<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26158

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSFSPQNYESSSSTTKSTSPAHTAAQSANLASPPSSVAMQPHSVSQSTVTTSTSCPTPASSTSGLARDGSDGPGAIAASFADGKIPFETLGSDTKPLAHDHHNNEKSIDTQKPSSNDSNDHDPMDIDLKEGAGLSEEPSLESLQRDVGEAIGLCKSSYTSTLPVPKFDIVSLYGLGPIAASVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKQEPGAPGGLRNLMMWPDEEWYNQKVAGKEITIAEPDTAFYKQQLRAMKMEPGITPRNEYWEDVLGHEKSSKNAAEQLPKKPGSSSFKNTPQSNGTPAAQASSATVAPDPGRPKRAGRKRSYHDSSFVGYGEGFPDDDDLEGSLYSNDDDGGSVGKKKRKKMVRSSCMFIVLPVLGYLPFYTL
Length399
PositionHead
OrganismArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.06
Grand average of hydropathy-0.708
Instability index49.00
Isoelectric point6.27
Molecular weight42617.81
Publications
PubMed=21247460

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26158
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.50|      28|      29|      41|      68|       1
---------------------------------------------------------------------------
    5-   33 (38.38/19.84)	PQNYESSSSTTKSTSPAhTAAQSANLASP
   41-   68 (46.63/25.73)	PHSVSQSTVTTSTSCPT.PASSTSGLARD
   73-  100 (44.50/24.21)	PGAIAASFADGKIPFET.LGSDTKPLAHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.04|      33|      40|     123|     158|       2
---------------------------------------------------------------------------
  123-  158 (49.16/42.76)	PmDIDLKEGAGLSeePSLESLQR.D..VGEAIGLCKSSY
  165-  200 (48.88/31.12)	P.KFDIVSLYGLG..PIAASVARtDpvTGEKINRLRKSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      19|      32|     210|     233|       3
---------------------------------------------------------------------------
  210-  232 (30.34/33.87)	AGRN...............KPVKQEPG.APgglRNlMMW
  243-  277 (25.10/ 9.34)	AGKEitiaepdtafykqqlRAMKMEPGiTP...RN.EYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.18|      20|      32|     286|     305|       4
---------------------------------------------------------------------------
  286-  305 (34.55/17.89)	SSKNAAEQ..LPKKPG.SSSFKN
  318-  340 (26.62/12.25)	SSATVAPDpgRPKRAGrKRSYHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26158 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FETLGSDTKPLAHDHHNNEKSIDTQKPSSNDSNDHDPMDIDLKEGAGLSEEPSLESLQRD
2) MSFSPQNYESSSSTTKSTSPAHTAAQSANLASPPSSVAMQPHSVSQSTVTTSTSCPTPASSTSGLARDGSDGPGAIAASFADG
3) PRNEYWEDVLGHEKSSKNAAEQLPKKPGSSSFKNTPQSNGTPAAQASSATVAPDPGRPKRAGRKRSY
87
1
272
146
83
338










Molecular Recognition Features






MoRF SequenceStartStop




1) FVGYGEGFPDDDDLEGSLYS
343
362