<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26106
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MNSNNNNAIGNISTPNSNGSNTPSPHQQQQQQQQQQMMMQQQQQQMDMGMGMLQQMDESQRTVRLSTVIHRLVEQSYNRLIELSVNLVNQSDLDKKKQLSDYFEETRERFVRLLVIIKWSKHLNTLNKANEIMELLNQQDIYLRDTADLLIMTKEGMINSRAPQRQTETEQHHCVQAVSERYTKGVSTADCHRQWHCTYSGGRRVRGDTHPGGCRRVDAMDHSRPPNLRAETARNRSTTHQSGDYFVIKSKLELLTSQTYNTFTRNQLLQQQQLQQQQQQQQQQNQQQQQQLIQSSTNSNIRAIYGRDASITIFYWIPDDIIMTASSNLDPNIHTNIKIYLHDESELIVNHTPIIKHPTTENYLRIFKLNVEEILLRAINLHSFHRANILFQHLIDSNQEYQQFAELIRNVALDGSDSSDGGNGNNAKYNGNDSARNNNSSSCNGKQNKDDTNINVNNETLPTVLKVNLYGSNELIVSINSHNGKYIISPNHLLSNDLQIQMEYRLNKNYQEITNIVNQLKLKSLLSCFEESSLFLKLECFYKIPLTLDLFADNNYICIRLPKDRDIYYLIITVNITTFQPSFHLATIKSNSQSSIMQHSSTSKIESNSLNQFISMLDDYVMLKKDNNKNKDNLKMIKKNKNKQIKADNNDNKEVGKDGHFQYHRYLLELLTRVVNTTKKRISVRSAIEVLTSHDQTFKHDTNLDIITFFHSTPNPFIQVADQTMTLSLAKDNNTCTITFNESNLHQHYQFTPPIITNPTNPPHYHFEDGQWSFTYNTSIDWLKEFKNDLFIINKTIQLSVVINHFFNSIAKPEITNYLQIQAFKPMEIELSCSKTSASRSTIKIFIDRTHRKYSIDYQPHPNPFLSLLERQLNEIPIANTITSTTYNHLTNLNHITSINNSIEQLFKSIVITNDIIYSIHSIITSDTPQYFLPLEIMIIPRSTTQLRLVYKNTYGIDIRAISAEHCSVEDAFYSMQAVGSISISKHFQSVLKPELPTMSFKFETESVIYQIAVRDFSTFELDTFSSKCGDARAPAALYLFATSIVGHVDRLRGTEIPTSSSSSSSSSSSIPTTTLTSSNSTTSTTNKQ |
Length | 1089 |
Position | Tail |
Organism | Polysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500) (Heterostelium pallidum) |
Kingdom | Amoebozoa |
Lineage | Eukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Acytosteliales>
Acytosteliaceae> Heterostelium.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.565 |
Instability index | 44.08 |
Isoelectric point | 7.45 |
Molecular weight | 125027.12 |
Publications | PubMed=21757610
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26106
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 89.42| 19| 20| 191| 209| 1
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171- 186 (20.03/10.13) ...QHHCVQAVSERYTKGV
191- 209 (38.01/25.53) CHRQWHCTYSGGRRVRGDT
214- 232 (31.37/19.84) CRRVDAMDHSRPPNLRAET
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 469.76| 117| 246| 14| 166| 2
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14- 144 (181.58/105.55) TPNSNGSNTPSPHQQ.QQQQ...................................QQQQMMMQQQQQQMdmgmgMLQQMDESQrtVRlsTVihrlvEQSYNR........LIELSVNLVNQSDLDK..KKQLSDYFEETRERFVRLLVIIKWSKHLNTLNKANEI.MELLNQQDI.YLR
259- 377 (163.60/71.21) TYNTFTRNQLLQQQQlQQQQ...................................QQQQQQNQQQQQQ......LIQSSTNSN..IR..AI........YGRdasitifyWIPDDIIMTASSNLDPniHTNIKIYLHDESELIVNHTPIIKHPTTENYLR....I.FK.LNVEEI.LLR
435- 570 (124.59/66.46) ARNNNSSSCNGKQNK.DDTNinvnnetlptvlkvnlygsnelivsinshngkyiiSPNHLLSNDLQIQM...........................EYRLNK........NYQEITNIVNQLKL.....KSLLSCFEES.SLFLKLECFYKIPLTLDLFADNNYIcIRLPKDRDIyYL.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.70| 13| 15| 738| 751| 3
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738- 751 (21.90/16.09) ITFNESNlHQHYQF
755- 767 (27.80/16.07) IITNPTN.PPHYHF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 166.47| 46| 207| 661| 718| 4
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669- 718 (77.58/72.90) ELLTRVVNttkkRISVRSAIEVLT...............SHDQTFKH...DTNLDIITFFHS.....TPNPFI
840- 865 (34.26/14.07) ................RSTIKIFI.................DRTHRK....YSID....YQP.....HPNPF.
867- 933 (54.63/27.80) SLLERQLN....EIPIANTITSTTynhltnlnhitsinnSIEQLFK.sivITN.DIIYSIHSiitsdTPQYFL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.71| 26| 175| 800| 830| 5
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800- 830 (36.65/34.95) SVVINHFFNSIAKPEitnyLQIQAFKpMEIE
981- 1006 (47.06/27.55) SISISKHFQSVLKPE....LPTMSFK.FETE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 126.96| 34| 229| 396| 429| 6
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396- 429 (56.24/30.19) DSNQEYQQFAELIRN.VALDGSDSSDGGNGNNAKY
606- 638 (38.76/18.76) ESNS.LNQFISMLDDyVMLKKDNNKNKDNLKMIK.
640- 663 (31.96/14.32) ..NKNKQ.....IKA....DNNDNKEVGKDGHFQY
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