<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26138
Description |
Mediator of RNA polymerase II transcription subunit 20 |
Sequence | MDNDRSSLLLRVYYIPSNPELPTTATRTVIDRFKAIHQPARLGRWALEFKLVRDTASCLPAANFPHNKVPTPRYMHILSLSHYQNHGFVRISPRPEVDPLDPAEIEKQMNSPPPVPIPATGVSSQSKPSADSKDLNSPSQNEAHTTAIKTFDPQSYLSFFSMTTKFFQPLWNHRYTVVVTSGEAYEVGDFRVRIGEVRQTMPRPRLRGAIVEIEYRGPGQRQSEPDLTREPEEDWYFAPPLPHYPPREVIIPTDEDWELGVMLIRELWDNFSIPGASESIQVPGLGLERREYFDKGGASAHTARKKASLVGVDLARQYMDVFKFYR |
Length | 326 |
Position | Head |
Organism | Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.558 |
Instability index | 58.28 |
Isoelectric point | 6.77 |
Molecular weight | 37191.66 |
Publications | PubMed=21247460
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364152
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26138
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.96| 18| 20| 218| 235| 2
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218- 235 (34.44/16.87) PGQRQSEP.DLTREPEEDW
239- 257 (32.52/15.55) PPLPHYPPrEVIIPTDEDW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.03| 14| 24| 265| 287| 3
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260- 277 (18.74/29.79) GVML.iRELWDnfsIPGAS
284- 299 (22.28/ 7.40) GLGLerREYFD...KGGAS
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