<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26109

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNHQQQSQSQSQQSPTIESTSQQQQQQPPQQQQTIKLSTVIHRLVQDSYNNLIGLTEISPSLKDVDKKRTLLDYFDQTRERFLRLLVILKWSSHIDTLTKANDIIQLLEKEDSFFREAADMLILTKENLINARAPIYDIPTAVDVMTSGTYQRMPVNIGMVLPPPILSNTEISRAIDKLNNIICYKLFLSDVPSEFEPIRVENGRAYLTVKNEYEAFLTIDGASEGKGPIKIRVDERVKEVTERIQNRLAHSKQPLHELHNIIHSLVVSAQLDSLSSQMDALKKTAFRSNIKCVQGKDLSLTIFFWISEEIANSVGSLDVKKHMNIKIYIDDSNKLHVSYTPNIQNARSDSSLRIPSLNIETILMRAMELHAHFRVQHLYNILFEDYLNKLKLQQHQQQQQQQLQLTSGTTNTNTPSSSGSSSSCKSFQINDFKMIFSSQHQQKQQSSNETSNIVTSTDDSLPTILRVQLYGSNYLDITVNQLTGKFNILLSSSKNHEIKSIVNTFKLRSLLSCFEEAALFMRLECFYKIPLVSQLFTEQNYICIRFPKYKDIYYLVISIHPTTFLPIFHLIYSKPSLNSAIFTVTPDTPAAAAATTAKPTTPTDTTTSTTTFTIGIAAATATATAAAATTAAVTAVTATATGASTTAAIETVSTGYLPFGETSVRDRQVSDQHCQCRAATDWLSSFKSDLIAINKIINLASQLVKQLRISKEFQSTFQILSIKPKEIEFICLNYSLSKSTIKIVVNKQNQIVLDYQPFVNPLLPFFEKDLNESMNMENLLHSIAISNEIVFSIQAIIYTPNSSTSQFLPLEIYVIPRSSTQIRLIYKNVYGIDIRFVSTENCIVEDAHYTNVMANLYPQVHRSKLMAIPYIHLIMEHRINVVALDNQGFRSSWLVPMRQFRASLQRIVLFMSCTFLFNILRSAIKVEFNDIMHQALTMKFSSETIQFHLNVRDYSTFELDASNKPEDQWRLVSPANHCKRSQHADGAASGVARIAQDSAWRPGASAPTPLHRRHLSVGSVVASRPRAIHPQARCTRRVHDTPILQSHKPACARSLRVNLYRYTDQLVVPSIHKTR
Length1076
PositionTail
OrganismPolysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500) (Heterostelium pallidum)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Acytosteliales> Acytosteliaceae> Heterostelium.
Aromaticity0.08
Grand average of hydropathy-0.210
Instability index52.03
Isoelectric point9.00
Molecular weight121723.82
Publications
PubMed=21757610

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26109
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.09|      15|      15|     619|     633|       1
---------------------------------------------------------------------------
  602-  616 (22.79/12.64)	TPTDTTTSTTTFTIG
  619-  633 (25.65/15.10)	AATATATAAAATTAA
  636-  649 (23.65/13.39)	AVTATATG.ASTTAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      96.95|      15|      15|       4|      18|       2
---------------------------------------------------------------------------
    4-   18 (27.52/14.03)	QQQSQSQSQQ....SPTIE
   22-   36 (29.19/15.31)	QQQQQQPPQQ....QQTIK
  394-  412 (22.52/10.18)	QQHQQQQQQQlqltSGTTN
  441-  454 (17.71/ 6.48)	HQQKQQSSNE....TSNI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.01|      10|     589|     466|     477|       5
---------------------------------------------------------------------------
  466-  477 (15.00/14.95)	LRVQLYgsNYLD
 1056- 1065 (20.01/11.59)	LRVNLY..RYTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.80|      12|      15|     100|     112|       6
---------------------------------------------------------------------------
  100-  112 (15.07/15.09)	KANDIIqLLEKED
  117-  128 (19.74/13.44)	EAADML.ILTKEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.46|      12|     381|     185|     199|       8
---------------------------------------------------------------------------
  185-  197 (16.58/19.09)	YKLFLSdVPSEFE
  204-  215 (20.88/ 8.10)	GRAYLT.VKNEYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.02|      15|     381|     137|     155|       9
---------------------------------------------------------------------------
  137-  151 (27.99/12.63)	YDIPTAVDVMTSGTY
  528-  542 (27.03/ 9.49)	YKIPLVSQLFTEQNY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26109 with Med14 domain of Kingdom Amoebozoa
Unable to open file!