<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26120

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGVCGSAIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVNSHSSHVISAQSTSSLPTTPAPQPPTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGTPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKDVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFVFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDSEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKAKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGTAPPSTEERKKKSTKGKKRSQPATKSEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQSSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQPQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2187
PositionKinase
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.07
Grand average of hydropathy-0.518
Instability index58.22
Isoelectric point6.73
Molecular weight244222.93
Publications
PubMed=15057822
PubMed=22673903

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	ISO:RGD
nucleus	GO:0005634	ISO:RGD
ubiquitin ligase complex	GO:0000151	IDA:RGD

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	ISO:RGD
protein C-terminus binding	GO:0008022	ISO:RGD
protein domain specific binding	GO:0019904	ISO:RGD
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	ISO:RGD
thyroid hormone receptor binding	GO:0046966	ISO:RGD
transcription coactivator activity	GO:0003713	ISO:RGD
transcription coregulator activity	GO:0003712	ISO:RGD
transcription factor binding	GO:0008134	ISO:RGD

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	ISO:RGD
canonical Wnt signaling pathway	GO:0060070	ISO:RGD
embryonic brain development	GO:1990403	ISO:RGD
embryonic neurocranium morphogenesis	GO:0048702	ISO:RGD
embryonic organ development	GO:0048568	ISO:RGD
endoderm development	GO:0007492	ISO:RGD
heart development	GO:0007507	ISO:RGD
neural tube closure	GO:0001843	ISO:RGD
neural tube development	GO:0021915	ISO:RGD
oligodendrocyte development	GO:0014003	ISO:RGD
positive regulation of transcription by RNA polymerase II	GO:0045944	ISO:RGD
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:RGD
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
post-anal tail morphogenesis	GO:0036342	ISO:RGD
protein ubiquitination	GO:0016567	IDA:RGD
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
Schwann cell development	GO:0014044	ISO:RGD
somitogenesis	GO:0001756	ISO:RGD
spinal cord development	GO:0021510	ISO:RGD
stem cell population maintenance	GO:0019827	ISO:RGD
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26120
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     158.31|      15|      15|    2053|    2067|       1
---------------------------------------------------------------------------
 2053- 2066 (30.02/10.17)	.....QQQQQQQ..QQQQQQQ
 2067- 2083 (32.13/11.41)	Q..qqQQQQQQQ..QQQQQQQ
 2084- 2104 (25.79/ 7.71)	QyhirQQQQQQQilRQQQQQQ
 2105- 2119 (36.93/14.20)	Q....QQQQQQQ..QQQQQQQ
 2120- 2134 (33.44/12.16)	Q....QPQQQQP..HQQQQQA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     273.71|      79|     345|     602|     705|       2
---------------------------------------------------------------------------
  614-  705 (125.67/82.04)	MYTCTLISRGDLAFGTPGPRPPSpfddpADDPERKEAEGSSSSKledPGL.SESMDIDPSSSVLFEDMEKPDFSLFSPTmpcegKGSPSPEKP
 1727- 1771 (85.51/34.21)	LYHTHLRPRPRAYYLEPLPLPP...........................................EDEEPPAPALLEPE.....KKAPEPPKT
 1774- 1822 (62.53/22.63)	................PGTAPPS.....TEERKKKSTKGKKRSQ...PATkSEDYGMGPGRSGPYGVTVPPDL....................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     519.00|     168|     233|     169|     374|       3
---------------------------------------------------------------------------
  169-  349 (267.74/184.65)	AMSETKVKKKNTAdpFTEWTQI....ITKYLWEQLQKMAEYYRPGPAGSGVCGSAIGPLPHDVEM....AIRQWDYNEKLalfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLAlQLDGVNSHSShvISAQSTSSlPTTPAPQ...............PPTSNTPSTPFSD
  401-  596 (251.25/172.39)	APSNLPMPEGNSA..FTQQVRAklreIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERCG.ESEAADEKGS..VASGSLSA.PSAPIFQdvllqfldtqapmltDPRSESERVEFFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     301.62|     109|     200|    1065|    1264|       4
---------------------------------------------------------------------------
  739-  819 (106.67/40.79)	FPIPQEESCSHECNQRLVvlfGVGKQRDdaRHAI....KKITKD....ILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRN......................................................................................................................................................................................................................................................................................................
 1074- 1106 (27.17/114.46)	.........................................................................................rpeafptaedifakfqhlshydqhqvtaqvsrnvleqitsfalgmsyhlplvqhvqfvfdlmeyslsisglidfaiqllnelsvveaelllkssdlvgsyttslclcivavlrhyhaclilnqdqmaqvfeglcgvvkhgmnrsdgssaercilaylydlytscshlkskfgelfsdfcskvkntiycnvepsesnmrwapefmidtlenpaahtftytglgkslsenpanrysfvcnalmhvcvghhdpdrvnDIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNN
 1181- 1307 (167.78/98.38)	FKTPQLNPCQSDGNKPTV...GIRSSCD..RHLLaasqNRIVDGavfaVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQ...........................................................................................................................................................................................................................................................ggrNISVETASLDVYAKYVlrsicQQEWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.88|      15|      15|     854|     868|       5
---------------------------------------------------------------------------
  854-  868 (26.85/19.96)	LEQITSFALG.MSYHL
  870-  885 (23.03/15.91)	LVQHVQFVFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     211.60|      34|     227|    1908|    1941|       6
---------------------------------------------------------------------------
 1852- 1891 (42.92/20.32)	A................GG....PRVdpyrpvRLPMQKLPTRPTYPGVLPTTMT.TVMGLE
 1892- 1941 (51.02/25.83)	PssyktsvyrqqqptvpQG....QRL......RQQLQQSQGMLGQSSVHQMTPS.SSYGLQ
 1946- 1976 (42.58/20.10)	Y................TS....YVS......HVGLQQHTGPAGT....MVPPSySSQPYQ
 1984- 2007 (33.15/13.69)	P................TL....VDP......TRHLQQRPS..GY..VHQQAPT.......
 2009- 2041 (41.92/19.64)	G................HGltstQRF......SHQTLQQTPMMG.....TMTPL.SAQGVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.36|      70|     162|    1421|    1501|       9
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 1421- 1501 (101.00/89.98)	LERSGVWLVAPLIAKLPTSVQGHVlkaagEElEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSL......VLTClkgqdEQREGLL
 1584- 1659 (109.36/70.41)	LDMLSVLINGTLAADMSSISQGSM.....EE.NKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLpkqnrdVITC.....EPQGSLI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26120 with Med12 domain of Kingdom Metazoa
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