<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26151
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNAEILAPLTSLEARLNALLASITSTPTASGAPAAAVSLLEADDALTSALQTLRTHQENYSKILRLRAEALSLEERVRETVRQVGELGDEISAAAGDDDDDSDEDSDDEAGGDIEMSEKGKDATRKNEVDYRLLLGFARRISKYNNEAAADASSARVLSKEPTGGDTAADTNGEVAKEDGIASGHGQTTGVGIAALPQDTVSWLDETANWTRLMSALPYPSEDRIRMGLMAHLHATAAAEGKDVEKEVEHILKAATQKDISKQETQPAGQGDQPQPDSDPGAGHPAGSGTAAINHQAGNSASHTAEPPKVKPKLDLDLYDPDDDDM |
Length | 326 |
Position | Middle |
Organism | Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
|
Aromaticity | 0.02 |
Grand average of hydropathy | -0.615 |
Instability index | 31.75 |
Isoelectric point | 4.45 |
Molecular weight | 34387.11 |
Publications | PubMed=21247460
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26151
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.73| 14| 15| 234| 247| 1
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234- 247 (23.25/15.40) HATAAAEGKDVEKE
250- 263 (23.49/15.63) HILKAATQKDISKQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.92| 14| 16| 138| 151| 2
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138- 151 (24.61/13.73) ARRISK..YNNEAAAD
155- 170 (19.31/ 9.47) ARVLSKepTGGDTAAD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 126.44| 41| 175| 95| 135| 3
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95- 135 (71.45/38.68) AGDDDD...DSDEDSDDEAG.GDIEMSEK.GKDATRKNE...VDYRLLL
268- 316 (54.99/28.11) AGQGDQpqpDSDPGAGHPAGsGTAAINHQaGNSASHTAEppkVKPKLDL
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|