<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26124

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPADVSQDPRHMVLVRGLVLPVGGSSAPGPLQPKQAVPLPPAPTSAATLSAAPQQTLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGPGLAAPAQPGAPSMQAGTVTPGGVSGPSPAQLGGPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGTTQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPALLPPHQSLGQPQLGPQLLHPPPTQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length746
PositionUnknown
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.05
Grand average of hydropathy-0.229
Instability index57.26
Isoelectric point8.72
Molecular weight78119.73
Publications
PubMed=15057822

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	IEA:Ensembl
transcription regulator complex	GO:0005667	ISO:RGD

GO - Biological Function
retinoic acid receptor binding	GO:0042974	ISO:RGD
retinoid X receptor binding	GO:0046965	ISO:RGD
transcription coactivator binding	GO:0001223	ISO:RGD
transcription factor binding	GO:0008134	ISO:RGD

GO - Biological Process
negative regulation of fibroblast proliferation	GO:0048147	ISO:RGD
negative regulation of transcription by RNA polymerase II	GO:0000122	ISO:RGD
positive regulation of cell cycle arrest	GO:0071158	ISO:RGD
positive regulation of chromatin binding	GO:0035563	ISO:RGD
positive regulation of mediator complex assembly	GO:2001178	ISO:RGD
positive regulation of transcription by RNA polymerase II	GO:0045944	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26124
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     493.53|      59|      60|     614|     672|       1
---------------------------------------------------------------------------
  185-  241 (47.36/ 7.85)	..........P......RKLPALRLLFEKAAPP.............ALLEPLQP......PADVSQ.D..P.RHmvlvrglvlpvggsSAPGPlQP
  242-  299 (42.73/ 6.29)	KQAVP.LPPAPtsaatlSAAPQ...QTLPPVPPQYQVP........GNLSAAQV..aaqnAVEAAK.N..QkAG..............L.......
  300-  340 (62.64/12.98)	.GPRF.SPINP................LQQAA..SGVG...PPfsQAPAPPLA...........P..G..P.PG...............APKP.PP
  342-  382 (55.43/10.56)	SQPSLvSTVAP......G..P...GL...AAPAQPGAP...SM..QAG....................tvT.PG..............GVSGP.SP
  538-  579 (44.24/ 6.80)	......................IRQVITNHKQVQQQKL...EQ..QRGMGAQQA......PPG..L.G..P.IL..............EDQAR.PP
  580-  630 (86.03/20.84)	QN.LL.QLRAP......QPQPQGAV....GASAATGQP...QP..QGTT...QA......PTGAPQ.G..P.PG..............AAPGP.PP
  631-  689 (105.32/27.32)	SGPIL.RPQNP......GANPQLRSLLLNPAPPQTGVP...PP..QASLHHLQP......P.GAPAlL..P.PH..............QSLGQ.PQ
  690-  734 (49.78/ 8.66)	LGP......................QLLHP.PPTQSWPtqlPQ..RA......PlpgqmlLSGGPR.G..PvP................QPGL.QP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.92|      30|     111|      39|      69|       2
---------------------------------------------------------------------------
   39-   69 (53.43/37.49)	YLLPAIEYFN.GGPPAETdFGGDYG..GTQYSLV
  151-  183 (44.49/25.82)	YLLPAVESTTySGCTTES.LVQKIGerGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.55|      19|      24|     459|     477|       3
---------------------------------------------------------------------------
  459-  477 (35.86/28.01)	LTTLGPLFR...N..SRMVQFHFT
  481-  504 (26.69/18.70)	LESLKGLYRimgNgfAGCVHFPHT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26124 with Med25 domain of Kingdom Metazoa
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