<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26126

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSLLDRLHAKFNQSRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNATPLDKILHGSVGYLTPRSGGHLMNMKYYASPSDLLHDTTASPITLHEKNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPADNKWTPSFSAVTSANSVDLPACFFLKFPQPIPVSKAFVQKLQNCTGIPLFETPPTYLPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGQSLQGTLVSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKNKSSRVPPDKPKHQTEDDFQRELFSMDVDSQNPMFDVSMTADALDTPHITPAPSQCSTPPTTYPQPVSHPQPSIQRMGRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGMPMLGGDNGESKLKGSSQADTVDFSILSVAGKALGAADLLEHHSGSQSPLLTTGELGKEKTQKRVKEGNGMGASSGSGPGSDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSNRPFTPPTSTGGSKSPGSSGRCQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYSSSGSVSSSGSKSHHSHSSSSSSLSSASTSGKMKSSKSEGSSSAKLSGSMYSSQGSSGSSQSKNSSQTGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSISKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGSSHVSGTSSSSGMKSSSGSGSSGSLSQKTPPASNSCTPSSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPIDSQMGASTNSSNHPMSSKHNMSGGEFQSKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGDSGGEGLRPQIASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNVDSESESGSSIAERSYQNSPSSDDGVRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQTSSMTNNPILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1567
PositionMiddle
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.04
Grand average of hydropathy-0.672
Instability index53.43
Isoelectric point8.88
Molecular weight166408.81
Publications
PubMed=15057822
PubMed=15632090
PubMed=22673903

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
chromatin	GO:0000785	IDA:RGD
mediator complex	GO:0016592	ISS:UniProtKB
nucleolus	GO:0005730	ISS:UniProtKB
nucleoplasm	GO:0005654	IEA:Ensembl
nucleus	GO:0005634	IDA:RGD
protein-DNA complex	GO:0032993	IDA:RGD
ubiquitin ligase complex	GO:0000151	IDA:RGD

GO - Biological Function
chromatin binding	GO:0003682	IDA:RGD
chromatin DNA binding	GO:0031490	IDA:RGD
DNA binding	GO:0003677	ISO:RGD
estrogen receptor binding	GO:0030331	ISO:RGD
LBD domain binding	GO:0050693	ISO:RGD
nuclear hormone receptor binding	GO:0035257	ISO:RGD
nuclear receptor binding	GO:0016922	ISO:RGD
nuclear receptor coactivator activity	GO:0030374	ISS:UniProtKB
peroxisome proliferator activated receptor binding	GO:0042975	ISO:RGD
promoter-specific chromatin binding	GO:1990841	ISO:RGD
protein-containing complex binding	GO:0044877	IDA:RGD
retinoic acid receptor binding	GO:0042974	ISO:RGD
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IDA:RGD
thyroid hormone receptor binding	GO:0046966	IDA:RGD
transcription coactivator activity	GO:0003713	ISS:UniProtKB
transcription coregulator activity	GO:0003712	IDA:RGD
transcription corepressor activity	GO:0003714	ISS:UniProtKB
transcription factor binding	GO:0008134	ISO:RGD
vitamin D receptor binding	GO:0042809	IDA:RGD

