<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26100

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDNSNDQFEREASTRKQILFQHFQETRERFIRLLVLLRWSKKSKKTLDKFNQVSSAMDLKVNSFDMASFTLFHAARILSRLREPVFDLPTAIDVLTTGTYPRLPHIIQQSRGDLQNSADDFTTQDKERAISKLTDIIRMKLLQCTIPPNMFVNKLENGQVNLIAENEFSIIMTLNHKREEGESNTDELKYYWQIIYLDLLVNEDGINVSPIHDDIVQRLSTVIQKRLYYLDESDTMVPSMVDIYNIIHLVTIRIAMDIITKQAKTLKWPNEIVTCETFNESVDQDFSLSLKYWHKAPPMVSFIEKVMDGIEDDEKNFFLKDKGSRNELKIFIDKSKQIVFDMQPKLRCNYTPAINLSRINLGKIISDCIFYHSIERLESVKVFLNRERLFPDIQLITDAESNQAYLSISVFEEYILILGIDWKTGHFQLHLSVDGEKLDVDYSEFVTRINNIDVRKSKFSEQLLSSLEGARKRTIIHAYKTAGALLDLDVHSALFEGDGLSDENVYFSFPNVSTAFIQIRVTPFSYERRKPLVSSRVVIERSPKIIDIPIPSSLFLDIYQPAPEEEIDSYEPTQKRVKRMTCMTALQKTLVAFRHLKQIIAASKHKVLFGTMLRQVQISNRFSYDLTDQEYEMIILPNDNSNFSFLDLECITLSIDVNTYEWVATVYERRPLPVIIPQNSKQHYVNDRLTFKYTTMRNCQNLFEEFYQDLLSIDRMYPLALQVIHPSPHFAGILQQACTVEMVSHTKIRIDYGNCGYKLIIKNVDKRYRVILYPTNRFEADLEEYFNKHSRNDTYGEVMCKLVQLLLKSTVPLNKLKQFLSDRHPTSWYLIPRSMYSFKVVHKGKTTREFLVTCRASGQVEFKATDDSFHVISAPFGEEIDNAVLSLKRCCTSSTLLENMSPPLQIALSAENIKQQDNTLSFSSPTYEYSCEFNNYELKLTKIVPRKNSILTKDEEEFLKEAFTKYYLNSALEAGVSLSGNFFSHSFLLILFFPNPLFKHVVQAWYLLKDKIDLVFFNPYPVRNAQRRTYDESFGLAEVKLPTSLSALLPVFSSGKIIEKKTLNSVYVITLLVRVYIGDDFIDLPIQYGANMELKFGDQKLTSEVATKIIGESQRQEVPEEGSDNTLLKLLTYITANCTIPQLLDI
Length1146
PositionTail
OrganismNaegleria gruberi (Amoeba)
KingdomHeterolobosea
LineageEukaryota> Discoba> Heterolobosea> Tetramitia> Eutetramitia> Vahlkampfiidae> Naegleria.
Aromaticity0.10
Grand average of hydropathy-0.234
Instability index38.83
Isoelectric point6.18
Molecular weight132704.88
Publications
PubMed=20211133

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26100
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.50|      87|     153|     485|     631|       1
---------------------------------------------------------------------------
  492-  631 (96.40/190.24)	SalfegdgLS.DENVYfsfPNVSTAfiqirvtpfsYERRkPLvssRVVIERSPK...........IIDIPIPSSLFLDIYQPApeEEIDsyeptqkrvkRMTCMtALqktlvafrhlkQIIAASKHkvlFGTMLRQV....QIS...............................NRFSYDLtdQEY
  652-  785 (129.10/83.71)	T.......LSiDVNTY...EWVATV..........YERR.PL...PVIIPQNSKqhyvndrltfkYTTMRNCQNLFEEFYQDL..LSID..........RMYPL.AL...........QVIHPSPH...FAGILQQActveMVShtkiridygncgykliiknvdkryrvilyptNRFEADL..EEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.80|      65|     634|     203|     279|       2
---------------------------------------------------------------------------
  203-  279 (91.71/114.85)	EDGINV..SPIHDDIVQRLSTViqKRLYyldESDTMVPSMVDIyniihlVTIRIAMDIITKQAKTLKW..PNEIVTCEtFN
  866-  934 (105.09/86.90)	DDSFHVisAPFGEEIDNAVLSL..KRCC...TSSTLLENMSPP......LQIALSAENIKQQDNTLSFssPTYEYSCE.FN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26100 with Med14 domain of Kingdom Heterolobosea
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