<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26103

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMAQNENITISAFPPPPPFYKLYLNYQAPSSTSSTPPHPSVAAQNAKNDDAKFSVPAPPTRSPSSLSVSPQLNSAQATTTSPTTTTTTTTTSSSSIQLQPLLPPLPPKKGSTFQMFGQHYSTTDVLPSLTEMGVEQLYPNGDIDPIKELKRLNRSIVFNYLQLLETLVENPSEYKTKVDDISLLFVNFHHLLNSYRPHQARETLISIMTEQIKQKRESITKINNTINSCKEILKKTLQTVNTEEIAKLKQHVKQLQEIQYIGSTTEQSIIQSPSTTPLLAQTSPITTTTTTTTTTTTNATIISSSTSTTTTTTTSNNNNNNDQWINDYLQKLSLISKN
Length337
PositionMiddle
OrganismPolysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500) (Heterostelium pallidum)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Acytosteliales> Acytosteliaceae> Heterostelium.
Aromaticity0.06
Grand average of hydropathy-0.538
Instability index58.24
Isoelectric point8.46
Molecular weight37222.32
Publications
PubMed=21757610

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26103
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.21|      13|      16|     284|     296|       1
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   78-   89 (20.22/ 6.35)	.TTSPTTTTTTTT
  284-  296 (25.83/10.07)	ITTTTTTTTTTTT
  301-  313 (24.17/ 8.97)	ISSSTSTTTTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.96|      17|      19|      10|      26|       2
---------------------------------------------------------------------------
   17-   38 (26.92/14.55)	PFYKLYLNYQapsstSST..PPHP
   39-   58 (19.04/ 8.13)	SVAAQNAKND....dAKFsvPAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.07|      16|      23|     216|     231|       3
---------------------------------------------------------------------------
  216-  231 (26.64/18.08)	ESITKINNTINSCKEI
  242-  257 (25.43/16.95)	EEIAKLKQHVKQLQEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.10|      11|      32|      61|      71|       4
---------------------------------------------------------------------------
   61-   71 (19.36/ 9.21)	SPSSLSVSPQL
   91-  101 (18.74/ 8.72)	SSSSIQLQPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.35|      23|      35|     134|     167|       5
---------------------------------------------------------------------------
  134-  167 (26.09/46.49)	EqlYpNGDIDPIkelkrlnrSIVF.NYLQLL.........ETLV
  172-  204 (30.26/19.20)	E..Y.KTKVDDI........SLLFvNFHHLLnsyrphqarETLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26103 with Med7 domain of Kingdom Amoebozoa
Unable to open file!