<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26106

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNSNNNNAIGNISTPNSNGSNTPSPHQQQQQQQQQQMMMQQQQQQMDMGMGMLQQMDESQRTVRLSTVIHRLVEQSYNRLIELSVNLVNQSDLDKKKQLSDYFEETRERFVRLLVIIKWSKHLNTLNKANEIMELLNQQDIYLRDTADLLIMTKEGMINSRAPQRQTETEQHHCVQAVSERYTKGVSTADCHRQWHCTYSGGRRVRGDTHPGGCRRVDAMDHSRPPNLRAETARNRSTTHQSGDYFVIKSKLELLTSQTYNTFTRNQLLQQQQLQQQQQQQQQQNQQQQQQLIQSSTNSNIRAIYGRDASITIFYWIPDDIIMTASSNLDPNIHTNIKIYLHDESELIVNHTPIIKHPTTENYLRIFKLNVEEILLRAINLHSFHRANILFQHLIDSNQEYQQFAELIRNVALDGSDSSDGGNGNNAKYNGNDSARNNNSSSCNGKQNKDDTNINVNNETLPTVLKVNLYGSNELIVSINSHNGKYIISPNHLLSNDLQIQMEYRLNKNYQEITNIVNQLKLKSLLSCFEESSLFLKLECFYKIPLTLDLFADNNYICIRLPKDRDIYYLIITVNITTFQPSFHLATIKSNSQSSIMQHSSTSKIESNSLNQFISMLDDYVMLKKDNNKNKDNLKMIKKNKNKQIKADNNDNKEVGKDGHFQYHRYLLELLTRVVNTTKKRISVRSAIEVLTSHDQTFKHDTNLDIITFFHSTPNPFIQVADQTMTLSLAKDNNTCTITFNESNLHQHYQFTPPIITNPTNPPHYHFEDGQWSFTYNTSIDWLKEFKNDLFIINKTIQLSVVINHFFNSIAKPEITNYLQIQAFKPMEIELSCSKTSASRSTIKIFIDRTHRKYSIDYQPHPNPFLSLLERQLNEIPIANTITSTTYNHLTNLNHITSINNSIEQLFKSIVITNDIIYSIHSIITSDTPQYFLPLEIMIIPRSTTQLRLVYKNTYGIDIRAISAEHCSVEDAFYSMQAVGSISISKHFQSVLKPELPTMSFKFETESVIYQIAVRDFSTFELDTFSSKCGDARAPAALYLFATSIVGHVDRLRGTEIPTSSSSSSSSSSSIPTTTLTSSNSTTSTTNKQ
Length1089
PositionTail
OrganismPolysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500) (Heterostelium pallidum)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Acytosteliales> Acytosteliaceae> Heterostelium.
Aromaticity0.08
Grand average of hydropathy-0.565
Instability index44.08
Isoelectric point7.45
Molecular weight125027.12
Publications
PubMed=21757610

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26106
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.42|      19|      20|     191|     209|       1
---------------------------------------------------------------------------
  171-  186 (20.03/10.13)	...QHHCVQAVSERYTKGV
  191-  209 (38.01/25.53)	CHRQWHCTYSGGRRVRGDT
  214-  232 (31.37/19.84)	CRRVDAMDHSRPPNLRAET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     469.76|     117|     246|      14|     166|       2
---------------------------------------------------------------------------
   14-  144 (181.58/105.55)	TPNSNGSNTPSPHQQ.QQQQ...................................QQQQMMMQQQQQQMdmgmgMLQQMDESQrtVRlsTVihrlvEQSYNR........LIELSVNLVNQSDLDK..KKQLSDYFEETRERFVRLLVIIKWSKHLNTLNKANEI.MELLNQQDI.YLR
  259-  377 (163.60/71.21)	TYNTFTRNQLLQQQQlQQQQ...................................QQQQQQNQQQQQQ......LIQSSTNSN..IR..AI........YGRdasitifyWIPDDIIMTASSNLDPniHTNIKIYLHDESELIVNHTPIIKHPTTENYLR....I.FK.LNVEEI.LLR
  435-  570 (124.59/66.46)	ARNNNSSSCNGKQNK.DDTNinvnnetlptvlkvnlygsnelivsinshngkyiiSPNHLLSNDLQIQM...........................EYRLNK........NYQEITNIVNQLKL.....KSLLSCFEES.SLFLKLECFYKIPLTLDLFADNNYIcIRLPKDRDIyYL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.70|      13|      15|     738|     751|       3
---------------------------------------------------------------------------
  738-  751 (21.90/16.09)	ITFNESNlHQHYQF
  755-  767 (27.80/16.07)	IITNPTN.PPHYHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     166.47|      46|     207|     661|     718|       4
---------------------------------------------------------------------------
  669-  718 (77.58/72.90)	ELLTRVVNttkkRISVRSAIEVLT...............SHDQTFKH...DTNLDIITFFHS.....TPNPFI
  840-  865 (34.26/14.07)	................RSTIKIFI.................DRTHRK....YSID....YQP.....HPNPF.
  867-  933 (54.63/27.80)	SLLERQLN....EIPIANTITSTTynhltnlnhitsinnSIEQLFK.sivITN.DIIYSIHSiitsdTPQYFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.71|      26|     175|     800|     830|       5
---------------------------------------------------------------------------
  800-  830 (36.65/34.95)	SVVINHFFNSIAKPEitnyLQIQAFKpMEIE
  981- 1006 (47.06/27.55)	SISISKHFQSVLKPE....LPTMSFK.FETE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.96|      34|     229|     396|     429|       6
---------------------------------------------------------------------------
  396-  429 (56.24/30.19)	DSNQEYQQFAELIRN.VALDGSDSSDGGNGNNAKY
  606-  638 (38.76/18.76)	ESNS.LNQFISMLDDyVMLKKDNNKNKDNLKMIK.
  640-  663 (31.96/14.32)	..NKNKQ.....IKA....DNNDNKEVGKDGHFQY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26106 with Med14 domain of Kingdom Amoebozoa
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