<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26132

Description Mediator complex subunit 26
SequenceMTAAPASPQQMRDRLLQAIDSQSNIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLIEPVHQNEVALRALAGAAGSANGGAHNCRPELGVAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQVPSPLPLAQPPTPPVRRLDLLPNAESPVHWPEQPEGHPRLTGPACRAGLSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQLPRTELEQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWPGVNGCEDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length588
PositionUnknown
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.03
Grand average of hydropathy-0.862
Instability index64.76
Isoelectric point9.35
Molecular weight64460.76
Publications
PubMed=15057822

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISO:RGD

GO - Biological Function
transcription coregulator activity	GO:0003712	ISO:RGD

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26132
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     465.86|      81|      84|     232|     312|       1
---------------------------------------------------------------------------
  113-  185 (84.36/34.00)	.P.ELGVAGAP...KSIHDLK..NRNDiqRL.PGQRLDRlGSRK.....R..RGDQRDLGHP.......G..........PP.......HKVSKGSPDPlvpnaSPLP.........TNGI
  191-  231 (61.51/22.48)	S...LP..............SPLD.GS..GH.LGP...D.GS.R.....L..ELS.ENEKH...............STKI..........PVNAVRPRP.....S................
  232-  312 (152.30/68.26)	SP.GLGKPPVPCLQTKAAQLQPLDRAD..EP.PGPPYPR.GSPR.....C..SISPRNSRHE.......GSFARHRSSYIPK.......GPVSSPSPRP.....QPLD.........TTQV
  314-  422 (86.22/34.94)	SPlPLAQPPTPPVR....RLDLLPNAE..SPvHWPEQPE.GHPRltgpaCraGLSPDSSKADsdaassgGSDSKKKKRYRPRdytvnldGQVAEAGVKP.....VRLKerkltfdpmTRQI
  429-  493 (81.48/32.55)	EP.VRADSPVPTEQLPRTELEQ.QEAK..AS.LQSPFEQ.TNWK........ELS.RNEIIQ.......SYLSR.QSSLLSS.......SGAQTP..........................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26132 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWP
2) LRALAGAAGSANGGAHNCRPELGVAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQVPSPLPLAQPPTPPVRRLDLLPNAESPVHWPEQPEGHPRLTGPACRAGLSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQLPRTELEQQEAKASLQSPFEQTNW
495
94
549
465










Molecular Recognition Features






MoRF SequenceStartStop




1) RLDLL
2) RLKERKL
3) SKKKKRYRPRDYTVNLDGQV
328
407
379
332
413
398