<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26131

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDTDDNSNCTGQNEQQRESSGHRRDQIIEKDAALCVLIDEMNERP
Length233
PositionMiddle
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.04
Grand average of hydropathy-0.736
Instability index51.63
Isoelectric point5.42
Molecular weight27238.93
Publications
PubMed=15057822
PubMed=15632090

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.
ECO:0000256	RuleBase:RU364060
GO - Cellular Component
mediator complex	GO:0016592	ISO:RGD
nuclear body	GO:0016604	IEA:Ensembl
transcription regulator complex	GO:0005667	ISO:RGD
ubiquitin ligase complex	GO:0000151	IDA:RGD
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
protein ubiquitination	GO:0016567	IDA:RGD
regulation of transcription by RNA polymerase II	GO:0006357	ISO:RGD
stem cell population maintenance	GO:0019827	ISO:RGD

Interaction

Binary Interactions

Repeat regions

Repeats

>MDP26131
No repeats found




Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP26131 with Med7 domain of Kingdom Metazoa

Intrinsically Disordered Regions

IDR SequenceStartStop
1) LPHSEAGMRVKTEPMDTDDNSNCTGQNEQQRESSGHRRD
175
213

Molecular Recognition Features

MoRF SequenceStartStop
1) PMQYIKEYTD
14
23