GO - Biological Process
androgen biosynthetic process	GO:0006702	ISS:UniProtKB
angiogenesis	GO:0001525	ISS:UniProtKB
animal organ morphogenesis	GO:0009887	ISO:RGD
animal organ regeneration	GO:0031100	ISO:RGD
brain development	GO:0007420	IERGD
camera-type eye development	GO:0043010	ISO:RGD
cell morphogenesis	GO:0000902	ISS:UniProtKB
cellular response to epidermal growth factor stimulus	GO:0071364	ISS:UniProtKB
cellular response to hepatocyte growth factor stimulus	GO:0035729	ISO:RGD
cellular response to steroid hormone stimulus	GO:0071383	ISO:RGD
cellular response to thyroid hormone stimulus	GO:0097067	IDA:RGD
embryonic heart tube development	GO:0035050	ISO:RGD
embryonic hemopoiesis	GO:0035162	ISO:RGD
embryonic hindlimb morphogenesis	GO:0035116	ISO:RGD
embryonic placenta development	GO:0001892	ISO:RGD
enucleate erythrocyte development	GO:0048822	ISO:RGD
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	ISO:RGD
erythrocyte development	GO:0048821	ISS:UniProtKB
fat cell differentiation	GO:0045444	ISO:RGD
heart development	GO:0007507	ISO:RGD
in utero embryonic development	GO:0001701	ISO:RGD
intracellular steroid hormone receptor signaling pathway	GO:0030518	ISS:UniProtKB
keratinocyte differentiation	GO:0030216	ISS:UniProtKB
lactation	GO:0007595	ISO:RGD
lens development in camera-type eye	GO:0002088	ISS:UniProtKB
liver development	GO:0001889	ISO:RGD
mammary gland branching involved in pregnancy	GO:0060745	ISO:RGD
mammary gland branching involved in thelarche	GO:0060744	ISO:RGD
mammary gland epithelial cell proliferation	GO:0033598	ISO:RGD
megakaryocyte development	GO:0035855	ISS:UniProtKB
monocyte differentiation	GO:0030224	ISO:RGD
mRNA transcription by RNA polymerase II	GO:0042789	ISS:UniProtKB
multicellular organism development	GO:0007275	ISO:RGD
negative regulation of apoptotic process	GO:0043066	ISS:UniProtKB
negative regulation of keratinocyte proliferation	GO:0010839	ISS:UniProtKB
negative regulation of neuron differentiation	GO:0045665	ISS:UniProtKB
negative regulation of transcription by RNA polymerase II	GO:0000122	ISS:UniProtKB
peroxisome proliferator activated receptor signaling pathway	GO:0035357	ISO:RGD
positive regulation of cell population proliferation	GO:0008284	ISO:RGD
positive regulation of erythrocyte differentiation	GO:0045648	ISO:RGD
positive regulation of G0 to G1 transition	GO:0070318	ISO:RGD
positive regulation of gene expression	GO:0010628	ISS:UniProtKB
positive regulation of hepatocyte proliferation	GO:2000347	ISO:RGD
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	ISO:RGD
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	ISO:RGD
positive regulation of keratinocyte differentiation	GO:0045618	ISS:UniProtKB
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:RGD
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISS:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
protein import into nucleus	GO:0006606	ISO:RGD
protein ubiquitination	GO:0016567	IDA:RGD
regulation of RNA biosynthetic process	GO:2001141	ISO:RGD
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription, DNA-templated	GO:0006355	ISO:RGD
regulation of vitamin D receptor signaling pathway	GO:0070562	ISO:RGD
retinal pigment epithelium development	GO:0003406	ISO:RGD
thyroid hormone generation	GO:0006590	ISO:RGD
thyroid hormone mediated signaling pathway	GO:0002154	ISS:UniProtKB
ventricular trabecula myocardium morphogenesis	GO:0003222	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26126
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     959.79|     100|     100|    1034|    1133|       1
---------------------------------------------------------------------------
  520-  597 (53.32/ 8.20)	............................................MVK.KnlpPASSP............GY.......G.mTTGSNPMSGTTTPTNtfPGG.PITTLFN.MSMSIKDRhESVGHGEDF..SK........V.........SQNPILTSLLQ..IT....G
  607-  712 (87.93/18.60)	P...TP....P....HHTPPPV.................SS...MAG.N...TKNHPmlmnllkdnpaqDF.......S.....TLYGSSPLERQN..SSS.GSPRMEM.CSGSNKTK.KNKSSRVPP..DKpkhqteddFQ..R.ELFSMD.....VDSQ..NPmfdvS
  713-  809 (101.80/22.77)	M...TA....D....ALDTPHI.TPAPS.......QCSTPPT..TYP.Q...PVSHP............QP.......SiqRMGRLSSSDSIG......PD.VTDILSDiAEEASKLP.ST....SDD..CP........PI..G.TPVRDSSSSGHSQSAlfDS....D
  812-  909 (91.39/19.64)	Q...TN....N....N..ENPY.TD............PADLIadAAG.S...PSSDS.........ptnHF.......F..PDGVDFNPDLLNSQS..QSGfGEEYFDE.SSQSGDND.DFK..GFAS..QA........LN..TlGMPMLGGDNGESKLK..GS....S
  910- 1030 (95.65/20.92)	Q.adTV....DfsilSVAGKAL.GAADLlehhsgsQSPLLTT.gELG.K...EKTQK............RVkegngmgA..SSGSGPGSDSKPGKR..SRT.PSNDGKS.KDKPPKRK.KADTEGKSP..SH........SS..N.RPFTPPTSTGGSKSP..GS....S
 1034- 1133 (168.16/42.71)	Q...TP....P....GVATPPI.PKITI.......QIPKGTV..MVG.K...PSSHS............QY.......S..SSGSVSSSGSKSHHS..HSS.SSSSLSS.ASTSGKMK.SSKSEGSSS..AK........LS..G.SMYSSQGSSGSSQSK..NS....S
 1134- 1188 (72.13/13.85)	Q...TG..gkP....G..SSP...............ITK................H...........................G..............LSS.GSSS........TKM....KPQGKPS..SL........MN..P.SISKPNISPSHSRPP..GG....S
 1192- 1282 (111.50/25.69)	A...SPmkpvP....G..TPPS.SK............AKSPI..SSG.S...GSSH.........................VSGTSSSSGMKS.SS..GSG.SSGSLSQ.KTPPAS...NSCTPSSSS..FS........SS..GsSMSSSQNQHGSSKGK..SP....S
 1285- 1371 (92.67/20.03)	K...KP....S......LTAVI.DKL...........KHGVV..TSG.....P..............................GGEDPIDSQMGAS..TNS.SNHPMSSkHNMSGGEF.QSKREKSDKdkSK........VS..T.SGGSVDSSKKTSESK..NV....G
 1377- 1471 (85.23/17.79)	KiiiSK....H....DGGSPSIkAKVTL.......QKPGDSG..GEGlR...PQIAS............S........K..NYGSPLISGSTPKHE..RGS.PSHSKSP.AYTPQNVD.SESESGSSI..AE........RSyqN.SPSSDDG.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.12|      44|     340|      86|     135|       2
---------------------------------------------------------------------------
   86-  135 (67.78/59.67)	CYITSDMFYVEVQlDPAGQ..LC...DVKVAHHgenpVSCpELVQQLREK..NFDEF
  428-  478 (68.34/40.90)	CPLSESRFSVSFQ.HPVNDslVCvvmDVQDSTH....VSC.KLYKGLSDAliCTDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.55|      15|      41|     283|     297|       4
---------------------------------------------------------------------------
  283-  297 (31.39/19.22)	DLPACFFL.KFPQPIP
  326-  341 (24.16/12.92)	ELITQFELsKDPDPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.03|      31|      48|     137|     168|       6
---------------------------------------------------------------------------
  137-  168 (49.78/27.55)	KHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
  187-  219 (53.25/26.06)	KILHGSVG.YLTPrsGGHLMNMKYYASPSDLLHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.52|      12|      15|    1481|    1492|       7
---------------------------------------------------------------------------
 1481- 1492 (19.60/13.52)	EKHKKHKKEKKK
 1499- 1510 (19.91/13.86)	DRDRDKDRDKKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26126 with Med1 domain of Kingdom Metazoa
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