<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26125

Description WD repeat and HMG-box DNA binding protein 1 (Predicted)
SequenceMPAIQKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNGKLVTAVSNNTVQVYTFPEGAPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKVVDVMDNSQQQTFRGHDAPVLSLSFDPKDVFLASASCDGTVRVWNISDQTCAASWPVLRKSNDVVNSESICRLAWQPKTGKFLAVPVEKSVKLYRRETWSNPFDLSDSSVTQTLNIVTWSPCGQYLAAGAINGLIVVWNVETKECMERVKHEKGYAICGLAWHPTYSRICYTDVEGNLGILENVCDLSGKLSSNKVPSGVEKDYSDLFDGDDTSSAGDFLNDNAVEIPSFSKGIRNEEDDNDDLMLAADHVLGDDENSVDVTMLRNDLHREEGEDRQASSLHSLPLVKSQRPLYDGPMPTPRQKPFQPSSTPLHLTHRFMAWNSVGIIRCYNDDQDSAIDVEFHDTSIHHATHLSNAFNYTMGSLSHEAVLLACESADELASKLHCLHFSSWDSSKEWIVDMPENEDIEAICLGLGWAAAATSALLLRLFTIGGVQKEVFCLPGPVVSMAGHGEQLCIVYHRGTGFDGDQCLGVQLLELGRKKKQVLHGDPLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILPFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAENGYDYEESIKKQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAEIQTEEREEDFRERLNAGYSHTTTEWSQPRVRSQVEEDAEDREDTVSEGNPEPQNHGQNLIQSANSSDTPAMKSGAVFSSSQGRVNPFKVLVSSKEPAVSVNATRSANILDNMNKLSRKSTSFNRVANNEKSPVIKPLIPKPRCKQASAASYFQKRTSQAEKTEEVKENPKSSSSEAPAVCLQNSEVQRPKTGFQMWLEENRSHIMSDNPDISDEADIIKEGMIRFRVLSAEERKEWTNKAKGGTASDGAEAKKRKRGVSEICETEKQEEAVKENLELSKKQKALDLSTNQKLSAFAFKQE
Length1117
PositionTail
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.07
Grand average of hydropathy-0.502
Instability index39.01
Isoelectric point5.40
Molecular weight124247.15
Publications
PubMed=15057822
PubMed=15632090

Function

Annotated function 
GO - Cellular Component
chromosome, centromeric region	GO:0000775	ISO:RGD
nuclear replication fork	GO:0043596	IBA:GO_Central
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
chromatin binding	GO:0003682	ISO:RGD
RNA binding	GO:0003723	ISO:RGD
RNA polymerase binding	GO:0070063	ISO:RGD

GO - Biological Process
DNA repair	GO:0006281	IBA:GO_Central
DNA-dependent DNA replication	GO:0006261	IBA:GO_Central
heterochromatin maintenance	GO:0070829	ISO:RGD
mitotic cell cycle	GO:0000278	IBA:GO_Central
regulation of chromosome organization	GO:0033044	ISO:RGD
RNA processing	GO:0006396	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26125
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     700.52|     236|     294|     241|     506|       1
---------------------------------------------------------------------------
  241-  500 (363.02/238.90)	C.GQYLAAGAINGLIV....VWNVEtKE..CM..ERVKHE.KGYAICgLAWHptysRICYTDVEGNLGIleNVCDLSGK....LSSNKVPSgVEKDY.SDL.FDGDDTSSAGDflNDNAVEIpsFSKGIRNE....EDDNDDLMLAADH..VLGDDENSVDVTMLRNDLHR.EEGEDRQASSLHSLPLVKSQRPLYDGPMptprQKPFQpSSTPLHLTHRFMAWNSVGiircYNDD.QDSAI..D....................VEFHDTSIHHATHLsnAFNYTMGS....LSHEAVLLACESADELA
  531-  816 (337.50/163.64)	ClGLGWAAAATSALLLrlftIGGVQ.KEvfCLpgPVVSMAgHGEQLC.IVYH....RGTGFDGDQCLGV..QLLELGRKkkqvLHGDPLPL.TRKSYlTWLgFSAEGTPCYVD..SEGCVRM..LNRGLGNTwtpvCNIREHCKGKSDHywVVGIHENPQQLRCIPCKGSRfPPTLPRPAVAILPFKLPYCQTSTEKGQM....EEQFW.HSVLFHNYLDYLAENGYD....YEESiKKQAVkeQqellmkmlalscklerefrcVELADLMTQNAVHL..AIKYASRSrkliLAQKLSELAAEKAAELA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.25|      44|      70|     911|     955|       2
---------------------------------------------------------------------------
  911-  955 (66.66/55.99)	KEPAVSVNATRSANILDNmNKLSRKSTSFNRVANNEKSPVI..KPLI
  983- 1028 (73.59/56.24)	KENPKSSSSEAPAVCLQN.SEVQRPKTGFQMWLEENRSHIMsdNPDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.92|      42|      82|       9|      79|       3
---------------------------------------------------------------------------
    9-   50 (77.63/35.99)	RYGHTEGHTEVCFDDSGSFIVTCGSDGDVRMWEDLDDDDPKS
   92-  131 (64.78/67.97)	RFTTNANH..VVFNGDGTKIAAGSSDFLVKVVDVMDNSQQQT
  133-  164 (48.51/15.61)	R.GHDAPVLSLSFDPKDVFLASASCDGTVRVWN.........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26125 with Med16 domain of Kingdom Metazoa
Unable to open file!