<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26122

Description Mediator complex subunit 30
SequenceMSTPPLAPTGMASGPFGGPQAQQAAREVNTATLCRIGQETVQDIVYRTMEIFQLLRNMQLPNGVTYHTGTYQDRLTKLQDHLRQLSILFRKLRLVYDKCNENCGGMDPIPVEKLKQKNQQLKQIMDQLRNLIWDINAMLAMRN
Length143
PositionHead
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.06
Grand average of hydropathy-0.457
Instability index38.42
Isoelectric point9.33
Molecular weight16345.82
Publications
PubMed=15057822
PubMed=15632090

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	ISO:RGD
nucleus	GO:0005634	ISO:RGD
ubiquitin ligase complex	GO:0000151	IDA:RGD

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	ISO:RGD
transcription coactivator activity	GO:0003713	ISO:RGD
transcription coregulator activity	GO:0003712	ISO:RGD

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:RGD
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
protein ubiquitination	GO:0016567	IDA:RGD
stem cell population maintenance	GO:0019827	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26122
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.93|      29|      34|      69|      97|       1
---------------------------------------------------------------------------
   69-   97 (49.02/29.94)	GTYQD.RLTKLQDHLRQLSILFRKLR.LVYD
  104-  134 (39.91/23.27)	GGMDPiPVEKLKQKNQQLKQIMDQLRnLIWD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26122 with Med30 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA