<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26148

Description "RNA polymerase II mediator complex component Srb8, putative"
SequenceMTISHPPQMSNPYSQPPTGLSDQPTARMALQQQARPGPGSDLGRGPGPGTNASPVIDLTGSDNEDDEDLESSRPAKRLRIDTKGHDEIARILSSGMRLIQGASDDVNDGKSSEVTDPNIPFVESVRPPASFQDRLAYISVDGGGQQPQSSSSPLPLPPRPRRSLFMRDKSETAPEDDEQEDMTVQTTPYTMEKPAAAARLADNTVLDFHPWTGNHPEDALNEQTAKQGFYDRVQLSQNESNTARPSLYTHFKNPNGLKALSHIFAAALKRRQAMTKVTPNSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKNIPIGRAIWLAKCVGANEIRAFKRKGTAATIASGLEAKWVKDWTGSVQQFMESVVQSHEDAGWIENQAYAMRLSGRLFLEQLLDQDAYLEWFLGSLHASNLDMLPVWLSTIGVYWKNLTSYRKRGRRLAQTLLDKLAWALNVNRSAVLNPLITRLQSLIRSFITSYPSSFVLPLTWSQHQKALTACFNTSVPLETAILAQLIARNARLSKVSPQSAINSPQSIPRPAPQQLISLLDAPCASNGFPLLAAKCLALPLDHRTLIHSLLEWSSTPFRYGCARIYASARLLRRWRKLSIDTDAHISSFLAENSKYSARQLENAYHLVSELVRSQSFSVGKYLEWLMARGAVRSPDMSGQYLTADVELLRHLPSSRLPEHIWNLRNTLLSRAGVSVDAEAKQIRQIKTYLLQKHSDIFVGHVGTTDTEMMDGDIDWASLTWTVKSEISHWIREQVALKLRAQAQAQNQPSSNATAQAIASMIRPDQFYFLRCILERMGDVSILADVLKLLSQSSNPTVLASVTDTLNYHLPSFTAIGATMDLLQSFAISYSKLSKTEAHVQDLIVSLLDVAIVIPSEASTVAVLRRDLARYDKKSAMAASSPVSEHMADTLNPVNPTFGGMLDQLLASGNCMDDATLMRIFDLLIQKLETGKADISITSSEAARYLAQLRLFNPKTFDGLMIKRVVGMIRTSPRPKLSHFLPPLIGVGCITLPAFFGLVKRLLLDADKAGENNIPDLLHLRLDMLSVLGLGTTDQNTVPDLVFYRFKISRQEFVQKHCCIIVSAIRDAVMDASANHSAADASLHEQWNKAIFPLLCEIMVRHSSLARDECVKWVTAKFPTGLRLLNQTLDSLLGVESGNGNLEILPLPNGDDAGDANLHADPNRASTSSQSVQQQASDTIRRIDDFSLPFCLIKLQLLLAETDAAGKENVLDPIFSAAEMDVKKGLSRWVEIITVLDDEGKRQVSVEIFHIAKRHLLTILQLQQKAENKLLSLFITSASSSSTGNSDDGPAPHEFGLVYLRIIEELVSKEPNENDNISSAIGSALLERMNLLLQRIAFLSKAKPTDSGTTIMAQCNEGGMLGIWIYILLRLVALYRSSFDVERASKTDLSDQTRLLLSICYMAFTPALMQVLSHTTNLPPAPTGKYAHLQRTVPGNWNSLRIYTIDVANILVDTLPDEARIQCARFLRDRSPLFLQQQQDSRLLYLFGPMPDPQAGPISSSTSTTTSSAPPPGSSPLNTQGPTAQGSSAQPPHPTNPSIPTVEETTSPVQNFRFQQGNRVVGPCPPRTWEMIEESAPVVGRPSLQGDITPTFSFLLFSLKYFNVFISFHEICEHLLGYQFASPISDCTILLTSYAIFNISSLPIFTSYIFLTNNNEHLLLLLVWSSLSGERMDGRRILFFFIALYFSIIPVCITDCIYYRTSEIETVSAC
Length1758
PositionKinase
OrganismArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.07
Grand average of hydropathy-0.158
Instability index47.64
Isoelectric point6.98
Molecular weight194685.31
Publications
PubMed=21247460

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26148
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.25|      17|      18|    1555|    1571|       1
---------------------------------------------------------------------------
    4-   18 (27.89/12.29)	.SHPPQMSNPY.SQPPT
 1555- 1571 (35.05/17.56)	SSAPPPGSSPLNTQGPT
 1575- 1589 (31.31/14.81)	SSAQPP..HPTNPSIPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.55|      20|      20|     655|     674|       2
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  426-  451 (26.41/14.45)	LGSLHASNLDMlpvwlsTIGVYW....KNL
  655-  674 (34.39/21.17)	LVSELVRSQSF......SVGKYL....EWL
  675-  697 (27.76/15.59)	MARGAVRSPDM......S.GQYLtadvELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     427.81|     118|     600|     796|     915|       3
