPTFKPPPRVTLPDMRREAWLRDLASPLVPLRRLSRTIPHGLKGPILLDQCAAKSIPTARAVWFARCVGANELRGLKRKGVGSFAVGSETKWLKEWTIQVTRFLERTISECGSSSDLWKQKMVYAVRLSAHLFGENLLDRTLFLEWYLSYLETCSLDMLPIAYLMLSIYWDELLKTRRLGRRLAEALLGKAEAILAAEDKETYAPLMQKLSILLTDILFLHRESLIVSNSWESYRSILEACVDRRCSFVRSCLQNISQRNKNLLSPMQARQNDSVSSGQRKLINMLDSIAMLYSIDEIWEKCCSLEVAEDQLVRCLCQWATTSLRVGKHRIYIVAGLLGCARRSGISVQDHMKSFLEGFGSNVKGSKDDVYLLVSELVRSKTFSVALYMKWLISRGILSEYTITRESPCHVRLLAEVPVTSAPNHIRNLRSILLSDHGFSVEDEVTSLEVSKRILSSKIPAVFYGDLRAGGSVERFAPEELAYFGRLNRAVMYELGLWIRESVRKHVVKGAPVGRDNWRDLSVEVGITAVRTEEFVMIRQLLEIFKDFLILAEVVRMVTSSDSSATLSSAADTVSYNIEVFSSLGAVKDNLQLLYNRYKKLRMRRTLEKYVLVSLVDLASFPEAQAEIRRELETELANYDKRFPRASVAYSPVSENMGDMFEHGTADSNEEIDRLLRNGATIDKHNLSRLFETIVSRMETSFDDRESVGALSSSAAYLIKLRQFDPLVFDDLMCGWVTRLLQSSSRPPLLQTLSVLVAGSCLQLDVIVQATLSVLRPQAKISNPATSEIAAQTLDILVNDGTNGLSLSPLELYSLKRKRKLFALKFVDKFVQLIRLSIQICAAASNPETKNRVRELILSPPVLEFLRGLATAQPDTLISDIVEPLSKTGETSLLQWLRVLIDHLLDDQENGGLFPPHPPPEPVAAVAYIGLDNTDLDPEVQVAHLIQYANDFSIGLCQLKMRIIFDAENKSTSSFRPSGDHTGGSENPLMKPFFQGIASTFKDRVTIWTDLVSVLNQECAYQVFHTHMLCNFVFDAKLLVQIRGYAEELVLNSPTFPPVRLCLGPLEPSLAEGRESGETLARALLSVIEATAYSIPKQGIASIATLLVDKLNMIIQSITLQEDELEKAEHVAVPEVFWNDSLTESRCWYVYLF
Length1449
PositionKinase
OrganismTuber melanosporum (strain Mel28) (Perigord black truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.08
Grand average of hydropathy-0.173
Instability index47.94
Isoelectric point8.74
Molecular weight162222.79
Publications
PubMed=20348908

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26164
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     364.50|     115|     128|      15|     140|       1
---------------------------------------------------------------------------
   15-  121 (145.78/117.78)	......................QAGP..QPWGNQPGQDAQnGlARS.SRLDIPNVVRP.PPARQP..PPDP....FLQPSHPRAVTEKPLIIDLTdsnPSHFqraLINTAKMDGVFNIPPVTPttiETPVVMEPVK..PYD
  122-  249 (181.81/112.69)	GALCSRSSIQNSRTRKRLKfapQACPpaSPQFIQPSKVYQ.G.AKS.S.LTPPALSRGnSSSRQKqiQPQPsksdFSKPNTRRDNKPKPYLLEVP...PGAM...MFPSSRCSDFFPWKGNHP...EDHVTDAQARngQYD
  272-  310 (36.91/13.49)	SALPSLSSLFLTVLDKRQK...........................yNRLTTPPTFKP.PP.RVT..LPD.......................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     292.47|      93|     128|     618|     713|       2
---------------------------------------------------------------------------
  618-  713 (151.00/107.09)	TSLRVGKHRIYI.VAGLLGCARRSGISVQDHMKSFLEGFGSNVKGSKDDVYLLVSELVRSKTFSVALYMK..W...LISRGILSeytITRESPCHVRLLAEV
  742-  840 (141.47/92.46)	TSLEVSKRILSSkIPAVFYGDLRAGGSVERFAPEELAYFGRLNRAVMYELGLWIRESVRKHVVKGAPVGRdnWrdlSVEVGITA...VRTEEFVMIRQLLEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.01|      37|      39|     375|     413|       3
---------------------------------------------------------------------------
  375-  413 (60.36/47.84)	KGVgsFAVGSETKWLKEWTIQVTRFLERTISECGSSS.DL
  417-  454 (61.65/41.88)	KMV..YAVRLSAHLFGENLLDRTLFLEWYLSYLETCSlDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     251.64|      86|     508|     478|     572|       4
---------------------------------------------------------------------------
  478-  572 (127.64/111.71)	RLAEALLGKAEAilAAEDKETYAPL......MQKL....SILLTDILFLHRESLIVSNSWESYRSILEACVdrrcsfVRSCLQ..NISQRNKNLLSPmQAR.QNDSVS
  985- 1083 (124.00/83.71)	RLFETIVSRMET..SFDDRESVGALsssaayLIKLrqfdPLVFDDLMCGWVTRLLQSSSRPPLLQTLSVLV......AGSCLQldVIVQATLSVLRP.QAKiSNPATS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26164 with Med12 domain of Kingdom Fungi
Unable to open file!