<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26141

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQLTLISNQDELSTCHWKVYGVDSNGSDLGTSGASVNQLFKKIQICALALREAGCLTCPSSDGTGIWVFSLDTEFSRLKSFASNQSEDAEGLIVGQVPIYAELSQKLLSKASENSRNSSLAENLSRRNKLEIPASLELTHSSLYASFISSIAWSLSLHLTKRYRAIPLGKRTFFTAADPDMSPGGASASILSTLDIELSQSGKVVISLRSRSQPGISQLSEGPVVSSIGELRLHDDIWLAPTGTIARYIGIGGSEYALGTGNSYHSNIHGSRNGFSGEVQDPWKLAVCSWLERTGVPIGISDNMRWVQVEVVTRHQRLGQGKATGTRRIYWPAQLCFKKSRFPTGSPIQGAETLSRDSLGPLQYARQWLKCSVPRDEVLSRNAASDVAQHPEQHPQSETLASPDGIDIPNTTESMARALVYPDFHPATVYPTPPGGALGLGQLSSDHSGGQYPLELPHISREDPDANITESLNPNTRSLLEATSPGLGAGTGMYDTADDDLFEEMDDNFDNKGITEADFNFFDEPGLSDTNLDVDSGNPSHNFVISDHPTAESKPDLEMSESLASLEPAPPTEPHRMQTPMLNNAVEEGTDQGHSGIKSSEPTTREADTHRNTERPISPPLSPSGVKRILFSSPKGNSEKPKNTITPATNLPVEASSQPGQHKGRYDAISFQHELDFSDRKYGIDGRFWFLPDHKTFNHNADSHTTKIPMVNDPSVPFYKLGQQTYPHKINERLDSADSERCSSSTSSTSSVSGNHYEQAGFNKMRPVDPIDNRLRRGDLEEIFSVSSSLQSPGFNVRKPYTTHSDLEEDVLLAGLVYPATDWLLSSYFTAFEPSIRSALCGRDETLHVAQLLVDQITQSTLTHKTEITYEENEKDIWQASIDDINALGQSRRPSLKCYASISDIGPSQQIKDTTGGAIINLRPPHMQIRRGNCSLEVLPTAISFWETFGLEPLKGKKDIISYCLHPVSMQESANAFLDRLGLTYLGANLGTFARHGNAKGLVPWSLSQDKLDYTSIMRKLLHICESLGTALSNLSMNNKTVVVYIINPFRIGAAMVDICVAFLRLFRKYVEEADKRSVRRLNELVLQIVPSDFITGDDSLVIPTQNDYLRLALEVYSRCPPQDPISDMFAGAPAFTLATSVPKMIPFRLTSEEGSPMDAGQACHVAYSVSQDQRWVTAAWCDNLGLRQLTLSYSLRQDVSHTCRPLAEVREDIWQVTVDMTGMSRCRWRVVLAKDEPMDAEEITEPNLHLKLPPPPPQLNALYQSGNMSTPVSTPKPSISSPDPSTSAPTPPNIANTTNFSSEPSQPQVQSHFQVHPTQISVETNTETLLVDKSDDSWALVLSQRLNNSHSFTNYKPALANGYLIHRSGTSDTDWKASLMVNLIHLQSRIPPSIVLKDLLSIFRDMSSLTRTRGLVCSRGNNGLPWHISTAIKGQELLGCIL
Length1443
PositionKinase
OrganismArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.07
Grand average of hydropathy-0.397
Instability index48.79
Isoelectric point5.56
Molecular weight158688.18
Publications
PubMed=21247460

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26141
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.93|      42|      49|    1245|    1286|       1
---------------------------------------------------------------------------
  422-  467 (47.97/21.57)	..PDF....HpATVYPTPPggalglgQLSSDHS..GGQY..PLELPHISREDPDAN
 1245- 1286 (74.15/37.62)	TEPNL....H.LKLPPPPP.......QLNALYQ..SGNMSTPVSTPKPSISSPDPS
 1291- 1338 (55.80/26.37)	TPPNIanttN.FSSEPSQP.......QVQSHFQvhPTQISVETNTETLLVDKSDDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     181.82|      49|      49|     249|     297|       2
---------------------------------------------------------------------------
  212-  244 (23.80/ 9.05)	........................SQPGISQLSEGPvvssigeLRLHDDIWLAP..TGT
  248-  296 (87.65/53.89)	YIGIGGS.EYALGTGNSYHSNIHGSRNGFSGEVQDP.......WKLAVCSWLER..TGV
  297-  346 (70.37/41.76)	PIGISDNmRWVQVEVVTRHQRLGQGKA..TGTRRIY.......WPAQLCFKKSRfpTGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.69|      44|      50|     534|     582|       3
---------------------------------------------------------------------------
  534-  577 (76.42/36.74)	VDSG.NPSHNFVISDHPTAESKPDLEMSESLASLEPAPPTEPHRM
  586-  629 (65.96/36.90)	VEEGtDQGHSGIKSSEPTTREADTHRNTERPIS.PPLSPSGVKRI
  632-  659 (31.31/10.80)	...S.SPKGN...SEKPKNTITPATNLPVE.ASSQP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.40|      24|     273|      97|     137|      10
---------------------------------------------------------------------------
   70-  101 (29.64/41.02)	SLDTEFSRlksfaSNQSEDAEGLIvgqVPIYA
  119-  145 (33.75/11.14)	SLAENLSR.....RNKLEIPASLElthSSLYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.96|      25|     162|     986|    1011|      12
---------------------------------------------------------------------------
  986- 1011 (41.44/26.30)	LGANLGTFARHGNAKGlVPWSLSQDK
 1150- 1174 (45.53/25.01)	LTSEEGSPMDAGQACH.VAYSVSQDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.91|      51|     335|     836|     898|      13
---------------------------------------------------------------------------
  836-  898 (64.35/61.63)	IRSALCgrdETLHVAQLLVDQITQSTLTHKTEITYEENEkDIWQASIdDINalGQSRrpslkC
 1177- 1227 (93.56/50.86)	VTAAWC...DNLGLRQLTLSYSLRQDVSHTCRPLAEVRE.DIWQVTV.DMT..GMSR.....C
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26141 with Med13 domain of Kingdom Fungi
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