---------------------------------------------------------------------------
  796-  913 (179.24/129.44)	..QPSSNA.TAQAIASMI....RPDQFYFLRCILERMGDVSILA..DVLKLLSQSSNPTVLASVTDTLNYHLPSFTAIG.ATMD..LLQS.FAISYSKLSKTEaHVQD...LIVSLL.....DVAIVIPSEASTVAVLR
  914-  998 (108.40/72.27)	R...............................DLARYDKKSAMA..........ASSP.VSEHMADTLNPVNPTF...G.GMLD.qLLASgNCMDDATLMR....IFD...LLIQKLetgkaDISITSSEAARYLAQLR
 1000- 1127 (140.17/100.80)	FnPKTFDGlMIKRVVGMIrtspRPKLSHFLPPLI.GVGCITLPAffGLVKRLLLDADKAGENNIPDLLHLRLDMLSVLGlGTTDqnTVPD.LVFYRFKISRQE.FVQKhccIIVSAI.....RDAVMDASANHSAA...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.97|      10|      20|     188|     197|       5
---------------------------------------------------------------------------
  188-  197 (19.12/ 9.72)	PYTMEKPAAA
  210-  219 (21.85/12.18)	PWTGNHPEDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.76|      12|      15|     318|     332|       6
---------------------------------------------------------------------------
  325-  339 (18.45/11.07)	ILLDQCLGkniPIG.R
  341-  353 (18.31/ 6.23)	IWLAKCVG...ANEiR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.49|      12|      21|     364|     375|       7
---------------------------------------------------------------------------
  364-  375 (20.31/14.47)	IASGLEAKWVKD
  388-  399 (22.18/16.62)	VQSHEDAGWIEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.12|      44|    1038|     111|     157|       8
---------------------------------------------------------------------------
  111-  157 (69.42/49.30)	SSEVTDPNIPFVeSVRPPASFqdRLAYISVDG..GGQQPQSSSSPLPLP
 1151- 1196 (71.70/40.91)	SSLARDECVKWV.TAKFPTGL..RLLNQTLDSllGVESGNGNLEILPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.11|      22|      26|     478|     500|       9
---------------------------------------------------------------------------
  478-  500 (34.59/21.41)	SAVLNPLiTRLQ...SLIRSFITSYP
  501-  525 (36.52/18.56)	SSFVLPL.TWSQhqkALTACFNTSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.13|      12|      16|    1493|    1504|      10
---------------------------------------------------------------------------
 1493- 1504 (20.22/13.39)	IDVANILVDTLP
 1509- 1520 (22.91/16.35)	IQCARFLRDRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.73|      22|      26|    1315|    1336|      12
---------------------------------------------------------------------------
 1315- 1336 (35.08/22.21)	ENKLLSLFITSASSSSTGNSDD
 1342- 1363 (36.64/23.54)	EFGLVYLRIIEELVSKEPNEND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.58|      15|      26|    1592|    1606|      13
---------------------------------------------------------------------------
 1592- 1606 (27.46/17.86)	ETTSPVQNFRFQQGN
 1621- 1635 (26.11/16.57)	EESAPVVGRPSLQGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26148 with Med12 domain of Kingdom Fungi
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