<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26121

Description "Cell division cycle 2-like 6 (CDK8-like) (Predicted), isoform CRA_c"
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPVAPQQQAAAPTQAPPPQQSSAQTNGTAGGATTGGGAAGAGLQHSQDSGLNQVPPNKKPRIGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQGTLGYSSSQQSTQYHPSHQAHRY
Length501
PositionKinase
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.09
Grand average of hydropathy-0.683
Instability index53.16
Isoelectric point8.66
Molecular weight56612.43
Publications
PubMed=15057822
PubMed=15632090

Function

Annotated function 
GO - Cellular Component
cytosol	GO:0005829	IDA:RGD
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IDA:RGD

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
cell division	GO:0051301	IEA:UniProtKB-KW
cellular response to lipopolysaccharide	GO:0071222	IERGD
positive regulation of apoptotic process	GO:0043065	IMRGD
positive regulation of inflammatory response	GO:0050729	IMRGD
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26121
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.73|      16|      17|     319|     334|       1
---------------------------------------------------------------------------
  319-  334 (27.37/15.48)	DPTKRITSEQALQDPY
  338-  353 (29.36/17.14)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.27|      35|      37|     411|     445|       2
---------------------------------------------------------------------------
  388-  426 (50.97/28.14)	QAAAPTQAPPPQQSSAqtnGtAGGATTGGGAAGAGLQHS
  427-  461 (66.31/38.82)	QDSGLNQVPPNKKPRI...G.PSGANSGGPVMPSDYQHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      41|     151|     165|       3
---------------------------------------------------------------------------
  151-  165 (26.77/20.17)	DLKPANILVMGEGPE
  189-  203 (28.67/22.15)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26121 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQPQQQNPHQQPVAPQQQAAAPTQAPPPQQSSAQTNGTAGGATTGGGAAGAGLQHSQDSGLNQVPPNKKPRIGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQGTLGYSSSQQSTQYHPSHQAHRY
353
501










Molecular Recognition Features






MoRF SequenceStartStop




1) LNYQS
2) TLGYSSSQ
3) TQYHPSHQAHRY
4) VPPNKKPRIGP
465
480
490
434
469
487
501
444